DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and Slco1c1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_067446.1	Gene:	Slco1c1 / 58807	MGIID:	1889679	Length:	715	Species:	Mus musculus

Alignment Length:	726	Identity:	196/726 - (26%)
Similarity:	325/726 - (44%)	Gaps:	113/726 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SDKERESAPENETEGEDGGKDTYCGFWIFKGPSMQ--RFATEHMYVILYGLAGCVMTMTFA--YF 86
            |.||........:....||.....|:     ||.:  |.....:.|.|..|:........|  |.
Mouse     4 SSKENAHLFHKNSAQPAGGPSFTVGY-----PSTEEARPCCGKLKVFLGALSFVYFAKALAEGYL 63

  Fly    87 NGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAF--CLLT 149
            ..|:|.:|:|::||:.:.|||....:|..:|....:.|:....|||:.:|.|.| ::.|  .|:.
Mouse    64 KSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCL-VMGFGTMLIA 127

  Fly   150 SSLHFLYGAGEDALQLTREFGQVNETLTNQERDKKLCQPT----------AGGCV-QEEVGLWVP 203
            ....|:.....:..:.......|..:::....:.....|:          :..|| .....:|
Mouse   128 VPQFFMEKYSYEKYERYSPSSNVTPSISPCYLESSSPSPSSILGKSQNKISHECVGDSSSSMW-- 190

  Fly   204 QVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYI 268
             |::|...|:.|:|:.....|||||:||..|:......:.....:.::||..|:.|.::|.:||:
Mouse   191 -VYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYV 254

  Fly   269 E--------PTLEPLIGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARKRRLQLKQD 325
            :        .|:.|    :||:|:||||||:|:...::|::|:..:..||.||.::.|.......
Mouse   255 DIGFVNLDHITITP----KDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSRENSGSTS 315

  Fly   326 ERK---------QSLPLNER-----SLADMMKTVKKLSKNKVYVYNTMASILYF---FGYMVYWI 373
            |:.         |..|.:::     ...|.:.::|.|.:|.||:....||.:.|   ||.:.|
Mouse   316 EKSKFIDDPIHYQMAPGDDKMKIMEMAKDFLPSLKTLFRNPVYILYLCASTVQFNSLFGMVTY-- 378

  Fly   374 FTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFV--TVA 436
             .|||||.||.||::.|....|.:.:...|.||...|.|:.|::     :....|...::  :|.
Mouse   379 -KPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFR-----LGICEATKLYLGSSVF 437

  Fly   437 GILCYV---AIGCEGSDRLNTLTTLSAG------------NSCSASCHCDYVHYAPVCSADNITF 486
            |.|.::   |:|||.|. :..||....|            :.|::.|.|....:.|:|..:.||:
Mouse   438 GYLLFLSLFALGCENSS-VAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITY 501

  Fly   487 ISACHAGCSERTKDALGRT-IYTGCECLGSSSLNSEPESQFAVDGTCPVD--CFNEFLIFLGVMC 548
            :|||.|||...::.  |:. |::.|.|:|.::..|...|  .:.|.|..|  |...||.||.:..
Mouse   502 VSACLAGCQSSSRS--GKNIIFSNCTCVGFAAPKSGNWS--GMMGRCQKDNGCSQMFLYFLVISV 562

  Fly   549 FLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWG-KTC 612
            ......:.......:|.|||:.|..|:||||:.::|..:|..||:|::||.|||..||.|| |.|
Mouse   563 ITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKC 627

  Fly   613 SNKGNCWLYDTKSMRYALNLSAAFFIFLG---------GFLNIAVW------YHAKNLKIFDEEE 662
            .::|:|.|||:.:.|:         |:||         .||::||.      |.:|:..:....|
Mouse   628 GSRGSCRLYDSHAFRH---------IYLGLTTLLGTVSVFLSMAVLFVLKKKYVSKHSSLITTRE 683

  Fly   663 SSPKDSLKNKE 673
            .....|...||
Mouse   684 KIGMSSSIKKE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	173/619 (28%)
		MFS	69..>425	CDD:119392	102/395 (26%)
		KAZAL_SLC21	462..514	CDD:238650	17/52 (33%)
Slco1c1	NP_067446.1	OATP	44..641	CDD:281175	173/617 (28%)
		MFS	46..>302	CDD:119392	66/263 (25%)
		KAZAL_SLC21	475..528	CDD:238650	17/54 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810