DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Da and Slco6c1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_083218.1	Gene:	Slco6c1 / 74441	MGIID:	1921691	Length:	706	Species:	Mus musculus

Alignment Length:	748	Identity:	167/748 - (22%)
Similarity:	286/748 - (38%)	Gaps:	144/748 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KVDLEKSE------------TLPFIEKPFAISDKERESAPENETEGED----GGKDTYCGFWIFK 55
            |.|..|||            |:|..:|.||...|.::|....|....|    ..|:...|.....
Mouse    19 KEDTNKSESEGVTKLQTYLKTIPIAKKKFAKLPKRKKSPTSAELLLIDPRYSASKEGPLGLGPIV 83

  Fly    56 GPSMQRFATEHMYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAA 120
            .|.:|||.....::.||..|..:....||..:.|:...:.::.:......::...:.|::.:.|.
Mouse    84 LPFVQRFNNIDGFMTLYVAAVLIHGALFAVVDMTLNIYQVQFSLTRTEWYLMDFSDYIASFVVAI 148

  Fly   121 ILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYG----------AGEDALQLTREFGQVNET 175
            |:.::....:|.||       |.|.|:|......|:.          .|..:::|..|
Mouse   149 IIAHFGSKGNRTRW-------IAASCILMGLESMLFAFPFFTYEIIIPGRQSIELCME------- 199

  Fly   176 LTNQERDKK--LC---QPTAGGCVQEEVGLWVPQVFLFAAQLISGVGQALFYTLGIAYMDDN--T 233
                |.:|:  :|   .|....|:          .|..|.|.|.|:.....|.|||.::.|:  |
Mouse   200 ----ENEKRNIICGNSVPNRSKCI----------YFHIAGQCIHGIAGMPIYILGITFIFDHIPT 250

  Fly   234 SKAKTPAMLSMSTFLRMLGPAIGYSLAAV-CLRLYIEPTLEPLIGQEDPR----WLGAWWLGWLV 293
            |.......:..|.:|      |||.|..| .|:.:..|..|..:..|..:    ....||..:|:
Mouse   251 SSCGFYLAIGHSAYL------IGYLLGMVGGLQNFQPPPKEKTVEIEPAKVYQLLQSGWWKTFLI 309

  Fly   294 LAAITLVSAILLFMFPKQLPSARKRRLQLKQDERKQSLPLNERSLADM---------MKTVKKLS 349
            :|||:...:.::..||..||.|.|.||.    :||:. |..:|.|.||         :..:..:.
Mouse   310 IAAISFCVSFMMVCFPTSLPGAHKLRLA----KRKEP-PTIDRRLKDMKIQPHLKGFLHNIWHIL 369

  Fly   350 KNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVIS 414
            ||.:.:...:..:..:..:.....|.|.:::||:..:..:|::.||...|.....|..:.|.::.
Mouse   370 KNPLMLTQAICKVSEYLTFNTSLYFLPHHLQTQFLITPGIASLLTGAFVLPGGIIGHFLGGLIVD 434

  Fly   415 KYKPSARAMAAWNAIVDFVTVAGILCYVAIGC------------EGSDRLNTLTTLSAGNSCSAS 467
            :.:.:.:....:..:...|:|...|....:.|            :|..:|..||.     .|:..
Mouse   435 RLEMTNKNKLKFTLVTTVVSVGLFLLIFFVECQTTTFAGINEDYDGYGQLGNLTA-----DCNEY 494

  Fly   468 CHCDYVHYAPVCSADNITFISACHAGCSERTKDALGRTIYTGCECLGSSSLNSEPESQF--AVDG 530
            |.|....|..:|..|...:.|.|.||| :.||.:.....|..|.|:......|:.|.||  |:.|
Mouse   495 CDCTTSLYTSICGRDEKEYFSPCFAGC-KATKVSQTEKTYYNCSCIKEGLAASDDEGQFIDAIAG 558

  Fly   531 TCPVDCFNEFLIF--------LGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASL 587
            ||..||....|.|        ...||.:.::.         :.|:.:|.:..:.:||:.......
Mouse   559 TCDSDCLKLPLFFAFYFSATVFSNMCSIPVIS---------IILQSVPANFTSLSLGVTYAIVKF 614

  Fly   588 LGFIPSPIFFGWLIDNYCLVW-GKTCSNKGNCWLYDTKSMRY---ALNLSAAFFIFLGGFLNIAV 648
            :..:|:|:.|.......|:.| ...|..|..||:|:...:.|   .:.:|:...|.|   |||..
Mouse   615 VASVPAPLLFRLSSAIACIYWDNNRCGGKERCWIYNKNILVYEFMGIWMSSQLIIVL---LNIYA 676

  Fly   649 WYHAKNLKIFD--------EEESSPKDSLKNKE 673
                  ::|.|        |.:::.||..:.||
Mouse   677 ------IQIHDVVVHGEITESKTTVKDVKEQKE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	133/612 (22%)
		MFS	69..>425	CDD:119392	81/386 (21%)
		KAZAL_SLC21	462..514	CDD:238650	16/51 (31%)
Slco6c1	NP_083218.1	OATP	95..654	CDD:281175	133/612 (22%)
		MFS	97..>463	CDD:119392	84/404 (21%)
		KAZAL_SLC21	487..540	CDD:238650	18/58 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810