Protein Alignment Oatp58Db and Slco1a4

DIOPT Version :10

• Sequence 1: NP_611658.3
• Gene: Oatp58Db / 37544
• FlyBaseID: FBgn0034715
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_571981.1
• Gene: Slco1a4 / 170698
• RGDID: 621389
• Length: 661
• Species: Rattus norvegicus
• Alignment Length: 716
• Identity: 188/716 - (26%)
• Similarity: 304/716 - (42%)
• Gaps: 123/716 - (17%)

  Fly    25 EKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKI 89
            |||:.:....|            ||...||::....|....:::.||....:|.:|::|.|||.|
  Rat     5 EKRVATHGVRC------------FAKIKMFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSI 57

  Fly    90 SGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEE 154
            .|||....:|..:....|:||:.::.|||..:.:|..::.:.|.|:..||...|        ..|
  Rat    58 VGLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISLPHFLMG--------QYE 114

  Fly   155 YGMSESFGASLNITEKNDSLCHEKNSNCLERAGDYTPIV-----LFFIAQFIG----GIGCSLFY 210
            |   |:...:.|:: .|...|.|..|..|....|.:..|     |.:|...:|    |||.:...
  Rat   115 Y---ETILPTSNVS-SNSFFCVENRSQTLNPTQDPSECVKEMKSLMWIYVLVGNIIRGIGETPIM 175

  Fly   211 APGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYID----PFKKPLITTNDPRW 271
            ..|:||::|.:.|..:|..:........:||.:|..:.|.|..:|:|    ......||..|.||
  Rat   176 PLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLASSCANIYVDIESVNTDDLTITPTDTRW 240

  Fly   272 MGAWWIGWILLTFILTISAVFVGMFPKEMP--------------RAKARRLKADGEEDIPLAGRS 322
            :||||||:::...:..:::.....|||.:|              :.|..|.||..|:      |.
  Rat   241 VGAWWIGFLVCAGVNILTSFPFFFFPKTLPKEGLQENVDGTENAKEKKHRKKAKEEK------RG 299

  Fly   323 F-QDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGF 386
            . :|....:|.|:.|.:|:..:|.|:|....::..:.|.|||:|.||.:|.:......|.:.|..
  Rat   300 ITKDFFVFMKSLSCNPIYMLFILISVLQFNAFINSFTFMPKYLEQQYGKSTAEVVFLMGLYMLPP 364

  Fly   387 SAAGILISGYVISKYK---PSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRANSLSIVPTG-- 446
            ...|.||.|.::.|:|   ..|..:|.|..:.:||  ...|.||:. ||....| .|:....|
  Rat   365 ICLGYLIGGLIMKKFKVTVKKAAHLAFWLCLSEYL--LSFLSYVMT-CDNFPVA-GLTTSYEGVQ 425

  Fly   447 ----------DSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRCM--- 498
                      ..|:..|.|....:.|||....:.::|||.||| :|::......::..|.|:
  Rat   426 HQLYVENKVLADCNTRCNCSTNTWDPVCGDNGLAYMSACLAGC-EKSVGTGTNMVFQNCSCIQSS 489

  Fly   499 GNVSSIISLSNVTSLASQSQIAMDGACPVDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVP 563
            ||.|:::.|.|...               ||..:...||.:..|..|:.:.......::.|||:.
  Rat   490 GNSSAVLGLCNKGP---------------DCANKLQYFLIIAIFGCFIYSLAGIPGYMVLLRCIK 539

  Fly   564 SKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGK-TCSSKGNCWIYDTKSLRYTMNLVC 627
            |::|:..:|..:....:||.||:||.||.::|..||.||. .|...|.|.:||..|.|
  Rat   540 SEEKSLGVGLHAFCIRILAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFR------- 597

  Fly   628 ASLIFLG--------SFWNIGVWYHAKDMKVFD-----EDEKTVQAKQSDDIELKEKPNDVVTKK 679
              .::||        ||  :..::..:..:.|.     |..||..|:..  :.|||.....|.:.
  Rat   598 --RLYLGLPAALRGASF--VPAFFILRLTRTFQFPGDIESSKTDHAEMK--LTLKESECTEVLRS 656

  Fly   680 K 680
            |
  Rat   657 K 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:460821	166/612 (27%)
Slco1a4	NP_571981.1	oat	1..623	CDD:273279	178/678 (26%)