Protein Alignment Oatp58Da and SLCO1A2

DIOPT Version :9

• Sequence 1: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001373807.1
• Gene: SLCO1A2 / 6579
• HGNCID: 10956
• Length: 670
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 180/678 - (26%)
• Similarity: 313/678 - (46%)
• Gaps: 79/678 - (11%)

  Fly    56 GPSMQRFATEH--------MYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIISVGND 112
            |.:.:|..|..        |:::....|....|::.:|.|..:|.:|:::.|||.:.|.|:...:
Human     2 GETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFE 66

  Fly   113 ISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQLTREFGQVNETLT 177
            |..:|....:.|:....|||..:|||.:.:...|.|.|..|||....|....::......:.:..
Human    67 IGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL 131

  Fly   178 NQERDKKLCQPT--AGGCVQEEVGL-WVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTP 239
            ..|...::.:||  ...|.:|...| |   |::....::.|:|:.....|||:|::|......:|
Human   132 CMENGTQILRPTQDPSECTKEVKSLMW---VYVLVGNIVRGMGETPILPLGISYIEDFAKFENSP 193

  Fly   240 AMLSMSTFLRMLGPAIGYSLAAVCLRLYIEP----TLEPLIGQEDPRWLGAWWLGWLVLAAITLV 300
            ..:.:.....::||.||..||:.|..:|::.    |.:.:|...|.||:||||.|:|:.|.:.::
Human   194 LYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258

  Fly   301 SAILLFMFPKQLPSARKRRLQL--------KQDERKQSLPLNERSLA-DMMKTVKKLSKNKVYVY 356
            :||..|..|..||   |..|:.        .:|::|:.:...:..:. |.:..:|.||.|.:|:.
Human   259 TAIPFFFLPNTLP---KEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYML 320

  Fly   357 NTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSAR 421
            ..:.|::.|..::....|.|||:|.||..|::.|....|...|.....|.:|.|.::.|:|.:.:
Human   321 FILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVK 385

  Fly   422 AMA---AWNAIVDFVTVAGILCYVA--IGCEGSDRLNTLTT-------LSAGN----SCSASCHC 470
            ..|   .|.:::::     :|.:::  :.||.|..:...|:       |...|    .|:..|:|
Human   386 QAAHIGCWLSLLEY-----LLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNC 445

  Fly   471 DYVHYAPVCSADNITFISACHAGCSERTKDALG-RTIYTGCECLGSSSLNSEPESQFAVDGTCP- 533
            ....:.|||..:.::::|||.|||  .|....| ..::..|.|:.:|..:|      ||.|.|.
Human   446 PSKIWDPVCGNNGLSYLSACLAGC--ETSIGTGINMVFQNCSCIQTSGNSS------AVLGLCDK 502

  Fly   534 -VDC---FNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSP 594
             .||   ...|||...:..|:..:.|   ....::.||||..:||:..:||.:....:...||:|
Human   503 GPDCSLMLQYFLILSAMSSFIYSLAA---IPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAP 564

  Fly   595 IFFGWLIDNYCLVWGK-TCSNKGNCWLYDTKSMRYA-LNLSAAF--FIFLGGFLNIAVWYHAKNL 655
            |:||.|:|:.||.||. .|...|.|.:||:.:.||. |.|.||.  ..|:...:.:.:   .:..
Human   565 IYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILIL---LRKC 626

  Fly   656 KIFDEEESSPKD----SLKNKEVEMKTI 679
            .:..|..||..:    .:|.||.|.|.|
Human   627 HLPGENASSGTELIETKVKGKENECKDI 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	161/597 (27%)
		MFS	69..>425	CDD:119392	98/374 (26%)
		KAZAL_SLC21	462..514	CDD:238650	17/56 (30%)
SLCO1A2	NP_001373807.1	oat	1..625	CDD:273279	171/647 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820