DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and Slco1c1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_445893.1	Gene:	Slco1c1 / 84511	RGDID:	628660	Length:	716	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	190/678 - (28%)
Similarity:	305/678 - (44%)	Gaps:	125/678 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 MTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAF 145
            :|..|...|||.:|:|:.||:.:.|||....:|..:|....:.|:....|||:.:|.|.|.:...
  Rat    58 LTEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFG 122

  Fly   146 CLLTSSLHFL--------YGAGEDALQLT---------------REFGQVNETLTNQERDKKLCQ 187
            .:|.:...|.        |.....:..||               |.....::...|.|     |:
  Rat   123 TMLIAVPQFFMEKYSYEKYERYSPSSNLTPNISPCYLESSSPSPRSIVGKSQNKINDE-----CE 182

  Fly   188 PTAGGCVQEEVGLWVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLG 252
                  |.....:|   |::|...|:.|:|:.....|||||:||..|:......:.....:.::|
  Rat   183 ------VDTSSSMW---VYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIG 238

  Fly   253 PAIGYSLAAVCLRLYIE--------PTLEPLIGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFP 309
            |..|:.|.::|.:||::        .|:.|    :||:|:||||||:|:...::|::|:..:..|
  Rat   239 PIFGFLLGSLCAKLYVDIGFVNLDHITITP----KDPQWVGAWWLGYLIAGFLSLLAAVPFWCLP 299

  Fly   310 KQLPSARKRRLQLKQDERKQSL---PLN------ERSL------ADMMKTVKKLSKNKVYVYNTM 359
            |.||.::.|.......|:.:.:   |:|      |.|:      .|.:.::|.|.:|.||:....
  Rat   300 KTLPRSQSREDSGSSSEKSKFITDDPVNYQMAPREESMKIMEMARDFLPSLKSLFRNPVYILYLC 364

  Fly   360 ASILYF---FGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSAR 421
            ||.:.|   ||.:.|   .|||||.||.||::.|....|.:.:...|.||...|.|:.|::
  Rat   365 ASTVQFNSLFGMVTY---KPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFR---- 422

  Fly   422 AMAAWNAIVDFV--TVAGILCYV---AIGCEGSDRLNTLTTLSAG------------NSCSASCH 469
             :....|...::  :|.|.|.::   |:|||.|. :..||....|            :.|::.|.
  Rat   423 -LGICEATKLYLGSSVFGYLLFLSLFALGCENSS-VAGLTVSYQGTKPVSYHERALFSDCNSRCK 485

  Fly   470 CDYVHYAPVCSADNITFISACHAGCSERTKDALGRT-IYTGCECLGSSSLNSEPESQFAVDGTCP 533
            |....:.|:|..:.||:.|||.|||...::.  |:. |::.|.|:|.::..|...|  .:.|.|.
  Rat   486 CSDSKWEPMCGDNGITYASACLAGCQSSSRS--GKNIIFSNCTCVGFAAPKSGNWS--GMMGRCQ 546

  Fly   534 VD--CFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSPIF 596
            .|  |...||.||.:........:.......:|.|||:.|..|:||||:.::|..:|..||:|::
  Rat   547 KDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVY 611

  Fly   597 FGWLIDNYCLVWG-KTCSNKGNCWLYDTKSMRYALNLSAAFFIFLG---------GFLNIAVW-- 649
            ||.|||..||.|| |.|.::|:|.|||:.:.|:         |:||         .||:.||.
  Rat   612 FGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRH---------IYLGLTTLLGTVSVFLSTAVLLV 667

  Fly   650 ----YHAKNLKIFDEEESSPKDSLKNKE 673
                |.:|........|.....|...||
  Rat   668 LKKKYVSKRSSFITAREKIVMSSSVKKE 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	176/614 (29%)
		MFS	69..>425	CDD:119392	105/392 (27%)
		KAZAL_SLC21	462..514	CDD:238650	17/52 (33%)
Slco1c1	NP_445893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		OATP	44..642	CDD:281175	176/614 (29%)
		MFS	46..>459	CDD:119392	114/427 (27%)
		KAZAL_SLC21	476..529	CDD:238650	17/54 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820