DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and F21G4.1

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_509659.3	Gene:	F21G4.1 / 181203	WormBaseID:	WBGene00009023	Length:	640	Species:	Caenorhabditis elegans

Alignment Length:	675	Identity:	169/675 - (25%)
Similarity:	297/675 - (44%)	Gaps:	109/675 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 MFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHR 117
            :.|:|..:...:|.    |..|.:||:||||...::.||.:....||....:...:.|..|..|.
Worm    22 LMVLVIAVQGTYLG----YVVGMLTTLEKRFGFSSEKSGWLLSLYDIGHTMAILLIGYIGSHYHL 82

  Fly   118 PRWVALGLIIIAIFCLLMLTPHIFYGPG----EEALRLTEEYG--MSESFGASLNITEKNDSLC- 175
            ||...:|:|:.::...::..|.:|||..    |:.::..|.|.  ||........|:.:.:. |
Worm    83 PRITGIGVILSSLSMFMLALPVLFYGTADYTQEQLMQKKEAYSVEMSCDTNGRREISSQGED-CW 146

  Fly   176 --HEKNSNCLERAGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDN-SASSKTPAMLSWSSFLR 237
              |.:::|..        |:|.| .|...||..:.|......|:|.| ....::|.:|...:.:.
Worm   147 REHHEHTNAF--------IILAF-GQLFAGIFAAPFNTIAYVYIDSNVKQKRESPFLLGLLTSMY 202

  Fly   238 MLGPAMGFSMVSLCLRLYIDPFKKP-LITTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEMP 301
            ..|||:||.:.|:...:|......| .|.|:|..|:||||:|:::......|.||....||:...
Worm   203 AFGPALGFMLSSILNGVYTSLGDAPDHIGTHDEHWIGAWWLGFLVCGSAYLILAVPFFFFPRTYK 267

  Fly   302 RAKARRLKADG-------------EEDIPLAGRSFQDMLDSLKRLASNKVYVYNMLASIL--YLF 351
            ...:..|..:.             :|:|.|..|.|..:   ||:|.:||||:..::|.:.  ||.
Worm   268 HPDSFHLMLEHSRPQVSPEDRLTFKENITLFLREFPMV---LKKLITNKVYITMVIAWMFGSYLI 329

  Fly   352 GYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARA-----MAAW 411
            |  .|..:.||:||.||.:|||.:.:.:|..::|..|....:.|:::|:|..:.|:     :.:|
Worm   330 G--GYQTYLPKFIETQYGRSASMADIYSGIISVGAIAVSTALGGWILSRYNIAPRSSIICLIGSW 392

  Fly   412 NFVVDYLTVAGMLCYVL---VGCDESDRANSLSIVPTG------------DSCSASCVCEYVYYA 461
                    :..::.|::   :||.: .:...|:.|...            ..|...|.||.|...
Worm   393 --------IVILVSYIIGMNLGCSQ-PKVEGLTYVDYASRWHFYHHREREQECLEYCNCETVLKF 448

  Fly   462 PVCSPENITFISACHAGCTDKAINELGKTIYTGCRC-MGNVSSIISLSNVTSLASQSQIAMDGAC 525
            ...|.....|.|.||||||:   .::....::.|:| .||:..                  .|..
Worm   449 DGVSYNGQNFYSPCHAGCTE---YDIYSNTWSNCQCAYGNMVD------------------KGLV 492

  Fly   526 PVDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVF 590
            ..||. .|..:||||....|:|.......:::.||.|..::|..:|...|.:.::..|||:|:::
Worm   493 HPDCG-IFFAYLAVMLIGLFIGNLFFMVTMMIVLRSVFDEEKVIALSLASFITNLFGFIPAPVIY 556

  Fly   591 GWMLDSYCLVWGKTC-SSKGNCWIYDTKSLRYTMNLVCA-----SLIFLGSFWNIGVWYHAKDMK 649
            |:.:|..|::|.:.| :.:|||.:||........:.|.:     ::||.|    |..|. :|.:|
Worm   557 GFFIDLCCILWNRQCPNERGNCVLYDNDMFTKMFHGVNSFFQVFAIIFAG----ICYWL-SKTVK 616

  Fly   650 VFDEDEKTVQAKQSDDIELKEKPND 674
            : .|:...|...:|.:.|.:::..:
Worm   617 L-PEEMPMVDFPESREREYRDEEEE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	157/613 (26%)
		MFS	55..>410	CDD:119392	103/385 (27%)
		KAZAL_SLC21	447..499	CDD:238650	16/52 (31%)
F21G4.1	NP_509659.3	OATP	18..586	CDD:281175	157/613 (26%)
		MFS	20..>402	CDD:119392	105/406 (26%)
		KAZAL_SLC21	433..481	CDD:238650	15/50 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28658
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930