DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and slco1e1

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_009299376.1	Gene:	slco1e1 / 100332946	ZFINID:	ZDB-GENE-100818-2	Length:	695	Species:	Danio rerio

Alignment Length:	717	Identity:	186/717 - (25%)
Similarity:	307/717 - (42%)	Gaps:	94/717 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DDEKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPT 87
            :|..:..|....|.   ...|...|.::..:|:.....|.....:..||....||.:|:||::.:
Zfish     7 EDNGKPTSQQELCS---PEAPEEPRCSSLKIFIGALSFAYFSKTLCGTYMKSAITQIERRFDLSS 68

  Fly    88 KISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLT 152
            ...||:....::..:...|.:|::.:|.||||.:.:|..::||...|...||:|.|
Zfish    69 SAVGLVDGSFEMGNLLFVAVVSHFGARLHRPRLIGMGCFLMAIGSALTGLPHVFMG--------- 124

  Fly   153 EEYGMSESFGASLNIT-----------EKNDSLCHEKN---SNCLERAGDYTPIVLFFIAQFIGG 203
             .|....:.....|.|           ....|:.|..|   ::|::..|. :..:..|:...:.|
Zfish   125 -RYKFDTAIQGFANETVVIAPCQYPTNPSEHSIQHIDNTTGTDCVKDPGS-SMWIYVFLGNALRG 187

  Fly   204 IGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYID----PFKKPLI 264
            ||.:.....|:||:||.:.:..:...:|....:.:|||..||.:.|:|.:||:|    ......|
Zfish   188 IGETPVTPLGISYIDDFAKAENSAFYISCLQTIMLLGPMFGFLLGSMCAKLYVDIGFVSVDSVSI 252

  Fly   265 TTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEMPRAKARRLKADGEEDIPLAGRS------- 322
            |..|.||:||||:|:.:.:..|.:|.|.....|:.:|:        .|||:..:....
Zfish   253 TPQDARWVGAWWLGFFVSSAFLVLSGVPFWFLPRSLPK--------QGEEEKEICNTDDANKEHS 309

  Fly   323 -------------FQDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSAST 374
                         .:..|.|||||.....|...:...:|....::....|..||:|.|:.||||.
Zfish   310 VLQTTHTMTLADIAKGFLPSLKRLLCTPAYFLLLCGIVLKFNSFIGLLTFKAKYMEQQFGQSASR 374

  Fly   375 STMATGTWALGFSAAGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRA-- 437
            :....|...|...|.||.:.|.::.:||.|..|.|..:|:..:.....:|.:....||....|
Zfish   375 ANFLIGVLILPVVAVGIFLGGLLMKRYKLSVVAGAQLSFITSFTAFLLLLLHFGTKCDNVPVAGL 439

  Fly   438 ----NSLSIVPTG-----DSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGK-TIY 492
                |....:|:.     ..|:..|.|....:.||||...||::|.|.||||  |....|| |::
Zfish   440 TVSYNGTPYMPSDQRSLESQCNQDCSCSTSEWDPVCSDSGITYMSPCLAGCT--ASTGQGKNTVF 502

  Fly   493 TGCRCMGNVSSIISLSNVTSLASQSQIAMDGACPVD--CNKQFLIFLAVMCFLKFVGATGRSSNL 555
            ..|.|      ::|.|......|.|.    |.||..  |.:.|..::||.....|:.:.|.:...
Zfish   503 HNCSC------VLSPSPAEGGRSVSL----GQCPQGSACARSFTSYMAVSVLSSFINSLGTTPGY 557

  Fly   556 LLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWG-KTCSSKGNCWIYDTKSL 619
            ::.:||:..:.|:.:||..::|...|..||:||.||.::||.||.|| |.|..:|.|.|||:...
Zfish   558 MIIIRCIAPELKSLALGIQTLVMRTLGGIPAPIYFGALIDSACLKWGLKKCGGRGACRIYDSNMY 622

  Fly   620 RYTMNLVCASLIFLGSFWNIGVWYHAKDMKVFDEDEKTVQ--AKQSDDIELK----EKPNDVVTK 678
            |.....:..:|.....|:.|.|....: .:...|:.|.:|  |.:.::|||:    :.|:...|.
Zfish   623 RVIFLSLTTALSGCSYFFIIAVIVLLR-RQFIKEEVKALQQMAGKQNEIELRSPEMQNPDGTKTD 686

  Fly   679 KK 680
            ::
Zfish   687 ER 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	167/618 (27%)
		MFS	55..>410	CDD:119392	98/392 (25%)
		KAZAL_SLC21	447..499	CDD:238650	21/52 (40%)
slco1e1	XP_009299376.1	OATP	34..622	CDD:281175	167/618 (27%)
		MFS	36..>288	CDD:119392	67/262 (26%)
		KAZAL_SLC21	456..508	CDD:238650	21/59 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920