DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and Slco6c1

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_775460.1	Gene:	Slco6c1 / 287006	RGDID:	708431	Length:	701	Species:	Rattus norvegicus

Alignment Length:	713	Identity:	157/713 - (22%)
Similarity:	265/713 - (37%)	Gaps:	151/713 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DEKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCF-------LAMAFTYFTGTITTMEK 81
            |.|...|.:...|......|.||||.....|:|.: |||..       ||........::.|:.|
  Rat    59 DPKYSASKEGPFGLGPLVFPCLQRFNNIDCFMIFF-IASVLIHGALFALADMILNLYHSLLTLSK 122

  Fly    82 RFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGE 146
            |.......||.|     :|::. :.|::::..:|:|.:|:|...|::|...:|:..|.
  Rat   123 RELYFMDFSGYI-----VSSLV-AIFVAHFGGKGNRTKWIAAACILMAFGSILLGFPF------- 174

  Fly   147 EALRLTEEYGMSESFGASLNI-TEKNDSLCHEKNSNCLERAG-DYTPIVLFF-IAQFIGGIGCSL 208
                  .:|.:.:|.|..:.: .|:|    ..:|.:|:..:. |.|..:.|| |.|.:.||....
  Rat   175 ------SKYEIMKSGGQRVELCVEEN----KRRNIHCVTNSNPDRTKCICFFIIGQCLNGIAGMP 229

  Fly   209 FYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGF--SMVSLCLRLYIDPFKKPLITTNDPR- 270
            .|..|.:::.|:..:......|:......::|..:|.  .|.:|.     .|.|:.|...:..:
  Rat   230 IYILGKTFILDHVPTRSAGFYLALGHSAHLMGYFLGIFGGMKNLS-----PPPKEKLSAVDSAKI 289

  Fly   271 ---WMGAWWIGWILLTFILTIS-AVFVGM--FPKEMPRAKARRLKADGEEDIPLAGRSFQDMLDS 329
               ....||..::   |:..|| :||:.:  ||..:|          |...:.||.|......|
  Rat   290 HLLLQFGWWKTFL---FVAAISFSVFLVLLCFPTSLP----------GAHKLKLAKRKEPPTFD- 340

  Fly   330 LKRLASNKVY---------VYNMLASILYL----------FGYMPYWIFTPKYIEIQYRQSASTS 375
             |||...|:.         ::.||.:.|.:          |.:.....|.|.:::.|:..:...:
  Rat   341 -KRLKDQKIQPRFKGFVFAIWYMLRNPLLMTQAMCKVSESFAFHTSLEFLPYHLQTQFSITPQIA 404

  Fly   376 TMATGTWALGFSAAGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLVGC--------- 431
            :|.||.:.:.....|..:.|.::.:.:.:.:....::.|...::||..|....|.|
  Rat   405 SMLTGLFVIPGGVIGHFLGGLIVDRLEMTNKNKLKFSLVTSVVSVALFLLIFFVECETTKFAGIN 469

  Fly   432 DESDRANSLSIVPTGDSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCR 496
            ::.|....|..:..|  |:..|.|....|:.||..:...:.|.|.|||:...:.:..||.| .|.
  Rat   470 EDYDGLGKLGNLTAG--CNYHCACTTSLYSSVCGRDEKEYFSPCFAGCSATKVQQNEKTYY-NCS 531

  Fly   497 CMGNVSSIISLSNVTSLASQSQI-AMDGACPVDCNKQFLIF--------LAVMCFLKFVGATGRS 552
            |       |.....||.|....| |.||.|..:|....|.|        .:.||....:
  Rat   532 C-------IKEGLTTSDADGHFIDATDGTCNSNCLTLPLFFAFYFSATVFSTMCSTPII------ 583

  Fly   553 SNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWG-KTCSSKGNCWIYDT 616
               |:.|:.||:...:...|....:....|.:|.|.:||......|..|. ..|..:..||||:.
  Rat   584 ---LIILQSVPANFSSLGQGVTVAITKFTASVPEPALFGTASSVACKFWDINACGVREKCWIYNK 645

  Fly   617 KSLRYTMNLVCASLIFLGSFWNIGVWYHAK---------DMKVFD-------EDEKTVQAKQS 663
            .:|.|..               ||:|...|         .:.::|       .|.||...|.|
  Rat   646 TTLVYVF---------------IGIWVSFKLFTALLNIYAIHIYDYVVKGKISDSKTTHVKAS 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	136/622 (22%)
		MFS	55..>410	CDD:119392	79/392 (20%)
		KAZAL_SLC21	447..499	CDD:238650	16/51 (31%)
Slco6c1	NP_775460.1	OATP	88..648	CDD:281175	136/622 (22%)
		MFS	90..>457	CDD:119392	83/410 (20%)
		KAZAL_SLC21	481..534	CDD:238650	17/62 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910