DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and Slco1a4

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_571981.1	Gene:	Slco1a4 / 170698	RGDID:	621389	Length:	661	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	188/716 - (26%)
Similarity:	304/716 - (42%)	Gaps:	123/716 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKI 89
            |||:.:....|            ||...||::....|....:::.||....:|.:|::|.|||.|
  Rat     5 EKRVATHGVRC------------FAKIKMFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSI 57

  Fly    90 SGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEE 154
            .|||....:|..:....|:||:.::.|||..:.:|..::.:.|.|:..||...|        ..|
  Rat    58 VGLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISLPHFLMG--------QYE 114

  Fly   155 YGMSESFGASLNITEKNDSLCHEKNSNCLERAGDYTPIV-----LFFIAQFIG----GIGCSLFY 210
            |   |:...:.|:: .|...|.|..|..|....|.:..|     |.:|...:|    |||.:...
  Rat   115 Y---ETILPTSNVS-SNSFFCVENRSQTLNPTQDPSECVKEMKSLMWIYVLVGNIIRGIGETPIM 175

  Fly   211 APGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYID----PFKKPLITTNDPRW 271
            ..|:||::|.:.|..:|..:........:||.:|..:.|.|..:|:|    ......||..|.||
  Rat   176 PLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLASSCANIYVDIESVNTDDLTITPTDTRW 240

  Fly   272 MGAWWIGWILLTFILTISAVFVGMFPKEMP--------------RAKARRLKADGEEDIPLAGRS 322
            :||||||:::...:..:::.....|||.:|              :.|..|.||..|:      |.
  Rat   241 VGAWWIGFLVCAGVNILTSFPFFFFPKTLPKEGLQENVDGTENAKEKKHRKKAKEEK------RG 299

  Fly   323 F-QDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGF 386
            . :|....:|.|:.|.:|:..:|.|:|....::..:.|.|||:|.||.:|.:......|.:.|..
  Rat   300 ITKDFFVFMKSLSCNPIYMLFILISVLQFNAFINSFTFMPKYLEQQYGKSTAEVVFLMGLYMLPP 364

  Fly   387 SAAGILISGYVISKYK---PSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRANSLSIVPTG-- 446
            ...|.||.|.::.|:|   ..|..:|.|..:.:||  ...|.||:. ||....| .|:....|
  Rat   365 ICLGYLIGGLIMKKFKVTVKKAAHLAFWLCLSEYL--LSFLSYVMT-CDNFPVA-GLTTSYEGVQ 425

  Fly   447 ----------DSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRCM--- 498
                      ..|:..|.|....:.|||....:.::|||.||| :|::......::..|.|:
  Rat   426 HQLYVENKVLADCNTRCNCSTNTWDPVCGDNGLAYMSACLAGC-EKSVGTGTNMVFQNCSCIQSS 489

  Fly   499 GNVSSIISLSNVTSLASQSQIAMDGACPVDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVP 563
            ||.|:::.|.|...               ||..:...||.:..|..|:.:.......::.|||:.
  Rat   490 GNSSAVLGLCNKGP---------------DCANKLQYFLIIAIFGCFIYSLAGIPGYMVLLRCIK 539

  Fly   564 SKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGK-TCSSKGNCWIYDTKSLRYTMNLVC 627
            |::|:..:|..:....:||.||:||.||.::|..||.||. .|...|.|.:||..|.|
  Rat   540 SEEKSLGVGLHAFCIRILAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFR------- 597

  Fly   628 ASLIFLG--------SFWNIGVWYHAKDMKVFD-----EDEKTVQAKQSDDIELKEKPNDVVTKK 679
              .::||        ||  :..::..:..:.|.     |..||..|:..  :.|||.....|.:.
  Rat   598 --RLYLGLPAALRGASF--VPAFFILRLTRTFQFPGDIESSKTDHAEMK--LTLKESECTEVLRS 656

  Fly   680 K 680
            |
  Rat   657 K 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	166/612 (27%)
		MFS	55..>410	CDD:119392	102/385 (26%)
		KAZAL_SLC21	447..499	CDD:238650	15/54 (28%)
Slco1a4	NP_571981.1	oat	1..623	CDD:273279	178/678 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920