Protein Alignment Oatp58Da and Slco1b2

DIOPT Version :10

• Sequence 1: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_113838.1
• Gene: Slco1b2 / 58978
• RGDID: 69300
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 718
• Identity: 181/718 - (25%)
• Similarity: 319/718 - (44%)
• Gaps: 113/718 - (15%)

  Fly    27 DKERESAPENETEGEDGGKDTYC-GFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTFAYFNGTI 90
            |..::|....|.:.....:..:| ||.:|       .|......|...|.|.||       ..:|
  Rat     2 DHTQQSRKAAEAQPSRSKQTRFCDGFKLF-------LAALSFSYICKALGGVVM-------KSSI 52

  Fly    91 TTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFL 155
            |.:|:|:.||:.:||:|..|.:|..:|....:.|:....|||:.:|||...:....:||:..||.
  Rat    53 TQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGSILTALPHFF 117

  Fly   156 YGAGEDALQLTREFGQV-NETLT---NQERDKKLCQPTA-------GGCVQEEVGL----WVPQV 205
            .|..:.|.:  .:.|.: |.|||   ||     :..||.       .||   |.||    |   :
  Rat   118 MGYYKYAKE--NDIGSLGNSTLTCFINQ-----MTSPTGPSPEIVEKGC---EKGLKSHMW---I 169

  Fly   206 FLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEP 270
            ::....::.|:|:.....|||:|:||...:..|...|.....:.|:||.:|:.:::|..::|::.
  Rat   170 YVLMGNMLRGIGETPIVPLGISYLDDFAKEGHTSMHLGTLHTIAMIGPILGFIMSSVFAKIYVDV 234

  Fly   271 TLEPL----IGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLP----SARKRRLQL---KQ 324
            ....|    |...|.||:|||||.::|...:.:.|:|..|..|| :|    ..||..:.|   |.
  Rat   235 GYVDLNSVRITPNDARWVGAWWLSFIVNGLLCITSSIPFFFLPK-IPKRSQEERKNSVSLHAPKT 298

  Fly   325 DERKQSL----------PLNERSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYI 379
            ||.|:.:          |.|   :...:::::.:..|::||...:.::|...|::..:.:..|:|
  Rat   299 DEEKKHMTNLTKQEEQDPSN---MTGFLRSLRSILTNEIYVIFLILTLLQVSGFIGSFTYLFKFI 360

  Fly   380 ETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAI 444
            |.|:.::|:.|....|.:.:...|..:.:.||::.|:|.::..:|.:......|..|....|..:
  Rat   361 EQQFGRTASQANFLLGIITIPTMATAMFLGGYIVKKFKLTSVGIAKFVFFTSSVAYAFQFLYFPL 425

  Fly   445 GCEGSDRLNTLTTLSAGNS-----------CSASCHCDYVHYAPVCSADNITFISACHAGC-SER 497
            .||.........|....|.           |::.|.||...:.|:|..:.:|:||.|.||| |.|
  Rat   426 LCENKPFAGLTLTYDGMNPVDSHIDVPLSYCNSDCSCDKNQWEPICGENGVTYISPCLAGCKSFR 490

  Fly   498 TKDALGRTIYTGCECLGSSSLNSEPESQFAVDGTCP-VDCFNEFLIFLGVMCFLKLVGASSKSTN 561
            .......|.:..|.|:.:|..||      |..|.|| ..|...:..::.:...:....|....:.
  Rat   491 GDKKPNNTEFYDCSCISNSGNNS------AHLGECPRYKCKTNYYFYIILQVTVSFFTAMGSPSL 549

  Fly   562 LLLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKT-CSNKGNCWLYDTKS 625
            :|:.::.:.|:.|:.|:|..|:....||.|.:||::|..||..|:.|..| |..:|.|.||:::.
  Rat   550 ILILMKSVQPELKSLAMGFHSLIIRALGGILAPIYYGAFIDRTCIKWSVTSCGKRGACRLYNSRL 614

  Fly   626 MRYA---LNL---SAAFFIFLGGFLNIAVWYHAKNLKIFDEEESSPKDSLKNKEVE---MKTIDS 681
            ..::   |||   :...|:::     :.:::..:..|..|           ||.:|   ..|.:.
  Rat   615 FGFSYLGLNLALKTPPLFLYV-----VLIYFTKRKYKRND-----------NKTLENGRQFTDEG 663

  Fly   682 NPE 684
            ||:
  Rat   664 NPD 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	161/608 (26%)
Slco1b2	NP_113838.1	MFS	28..555	CDD:475125	142/563 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..311		7/24 (29%)