DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and slco1d1

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001335015.1	Gene:	slco1d1 / 326845	ZFINID:	ZDB-GENE-030131-5044	Length:	689	Species:	Danio rerio

Alignment Length:	709	Identity:	196/709 - (27%)
Similarity:	320/709 - (45%)	Gaps:	110/709 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LQRFATAHMFVIVYGIASCFLAMAF--TYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAF 107
            |:.|..|..||        |.|.||  :|...::|.:|:||::|:.:.|.|....:|..:|..||
Zfish    14 LKMFLAAMCFV--------FFAKAFQGSYMKSSVTQIERRFDVPSSLIGFIDGSFEIGNLFVIAF 70

  Fly   108 LSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEEYGMSES---FGASLNITE 169
            :||:.::.||||.:|.|.::::....:...||.|.|          :|....:   |.||:|.||
Zfish    71 VSYFGAKLHRPRLIAAGCLVMSAGSFITAMPHFFQG----------QYKYESTISHFSASVNGTE 125

  Fly   170 K------NDSLCH-------EKNSNCLERAGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDNS 221
            .      |.||..       |..:.| |:|...:..:..|:...:.|||.:.....||||:||.|
Zfish   126 NVLPCLTNASLAQDSEIPTVESQAEC-EKASSSSLWLFVFLGNMLRGIGETPVMPLGLSYLDDFS 189

  Fly   222 ASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYIDPFKKPL--ITTN--DPRWMGAWWIGWILL 282
            ....|...|:....:.::||..||.:.|.|.:||:|.....|  ||.|  |.||:||||:|:::.
Zfish   190 REENTAFYLALIQTVGIMGPMFGFMLGSFCAKLYVDIGTVDLDSITINYKDSRWVGAWWLGFLVT 254

  Fly   283 TFILTISAVFVGMFPKEMPR---------------AKARRLKADGEEDIPLAGRS--------FQ 324
            ..::.::.:.....||.:.|               .:..|...|..:..|.|.:.        .:
Zfish   255 GGVMLLAGIPFWFLPKSLTRQGEPESEKKPGAPEGGEQERFIPDNNKHNPPASKPAPVTMSALAK 319

  Fly   325 DMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSAA 389
            |.|.|||:|.||.:||..:...::.:.|::....|.||::|..|.||||.:....|...|...|.
Zfish   320 DFLPSLKKLFSNTIYVLLVCTGLIQVSGFIGMITFKPKFMEQVYGQSASRAIFLIGIMNLPAVAL 384

  Fly   390 GILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRANSLSIVPTG-------- 446
            ||:..|:::.::|.:....|....|...|....||....:.||.|..| .|::...|
Zfish   385 GIVTGGFIMKRFKVNVLGAAKICIVASVLAFCSMLIQYFLQCDNSQVA-GLTVTYQGAPEVSYQT 448

  Fly   447 ----DSCSASCVCEYVYYAPVCSPENITFISACHAGC-TDKAINELGKTIYTGCRCMGNVSSIIS 506
                ..|:..|.|...::.|:|:...:|:.|.|.||| |...|.:  :.::..|.|:|  .:::.
Zfish   449 ETLISQCNIGCSCSLKHWDPICASNGVTYTSPCLAGCQTSTGIGK--EMVFHNCSCIG--EALLP 509

  Fly   507 LSNVTSLASQSQIAMDGACP--VDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTF 569
            .:|::        |:.|.||  .||:..|.|::||.....|..|.|.:...::.||.:..:.|:.
Zfish   510 YTNMS--------AVLGQCPRKSDCDFMFKIYMAVTVIGAFFSAVGATPGYIILLRSITPELKSL 566

  Fly   570 SLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWG-KTCSSKGNCWIYDTKSLRYT-MNLVCASLIF 632
            :||..:::...|..||.||.||.::|..||.|| |.|..:|.|.|||:.:.|.. :.|:.|  ::
Zfish   567 ALGMHTLIVRTLGGIPPPIYFGALIDKTCLKWGLKQCGGRGACRIYDSGAFRNAFLGLIYA--LY 629

  Fly   633 LGSFWNIGVWYH----------AKD-MKVFDEDE---KTVQAKQSDDIELKEKPNDVVT 677
            ..|:...|:.|:          .|| :|..::|.   .|.....|..|...|.|:...|
Zfish   630 SSSYLLFGLLYNRLSHREKKQALKDQLKAPEQDSCGVSTTNGNASSAIVKCENPDQETT 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	177/626 (28%)
		MFS	55..>410	CDD:119392	111/399 (28%)
		KAZAL_SLC21	447..499	CDD:238650	15/52 (29%)
slco1d1	NP_001335015.1	OATP	16..617	CDD:308646	179/632 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920