DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and SLCO5A1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_112220.2	Gene:	SLCO5A1 / 81796	HGNCID:	19046	Length:	848	Species:	Homo sapiens

Alignment Length:	666	Identity:	185/666 - (27%)
Similarity:	298/666 - (44%)	Gaps:	103/666 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 MYVIL-----YGLAGCVMT-----MTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAI 121
            :||:|     :.:..|.:|     |...|.:..|||:|:||.:.:..||::....||..::....
Human   120 LYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVF 184

  Fly   122 LGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFL---YGAGEDALQLTREFGQVNETLTNQERDK 183
            :.|:.|...||.|:.:|.|.|.....|.:..||:   |              |:.|...:...|
Human   185 VSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPY--------------QIQELNASAPND- 234

  Fly   184 KLCQPTAGG----------CVQEEVG--LWVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKA 236
            .|||   ||          |.::..|  .||.......||::.|:|....||||..|:|||..|.
Human   235 GLCQ---GGNSTATLEPPACPKDSGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKE 296

  Fly   237 KTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPLIGQEDPRWLGAWWLGWLVLAAITLVS 301
            .:...|::...:..||||:||.|..:.:..|::|.....:.|.|||::|.||.|:|:.|....:.
Human   297 NSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLV 361

  Fly   302 AILLFMFPKQLPSARKRRLQLK------QDERKQSLPLNERSLADMM-------KTVKKLSKNKV 353
            ...:|.|||:||...|::.:.|      .|:.......|....||..       |.|:.|.:..|
Human   362 IFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQADKKVSSMGFGKDVRDLPRAAV 426

  Fly   354 YVYNTMASILYFFGY-------MVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGY 411
            .:.:.|..:.....|       ..:..|.||:||:|:...|:.|::.||.:.:..:..||::.||
Human   427 RILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGY 491

  Fly   412 VISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGSDRLN--------------TLTTLSAGN 462
            :|.|.|..||..|....|...|:   :||:..:...|.:.:|              |:...:...
Human   492 IIKKLKLGARESAKLAMICSGVS---LLCFSTLFIVGCESINLGGINIPYTTGPSLTMPHRNLTG 553

  Fly   463 SCSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDALGRTIYTGCECLGSSSLNSEP----- 522
            ||:.:|.|....|.|||.:|.||:.:.|.|||......:.|...||.|.|:.|..:.:.|
Human   554 SCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCVQSRQVITPPTVGQR 618

  Fly   523 -------------ESQFAVDGTCPVDC--FNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPD 572
                         |:.:||.|.|...|  ...||:||.::.|   :.|.::.:.:::.||.:..:
Human   619 SQLRVVIVKTYLNENGYAVSGKCKRTCNTLIPFLVFLFIVTF---ITACAQPSAIIVTLRSVEDE 680

  Fly   573 EKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSMRYALNLSAAFF 637
            |:.||||:..:....|.:||:||:||.:||..|::|.:.|..:|:||.|:..|.|:.....||..
Human   681 ERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGSCWEYNVTSFRFVYFGLAAGL 745

  Fly   638 IFLGGFLNIAVWYHAK 653
            .|:|.......||..|
Human   746 KFVGFIFIFLAWYSIK 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	176/637 (28%)
		MFS	69..>425	CDD:119392	110/400 (28%)
		KAZAL_SLC21	462..514	CDD:238650	20/51 (39%)
SLCO5A1	NP_112220.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91
		OATP	129..734	CDD:281175	173/628 (28%)
		MFS	131..>531	CDD:119392	114/420 (27%)
		KAZAL_SLC21	551..605	CDD:238650	20/53 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810