DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and slco1c1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_005164528.1	Gene:	slco1c1 / 562772	ZFINID:	ZDB-GENE-041210-50	Length:	710	Species:	Danio rerio

Alignment Length:	679	Identity:	191/679 - (28%)
Similarity:	310/679 - (45%)	Gaps:	92/679 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KERESAPENETEGEDGGKDTYCGFWIFKGPSMQRFATEH-------------MYVILYGLAGCVM 79
            ||..|..|||           ...|....|:.:|.:.|:             |:::....|....
Zfish     7 KESSSPKENE-----------IFLWRMDLPNKERRSPENSPSSSRRCCSSFKMFLVALSFAYFSK 60

  Fly    80 TMTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVA 144
            .::.:|...|||.||:|:.||:.:.|:|....:|..:|..|.:.|:....|||:.:.||.|.:..
Zfish    61 ALSGSYMKSTITQLERRFDIPSYLIGVIDGSFEIGNLLVIAFVSYFGAKLHRPKIIAIGCLLMSL 125

  Fly   145 FCLLTSSLHFLYG--AGEDALQLTREFGQVNETLTNQERDKKLCQPTAG-----GCVQE-EVGLW 201
            ...|.:..||:.|  ..|.:::|:     ||.:.:.........:|:..     ||..| .:.:|
Zfish   126 GTFLIALPHFIIGRYKFETSIRLS-----VNSSSSLSPCSLSSAEPSTSSVPSTGCEHESRLSMW 185

  Fly   202 VPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRL 266
               :::|...::.|:|:.....|||:|:||:..:......:.....:.::||..||.|.:||.::
Zfish   186 ---IYVFLGNILRGIGETPVQPLGISYIDDHALEENAAFYIGCVQTISVIGPVFGYLLGSVCAKI 247

  Fly   267 YIE---PTLEPL-IGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARKRRLQLKQDER 327
            |::   ..:|.: |...|.||:||||||:|:...|||:||:..:..||.|| ..:|||.....||
Zfish   248 YVDIGFVNMESISITPGDARWVGAWWLGYLIAGFITLLSAVPFWFLPKSLP-LPERRLSKYSPER 311

  Fly   328 KQSL--------------PLNERSLA-DMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPK 377
            ...:              |.|...:| |.:.|::.|..|.||......:|:.|...:....:.||
Zfish   312 NSFIKDSALLEHKYQADEPANFLEMAKDFLPTLRSLLGNPVYFLYLCVTIIQFNSLIGMVTYKPK 376

  Fly   378 YIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYV 442
            |||..|.|||:.|....|.:.:...|.|:...|.::.|:|.|....|.:......:.....|.:.
Zfish   377 YIEQHYGQSASKANFLMGVINIPAVALGMFSGGVIMKKFKLSIMGAAKFALGTSLLGYFLSLFFF 441

  Fly   443 AIGCE------------GSDRLNTLTTLSAGNSCSASCHCDYVHYAPVCSADNITFISACHAGCS 495
            ::|||            |::.| .:...|...||:|:|||...::.|||..|.:|::|.|.|||
Zfish   442 SMGCENASVAGITMSYNGTESL-FMADGSLRASCNAACHCPEKNWDPVCGEDGLTYVSPCLAGC- 504

  Fly   496 ERTKDALGR-TIYTGCECLGSSSLNSEPESQFAVDGTC--PVDCFNEFLIFLGVMCFLKLVGASS 557
             ||....|. |::..|.|:|..       :|.|..|.|  ...|...|..||.:......:.:..
Zfish   505 -RTSHGSGMDTVFEQCSCIGVG-------NQTATAGQCNNRESCHRIFPYFLALSVITSFIISLG 561

  Fly   558 KSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWG-KTCSNKGNCWLY 621
            .:...:|.:||:.|..|:.|||..::....|..||:||:||.:||..||.|| |.|..:|.|.:|
Zfish   562 GTPGYMLLIRCIKPQLKSLALGFHTLTTRTLAGIPAPIYFGAIIDTTCLKWGHKKCGGRGACRIY 626

  Fly   622 DTKSMRYA-----LNL-SAAFFIFLGGFL 644
            :|.:.|.|     |.| :.:||:.:.|.|
Zfish   627 NTAAYRIAYLGLTLGLRTVSFFLCILGLL 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	173/601 (29%)
		MFS	69..>425	CDD:119392	106/382 (28%)
		KAZAL_SLC21	462..514	CDD:238650	22/52 (42%)
slco1c1	XP_005164528.1	OATP	48..631	CDD:281175	173/601 (29%)
		MFS	50..461	CDD:119392	112/419 (27%)
		KAZAL_SLC21	470..523	CDD:238650	22/54 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820