DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and LOC556735

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_684701.3	Gene:	LOC556735 / 556735	-ID:	-	Length:	859	Species:	Danio rerio

Alignment Length:	712	Identity:	198/712 - (27%)
Similarity:	322/712 - (45%)	Gaps:	120/712 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GGKDTYCGFWIFKGPSMQRF-ATEHMYVIL-----YGLAGCVMT-----MTFAYFNGTITTLEKR 96
            |||.  .||.:.:   :.|| ..:::.|||     :....|.:|     |...|.:..|||:|||
Zfish   114 GGKK--LGFSLAR---LIRFPVRKYLRVILSDSRCFLFCMCYLTFIQSLMVSGYLSSVITTIEKR 173

  Fly    97 YKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFL---YGA 158
            |.:.:..||::....||.::|....:.|:.|...||||:.:|.:.|.....|.|..||:   |
Zfish   174 YSLRSSESGLLVSCFDIGSLLVVVFISYFGGRGQRPRWLAVGGVFIAVGAALFSLPHFISPPY-- 236

  Fly   159 GEDALQLTREFGQVNETLTNQ--------ERDKKLCQPTAGGCVQEEVG----LWVPQVFLFAAQ 211
                     :..:||.::.|:        .||..    ....|.:::.|    ::|  .....||
Zfish   237 ---------QIKEVNSSMGNEGLCLNGNRSRDAL----DVSSCPRDQEGNDHSIYV--ALFVCAQ 286

  Fly   212 LISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPLI 276
            ::.|:|....||||..|:|||..|......|::...:..||||.||.|..|.:..|::|.....|
Zfish   287 VLVGMGSTPIYTLGPTYLDDNVKKENASLYLAIMYVMGALGPAAGYLLGGVLIGFYVDPKTIVNI 351

  Fly   277 GQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARKRR----------------LQLKQD 325
            .|.|||::|.||.|:|:.|...|:....:|.|||:||...|::                |:.|.:
Zfish   352 EQSDPRFVGNWWSGFLLCAFAMLLVIFPMFTFPKKLPPRHKKKKKKHAADSASNDDDDVLKEKSN 416

  Fly   326 ERKQSLPLN---ERSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSA 387
            .:.|::..:   .|.:.|:.|...::..|..:::.:::..........:..|.||:||:|:...|
Zfish   417 SKGQTVASSMGFGRDIKDLPKAAIRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPA 481

  Fly   388 AMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGSDRL 452
            :.|::.||.:.:..:..||::.||:|.|.|..||..|....|...|:   :||:..:...|.:.:
Zfish   482 SNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVS---LLCFSTLFIVGCESI 543

  Fly   453 N--------------TLTTLSAGNSCSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDALG 503
            |              |||..:....|:.:|.|....|||||.:|.||:.:.|.||||....|:.|
Zfish   544 NLGGINIPYTTGPTLTLTHRNLTGGCNVNCGCRINEYAPVCGSDGITYFNPCLAGCSTVGNDSTG 608

  Fly   504 RTIYTGCECLGSSSLNSEP------------------ESQFAVDGTCPVDCFNEFLIFLGVMCFL 550
            ...||.|.|:.|..:.:.|                  |:.||:.|.|...| |..:.||..:..:
Zfish   609 IRNYTDCACVQSRQVITPPTSGQGNQLQLVIVKTYLNENGFALSGKCDRTC-NTLIPFLIFLFIV 672

  Fly   551 KLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKTCSNK 615
            .|:.|.::.:.:::.||.:...|:.||||:..:....|.:||:||:||.:||..|::|.:.|...
Zfish   673 TLITACAQPSAIIVTLRSVDEQERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQDCGIH 737

  Fly   616 GNCWLYDTKSMRYALNLSAAFFIFLGGFLNIAVWYHAKNLKIFDEEESSPKDSLKNKEVEMK 677
            |:||.||..|.|:.....||...|:|.......||                 |:|.||..:|
Zfish   738 GSCWEYDVTSFRFVYFGLAASLKFVGFIFIFLTWY-----------------SIKYKEDRLK 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	178/634 (28%)
		MFS	69..>425	CDD:119392	109/399 (27%)
		KAZAL_SLC21	462..514	CDD:238650	22/51 (43%)
LOC556735	XP_684701.3	OATP	143..748	CDD:281175	175/625 (28%)
		MFS	146..>545	CDD:119392	112/418 (27%)
		KAZAL_SLC21	565..619	CDD:238650	22/53 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810