DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Db and slco1f2

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001121745.2	Gene:	slco1f2 / 100190901	ZFINID:	ZDB-GENE-080305-3	Length:	662	Species:	Danio rerio

Alignment Length:	713	Identity:	191/713 - (26%)
Similarity:	323/713 - (45%)	Gaps:	122/713 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 INVADDEKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFT--YFTGTITTMEK 81
            |.:...::...:|.|.|     ..|.|:.|..|        :|.|:.:.:.|  |...|||.:|:
Zfish     6 IGMEHSDRNQKTSQTKC-----CPPRLKIFIAA--------LAFCYFSKSMTASYTKSTITQIER 57

  Fly    82 RFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGE 146
            ||.||:...|:|..|.::..:.....:||..::.|||:.:..|::::.|..|||.:||...|
Zfish    58 RFEIPSSTVGIIDGGFEMGNMLVITLVSYVGAKFHRPKIIGAGVLLMGIGTLLMASPHFIMG--- 119

  Fly   147 EALRLTEEYGMSESFGASLNITEKND-------SLCHEKN--------SNCLERAGDYTPI-VLF 195
                 ..:||.:        .|..||       |.|...:        |.|.:...:.:|: |:.
Zfish   120 -----RYKYGTA--------ATHTNDAGNFTVISTCSSDSQKTLQQPFSGCRKEEAESSPLWVIV 171

  Fly   196 FIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYID--- 257
            .:...:.|||.:.....|:|::||.:....:...:...:.::.:||..||.:.|||..||:|
Zfish   172 VLGNTMLGIGEASIIPLGMSFVDDYARPENSAFYIGCLNTIKGIGPIFGFVLGSLCANLYVDIGL 236

  Fly   258 -PFKKPLITTNDPRWMGAWWIGWILLTFILTISAVFVGMF-PKEMPRAKARRL---KADGEEDIP 317
             ..:...||..|.||:||||:|:: ::.:||:.|.|...| ||.:|......|   .....:..|
Zfish   237 VNKESVTITPQDSRWVGAWWLGYV-VSGLLTVLAAFPFWFLPKALPENSQISLLDNTPQQHKTTP 300

  Fly   318 LAGRSFQDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTW 382
            ......:|...:.|||.:||:|:..:..||:....:.....:||||:|.|:.||||.:....|..
Zfish   301 SLTEIVKDFAPTFKRLLTNKIYILYLAYSIVAFNDFAILVTYTPKYLEQQFGQSASKANFLIGVT 365

  Fly   383 ALGFSAAGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRANSLSIVP--- 444
            .:...|.|:.:||.::.::|....|.|..|.:....||...:.:..:.|:..|.|.  ..||
Zfish   366 CVPAVALGVFLSGLMMKRFKWGLLASARVNLLTIVATVFLTVPFFALSCENLDIAG--VTVPYQG 428

  Fly   445 -------TGD---SCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRC-- 497
                   |.|   ||:|.|.|..:::.|||....:|:||.|||||:........||.: .|.|
Zfish   429 STEVQGVTSDVLPSCNADCGCPDLHWDPVCGENGVTYISPCHAGCSSTQGAGRNKTFH-DCGCIQ 492

  Fly   498 -----MGNVSSIISLSNVTSLASQSQIAMDGACP--VDCNKQFLIFLAVMCFLKFVGATGRSSNL 555
                 :||.|:::                 |.|.  .:||:...::|.:.....||.:.|.....
Zfish   493 SWGLSVGNSSAVL-----------------GQCSQNPNCNRMMYLYLGLQSLALFVYSLGAVPLF 540

  Fly   556 LLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWG--KTCSSKGNCWIYDTKS 618
            .::||.|..:.|:.|:|...:...||..||:||.||.::||.||.||  |:| .:|.|.|||.::
Zfish   541 TMSLRIVDPELKSLSVGVLLLSIRVLGGIPAPIYFGALVDSSCLKWGQRKSC-GRGACRIYDIET 604

  Fly   619 LRY-------TMNLVCASLIFLGSFWNIGVWYHAKDMKVFDEDEKTVQAKQSDDIELKEKPND 674
            .|:       .:.::..||:::.:.|          :|...:::|.:    |:|:||:..|:|
Zfish   605 FRFLFQGLTNCLRVLACSLLWIATIW----------IKRKIQNDKQI----SEDMELQRGPSD 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	171/615 (28%)
		MFS	55..>410	CDD:119392	102/380 (27%)
		KAZAL_SLC21	447..499	CDD:238650	21/61 (34%)
slco1f2	NP_001121745.2	OATP	29..605	CDD:281175	173/621 (28%)
		MFS	31..>413	CDD:119392	107/406 (26%)
		KAZAL_SLC21	440..492	CDD:238650	20/52 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D434101at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920