DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and slco3a1a

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001038653.1	Gene:	slco3a1a / 569735	ZFINID:	ZDB-GENE-030131-8662	Length:	701	Species:	Danio rerio

Alignment Length:	721	Identity:	193/721 - (26%)
Similarity:	327/721 - (45%)	Gaps:	109/721 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KERESAPENETEGEDGGKDTYCGFWIFKGPSMQRFATEHMYVILYGLAGCVMTM----TFAYFNG 88
            |:|.|        ||..:|.     |.|.||.  |:...::::    |.|.:.:    ..||...
Zfish     5 KQRSS--------EDPQRDD-----IKKKPSC--FSNIKIFLV----AECALMLAQGTVGAYLVS 50

  Fly    89 TITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLH 153
            .:||||:|:.:.:...|:|:...:|..:.....:.|:....||||.:|.|.:.:....||::...
Zfish    51 VLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGAKAHRPRLIGCGGIVMALGALLSALPE 115

  Fly   154 FLYGAGEDALQLTREFGQVNETLTNQERDKKLCQPTAGGCVQEEVGLWVPQVFLFAAQLISGVGQ 218
            ||  |.:..:..|....|..:..:|..:..:.|...|...:.        .:.|..||::.|:|.
Zfish   116 FL--ASQYKITDTWSKDQGRDVCSNTSKADEPCGNRANTNMM--------YLLLIGAQVLLGIGA 170

  Fly   219 ALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIE----PTLEPLIGQE 279
            .....||::|:||:..|..:...:.:.....:.|||.|:.|.:||...|::    .|.:..|..:
Zfish   171 TPVQPLGVSYIDDHVRKKDSSLYIGILFSTLVFGPACGFILGSVCTNFYVDALFIDTTQLNITPD 235

  Fly   280 DPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARKRRL----------QLKQDERK------ 328
            ||||:||||.|:|:..|:...||:.:|.||:.|||.....:          .|.||..|
Zfish   236 DPRWIGAWWGGFLICGALLFFSALFMFGFPQSLPSKEMEGVPESEQAMLPASLSQDFEKSKPSNG 300

  Fly   329 --QSLPLNERSLA--DMMKTVKKLSK----NKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQ 385
              |:...|..||:  ..::.:.|::|    |.|:....:|:.:.......:..|..||:|.|:..
Zfish   301 VVQNYQPNSNSLSCCQQLRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNL 365

  Fly   386 SAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVA---IGCE 447
            :.:.|....|..|:..:..||.:.|.::.|...||........:|:.::.|   |||:   :||:
Zfish   366 TTSSANQLLGMTAIPCACLGIFLGGLLVKKLNLSALGAIRMAMLVNLISTA---CYVSFLFLGCD 427

  Fly   448 -----------GSDRLNTLTTLSAGNSCSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDA 501
                       |::.|....|..|  .|.:.|:|.....:|||.::.:|::|:|.|||:......
Zfish   428 TGPVAGVTVAYGNETLQVGQTPEA--PCMSHCNCYTSSVSPVCGSNGVTYLSSCFAGCTRAISTG 490

  Fly   502 LGRTI---YTGCECLGSSSLNSEPESQFAVDGTCP-VDCFNEFLIFLGVMCFLKLVGASSKSTNL 562
            |...:   .:||.|:  |..|   :...||.|.|| ..|...||.||.|:|...::||.:::.::
Zfish   491 LPAPLSQNLSGCACI--SGYN---DFATAVPGKCPRPGCQEAFLTFLCVICGCSMIGAMAQTPSV 550

  Fly   563 LLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSMR 627
            ::.:|.:.|:.|::|||:..:...||||||.|:.||..||:.||.|...|..||.|.|||..:.|
Zfish   551 IILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSAECGVKGACLLYDNVTYR 615

  Fly   628 YALNLSAAFFIFLGGFLNIAVWYHA---------KNL-------KIFDEE---ESSPKDSLKNKE 673
            : |.:|.|..:.:..||.....:|.         ||:       ::|...   :|..|||.:::.
Zfish   616 H-LYISMAIVLKIMAFLLYTTTWHCLRRNYKKYIKNIEGYLTPTEVFSSSMNLDSLGKDSSQSQV 679

  Fly   674 VEMKTI 679
            ...|.|
Zfish   680 NRTKFI 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	166/608 (27%)
		MFS	69..>425	CDD:119392	96/387 (25%)
		KAZAL_SLC21	462..514	CDD:238650	16/54 (30%)
slco3a1a	NP_001038653.1	OATP	29..614	CDD:281175	166/608 (27%)
		MFS	35..>265	CDD:119392	63/239 (26%)
		KAZAL_SLC21	449..506	CDD:238650	17/60 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750