DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and Slco1a6

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_570092.1	Gene:	Slco1a6 / 84608	RGDID:	69304	Length:	670	Species:	Rattus norvegicus

Alignment Length:	667	Identity:	181/667 - (27%)
Similarity:	297/667 - (44%)	Gaps:	64/667 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 FATEHMYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYA 126
            ||...::::....|.....::..|.|..:|.:|:|:.|.|.:.|:|:...::..:|....:.|:.
  Rat    16 FAKIKVFLLALTWAYASKALSATYMNSMLTQIERRFNISTSIVGLINGSFEVGNLLLIIFVSYFG 80

  Fly   127 GHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQLTREFGQVNETLTNQERDKKLCQPT-- 189
            ..||||..:|||...:...|.:.|..|||.|..|....::......:.:....|...:..:||
  Rat    81 RKRHRPIMIGIGCAVMGLGCFIISLPHFLMGRYEYETTISPTSNLSSNSFLCMENRTQTLKPTQD 145

  Fly   190 AGGCVQEEVGL-WVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGP 253
            ...||:|...| |   :::....:|.|:|:.....|||:|::|......:|..:.:....::.||
  Rat   146 PAECVKEMKSLMW---IYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPFYIGILEVGKITGP 207

  Fly   254 AIGYSLAAVCLRLYIE----PTLEPLIGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPS 314
            .....|.:.|..:|::    .|.:..|...|.|.:||||:|:||.|.:.::.:|..|.|||..|.
  Rat   208 IAAIWLGSFCATIYVDMGSVNTDDLTITPTDTRCVGAWWIGFLVCAGLNILISIPFFFFPKTFPK 272

  Fly   315 ARKRRL--QLKQDE---RKQSLPLNERSLA-DMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWI 373
            .....:  :.|.||   .::.....:|.:. |....:|.||.|.:|:...:.|:|...|::..:.
  Rat   273 EGPEDMANETKNDEGDKHREKAKEEKRGITKDFFLFMKSLSCNPIYMLCVLTSVLQVNGFVSIFT 337

  Fly   374 FTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGI 438
            |.|||:|..|.:|::.|....|...|.....|.||||:::.|:|.:.:..|..:..:........
  Rat   338 FKPKYLEHHYGKSSSEAIFLMGLYTLPSVCVGYLISGFIMKKFKITLKKAAFISYCLGMSECLLS 402

  Fly   439 LCYVAIGCEGSDRLNTLTTLSAG------------NSCSASCHCDYVHYAPVCSADNITFISACH 491
            ||...:.|:... :..|||...|            ..|:..|.|....:.|||..:.:.:|:.|.
  Rat   403 LCNFMLTCDNVP-IAGLTTSYEGIQQSFDMENTVLADCNTRCSCLTKTWDPVCGDNGLAYITPCL 466

  Fly   492 AGCSERTKDALGRTIYTGCECLGSSSLNSEPESQFAVDGTC---PVDCFNEFLIFLGVMCFLKLV 553
            |||.:.....: ..:...|.|:.||..:|      ||.|.|   | ||.|:...||.:..|....
  Rat   467 AGCEKSVGSGI-NMVLQDCSCIQSSGNSS------AVLGLCNKGP-DCANKLQYFLIITVFCSFF 523

  Fly   554 GASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWG-KTCSNKGN 617
            .:.|.....::.||||..:||:..:||.:....:||.|.:||:||.|||..||.|| :.|...|.
  Rat   524 YSLSLIPGYMIFLRCMKSEEKSLGIGLQAFCMRILGGILAPIYFGVLIDRTCLHWGTQKCGEPGA 588

  Fly   618 CWLYDTKSMR-YALNLSA---------AFFIF-------LGGFLNIAVWYHAKNLKIFDEEESSP 665
            |..|:..|.| ..|.|.|         ||||.       ..|.:|..|..|.:  .:..|:||..
  Rat   589 CRTYEINSFRSIYLGLPAALRGSSYLPAFFILRLMRKFQFPGDINSPVTDHVE--MMLTEKESEH 651

  Fly   666 KDSLKNKEV----EMKT 678
            .|..::.:|    |:||
  Rat   652 TDVHRSPQVENDGELKT 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	158/587 (27%)
		MFS	69..>425	CDD:119392	96/368 (26%)
		KAZAL_SLC21	462..514	CDD:238650	13/51 (25%)
Slco1a6	NP_570092.1	oat	1..625	CDD:273279	169/620 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..295		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..670		7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820