DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and Oatp58Dc

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	382/752 - (50%)
Similarity:	497/752 - (66%)	Gaps:	86/752 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EERGKVDLEKSETLPFIEKPFAISDKERESAPE--------NETEGEDG-GKDTYCGFWIFKGPS 58
            :|.|..|.|  ||.|...|    |.|:::.:.:        |:...|.. .|:..||||||||..
  Fly    45 KEAGNQDGE--ETTPKTGK----SKKKKQKSEQDRLMTAEINKLLAESPLEKNVTCGFWIFKGTF 103

  Fly    59 MQRFATEHMYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILG 123
            .||||.:..||:|||:.||:.:||:|||||||||:|||:|||:|.:||||||||||..|.:|:|.
  Fly   104 YQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLA 168

  Fly   124 YYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQLTREFGQV---NETL--TNQERDK 183
            ||||..|||||:|.||||||.||:||::.|||||.|||||.||.|||.:   |.|:  ..::|.|
  Fly   169 YYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQRSK 233

  Fly   184 KLCQPTAGG--CVQEEVGLWVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMST 246
            .||:...||  |...| |.:.||:.||.||.|||:|.:|:||||::||||||.|:||||:||:|.
  Fly   234 TLCRLNGGGAECEVGE-GNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSY 297

  Fly   247 FLRMLGPAIGYSLAAVCLRLYIEPTLEPLIGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQ 311
            |||||||||||:||:.||||||.|.:.|:|..:||||||||||||||:..:...|.:.|.||||:
  Fly   298 FLRMLGPAIGYALASFCLRLYIAPQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKE 362

  Fly   312 LPSA------------RKRRLQLKQDERKQ-SLPLNERSLA-------DMMKTVKKLSKNKVYVY 356
            ||.|            .|.||.:|..|::: :..|::::.|       ||:||.::|..||.|:.
  Fly   363 LPRAVARRKVEENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMC 427

  Fly   357 NTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSAR 421
            ||::||.|..||..||||||||||.|||||||.::|.||||||.|||.|:|:||::||:|||.||
  Fly   428 NTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRAR 492

  Fly   422 AMAAWNAIVDFVTVAGILCYVAIGCEGSDR---LNTLTTLSAGN--SCSASCHCDYVHYAPVCSA 481
            .|||||.||.|:||||||.|..|||.|::.   :|...:..|||  :|:::|.||||.|:|||..
  Fly   493 YMAAWNVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDSSLAGNTTTCNSACSCDYVRYSPVCGE 557

  Fly   482 DNITFISACHAGCSERTKDALGRTIYTGCECLGSS----------------------SLNSEPES 524
            :|:|:||||||||.:...::.|:.|:..|.|:.|.                      |.|:...|
  Fly   558 NNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHS 622

  Fly   525 QF-------AVDGTCPVDCFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGS 582
            |.       |:.|.|||:|:.:|:.||.|||.||.||||.:::|.|:::||:|..:||.|:|.|.
  Fly   623 QLEALANGQAMPGACPVNCWTQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGM 687

  Fly   583 MAASLLGFIPSPIFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSMRYALNLSAAFFIFLGGFLNIA 647
            ...|:|.||||||||||:.|..||||||||:|||||||||..||||.||.:||.||.:|...::.
  Fly   688 TLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLG 752

  Fly   648 VWYHAKNLKIFDEEESSPKDSLKNKEVEMKTIDSNPE 684
            |||:||:||||||:.         ||||||.:....|
  Fly   753 VWYYAKDLKIFDEDV---------KEVEMKIVQHEEE 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	328/619 (53%)
		MFS	69..>425	CDD:119392	218/382 (57%)
		KAZAL_SLC21	462..514	CDD:238650	25/53 (47%)
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	328/619 (53%)
		MFS	114..>518	CDD:119392	234/404 (58%)
		KAZAL_SLC21	537..590	CDD:238650	24/52 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28658
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	1	1.000	-	-		FOG0012696
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
	10	9.760