Protein Alignment Oatp58Da and Slco1a1

DIOPT Version :10

• Sequence 1: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_058807.1
• Gene: Slco1a1 / 50572
• RGDID: 3700
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 686
• Identity: 182/686 - (26%)
• Similarity: 313/686 - (45%)
• Gaps: 90/686 - (13%)

  Fly    60 QRFATEH------MYVILYGLAGCVMTMTFA--YFNGTITTLEKRYKIPTKVSGIISVGNDISTM 116
            ::.||:.      |.|.|..|....:|.:.:  |.|..:|.:|:::.|.|.|:|:|:...:|..:
  Rat     6 KKIATQEGRLFSKMKVFLLSLTCACLTKSLSGVYMNSMLTQIERQFDISTSVAGLINGSFEIGNL 70

  Fly   117 LTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQLTREFGQVNETLTNQER 181
            .....:.|:....|||..:|||.:.:...|||.|..||..|..|....::......:.:....|.
  Rat    71 FFIVFVSYFGTKLHRPVVIGIGCVIMGLGCLLMSLPHFFMGRYEYETTISPTGNLSSNSFLCMEN 135

  Fly   182 DKKLCQPT--AGGCVQEEVGL-WVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLS 243
            ..:..:||  ...||:|...| |   :.:....:|.|:|:.....|||:|::|......:|..:.
  Rat   136 RTQTLKPTQDPAECVKEMKSLMW---ICVMVGNIIRGIGETPIVPLGISYIEDFAKSENSPLYIG 197

  Fly   244 MSTFLRMLGPAIGYSLAAVCLRLYIE----PTLEPLIGQEDPRWLGAWWLGWLVLAAITLVSAIL 304
            :....::.||..|..|.:.|.::|::    .|.:..|...|.||:||||:|:||.|.:.::::|.
  Rat   198 ILEMGKVAGPIFGLLLGSYCAQIYVDIGSVNTDDLTITPSDTRWVGAWWIGFLVCAGVNILTSIP 262

  Fly   305 LFMFPKQLP-SARKRRLQLKQD---------ERKQSLPLNERSLADMMKTVKKLSKNKVYVYNTM 359
            .|..||.|| ..::..:.:.:|         .|:::|.:.:    |.:..:|:|..|.:|:...:
  Rat   263 FFFLPKALPKKGQQENVAVTKDGKVEKYGGQAREENLGITK----DFLTFMKRLFCNPIYMLFIL 323

  Fly   360 ASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMA 424
            .|:|...|::..:.|.|||:|.||.:|.|.|....|..:|.....|.||.|:::.|:|.:.:..|
  Rat   324 TSVLQVNGFINKFTFLPKYLEQQYGKSTAEAIFLIGVYSLPPICLGYLIGGFIMKKFKITVKKAA 388

  Fly   425 AWNAIVDFVTVAGILCYVAIGCEGSDRLNTLTTLSAG------------NSCSASCHCDYVHYAP 477
            .....:........||:..:.|:.: .:..|||...|            ..|:..|.|....:.|
  Rat   389 YLAFCLSVFEYLLFLCHFMLTCDNA-AVAGLTTSYKGVQHQLHVESKVLADCNTRCSCSTNTWDP 452

  Fly   478 VCSADNITFISACHAGCSERTKDALG---RTIYTGCEC---LGSSSLNSEPESQFAVDGTCP--V 534
            ||..:.:.::|||.|||    |..:|   ..::..|.|   ||:||         ||.|.|.  .
  Rat   453 VCGDNGVAYMSACLAGC----KKFVGTGTNMVFQDCSCIQSLGNSS---------AVLGLCKKGP 504

  Fly   535 DCFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGW 599
            :|.|....||.:...:..:.:.:.....::.|||:..:||:..:||.:....:...||:|::||.
  Rat   505 ECANRLQYFLILTIIISFIYSLTAIPGYMVFLRCVKSEEKSLGVGLHTFCIRVFAGIPAPVYFGA 569

  Fly   600 LIDNYCLVWGK-TCSNKGNCWLYDTKSMRY-------ALNLSA---AFFIFL-------GGFLNI 646
            |||..||.||. .|..:|.|.:||..|.|:       ||..|:   ||||.:       .|.::.
  Rat   570 LIDRTCLHWGTLKCGQRGACRMYDINSFRHIYLGLPIALRGSSYLPAFFILILMRKFQFPGDIDS 634

  Fly   647 AVWYHAKNLKIFDEEESSPKDSLKNKEV----EMKT 678
            :...|.:  .:..|:||...|...:.:|    |:||
  Rat   635 SATDHTE--MMLGEKESEHTDVHGSPQVENDGELKT 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	161/598 (27%)
Slco1a1	NP_058807.1	oat	1..625	CDD:273279	172/639 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..670		8/24 (33%)