DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Db and Y32F6B.1

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_505689.2	Gene:	Y32F6B.1 / 179463	WormBaseID:	WBGene00012531	Length:	760	Species:	Caenorhabditis elegans

Alignment Length:	774	Identity:	189/774 - (24%)
Similarity:	310/774 - (40%)	Gaps:	188/774 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHRP 118
            |.||:|......::...|.|..:..:||:|.||:::||.:....|.:.:....|.||:..:|:|.
Worm     9 FFIVFGTVYFLESIGGFYMTSAVVFIEKQFQIPSRLSGTMVSAGDFAYIPVVIFTSYFGGKGNRA 73

  Fly   119 RWVALGLIIIAIFCLLM-------------LTPHI------------------------------ 140
            ||:..|.|:|||...::             :|.||
Worm    74 RWIGAGCILIAIANFMIASSNFLFPVEQANVTTHIPSALAHQIDRDIVNGDVNSTEHLWLEQIHP 138

  Fly   141 ----------------------------FYGPGEEALRLTEEYGMSESFGASLNITEKNDS---- 173
                                        .|..|.|..:..|:| ::|.|    .||:...|
Worm   139 LIDPKNQVVMNYEGDEKSDLLQKYVEYCHYHKGSEICKNLEKY-IAEKF----PITDAKMSNVRA 198

  Fly   174 -------LCHE-------KNSNCLERAGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASS 224
                   .||.       ::..|.:......|.::.|....:.|:|.::.::.||..||||....
Worm   199 MVALPYGFCHSMLNFVRAQHYACKKDQSTLGPFMMIFGGLLVLGVGRTMPFSLGLPLMDDNVKKQ 263

  Fly   225 KTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYIDPFKKPL-ITTNDPRWMGAWWIGWILLTFILTI 288
            ..|...|:..|:::|||.:|..:.....:||:| |..|. :|..||.|:|.||:|:::...:|..
Worm   264 NLPLYFSFMFFVKILGPVIGLLVGGQLNKLYVD-FNPPQGLTPLDPMWIGCWWLGFLIFGTLLFG 327

  Fly   289 SAVFVGMFP----------------KEMPRAKA----RRLKADGEEDIPLAGRSFQDMLDSLK-- 331
            .::.:..||                |..||.:.    |.:|.| |:...|...:..|.::..|
Worm   328 PSLVLYFFPSDDLDINAPEEFDDDGKVKPRKRLNLVDRHIKKD-EQGNALMPETIMDKINDFKAT 391

  Fly   332 --RLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQY--------RQSASTSTMATGTWALGF 386
              .|..||::|..|...|:.:..:..|::|..||:|:|:        |..|||.       .:||
Worm   392 IANLVKNKIFVGAMFGRIIDVLAFKGYFVFQAKYLELQFGVPQYRIQRYIASTG-------IVGF 449

  Fly   387 SAAGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYV--LVGCDESDRANSLSIV------ 443
             |.|:::....:...|...|..|||..|..  .||.::.:.  .|||.        |::
Worm   450 -ACGVILGSLSMKFLKLQGRKAAAWVAVCS--LVAALISFANGTVGCK--------SVIGQIGDQ 503

  Fly   444 -----PTGDSCSASCVCEYVYYAPVCSPENITFISACHAGCT---------DKAINELGKTIYTG 494
                 |..|.|...|:||.....|||......:.|.|||||.         |.....:...|:..
Worm   504 IKINGPVFDGCRDDCMCEQTPLYPVCDVSGSAYYSPCHAGCAMGWKNYSIFDNTKATVDTLIFEN 568

  Fly   495 CRCMGNVSSIISLSNVTSLASQSQIAMDGACPVDCNKQFLIFLAVMCFLKFVGATGRSSNLLLAL 559
            |.|:.|....:|.|...:              .:|.::|..|.....|....|..|....:|:.|
Worm   569 CACVDNKVKEVSRSYCRT--------------EECEERFGRFFMHQAFGAVFGGLGVVPGMLIVL 619

  Fly   560 RCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGKTCSSKGNCWIYDTKSLRYTMN 624
            |.||.:.::.||||...:.|:||.:||||::|.::|..||:|.|:|.|.|:|.:|||..||..::
Worm   620 RAVPPEHRSVSLGFNGFLVSLLATLPSPIIWGKIIDMSCLLWKKSCDSSGSCSVYDTDELRVRLH 684

  Fly   625 LVCASLIFLGSFWNIGVWYHAKDMKVFDEDEKTVQAKQSDDIE-----LKEKPNDVVTK 678
            ::...|.......::.|||.|:.:|:.:|:....:.|:.::.|     .||...|...|
Worm   685 VIYGCLRIFSLISDVWVWYWARGLKLIEEETPEDKDKKEEETEKLHSKRKESLRDAAEK 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	174/708 (25%)
		MFS	55..>410	CDD:119392	106/476 (22%)
		KAZAL_SLC21	447..499	CDD:238650	18/60 (30%)
Y32F6B.1	NP_505689.2	oat	4..706	CDD:273279	180/735 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28658
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760