Protein Alignment Oatp58Db and SLCO4C1

DIOPT Version :10

• Sequence 1: NP_611658.3
• Gene: Oatp58Db / 37544
• FlyBaseID: FBgn0034715
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_851322.3
• Gene: SLCO4C1 / 353189
• HGNCID: 23612
• Length: 724
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 174/651 - (26%)
• Similarity: 311/651 - (47%)
• Gaps: 68/651 - (10%)

  Fly    20 NVADDEKRLNS----SDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFTYFTG-----T 75
            ||::::.|..|    .:.:.|:..|....|||..|...|::.|    |.||:.......     :
Human    69 NVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHY----CLLAVTQGIVVNGLVNIS 129

  Fly    76 ITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHI 140
            |:|:|||:.:.:.::|||:...|||....|.|:|::..|||:|||:|....:|.:..|:...|..
Human   130 ISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQF 194

  Fly   141 FYGPGEEALRLTEEYGMSESFGASLNITEKNDSLCHEKNSNCLERAGDYTPIVLFFIAQFIGGIG 205
            |.|          ||.:...|..:. :|.:|.:.|....|:    ..:|  :.:|.:.|.:.|.|
Human   195 FSG----------EYKLGSLFEDTC-VTTRNSTSCTSSTSS----LSNY--LYVFILGQLLLGAG 242

  Fly   206 CSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYIDPF--KKPLITTND 268
            .:..|..|.:::||:..:.|:...:.....:.:||||:|:.:....|.:|||..  :...:|.:|
Human   243 GTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDD 307

  Fly   269 PRWMGAWWIGWILLTFILTISAVF-VGMFPKEMPRA-------KARRLKADGEEDIPLAGRSFQD 325
            |||:||||||: ||::|...|.:. ...|||.:|..       .::..:::...|:.. |:|.:|
Human   308 PRWLGAWWIGF-LLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKF-GKSIKD 370

  Fly   326 MLDSLKRLASNKVYVYNMLAS---ILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFS 387
            ...:||.|..|.|::..:|::   .|...|:.   .|.||:||.|:..::|.:....|...:..:
Human   371 FPAALKNLMKNAVFMCLVLSTSSEALITTGFA---TFLPKFIENQFGLTSSFAATLGGAVLIPGA 432

  Fly   388 AAGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRAN-SLSIVPTGD---- 447
            |.|.::.|:::||::.:.:....:......:.:.....::...|:....|. |.|...||:
Human   433 ALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNL 497

  Fly   448 --SCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRCMGNVSSIISLSNV 510
              .|:|:|.|...||.|||. :.:.:.|.|.|||::...:...| :|..|.|:...:.|.|.:..
Human   498 IAPCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPK-VYYNCSCIERKTEITSTAET 560

  Fly   511 TSLASQSQIAMDGACPVDCNKQ--FLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGF 573
            ....:::     |.|...|.|.  ||....::....|:..|..:.::   ||||..:.::.:||.
Human   561 FGFEAKA-----GKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSI---LRCVNHRQRSLALGI 617

  Fly   574 GSMVYSVLAFIPSPIVFGWMLDSYCLVWG-KTCSSKGNCWIYDTKSLRYTMNLVCASLIFLGSFW 637
            ..||..:|..||.||:||:.:||.|::|. ..|..||.|||||...:.:.:..:..:...:..|:
Human   618 QFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFF 682

  Fly   638 N 638
            |
Human   683 N 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:460821	162/593 (27%)
SLCO4C1	NP_851322.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..71		1/1 (100%)
		MFS_SLCO4C_OATP4C	104..604	CDD:341021	135/535 (25%)