DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and SLCO4C1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_851322.3	Gene:	SLCO4C1 / 353189	HGNCID:	23612	Length:	724	Species:	Homo sapiens

Alignment Length:	691	Identity:	191/691 - (27%)
Similarity:	311/691 - (45%)	Gaps:	101/691 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IEKPFAISDKERE----------------------SAPENETEG----------EDGGKDTYCGF 51
            ||.....||.:||                      |||.|.:|.          |:|   :| |:
Human    30 IEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEG---SY-GW 90

  Fly    52 WIFKGPSMQRFATEHMYVILYGLAGCVMTMTFA-YFNG----TITTLEKRYKIPTKVSGIISVGN 111
            ..|....:||..|...:::.|    |::.:|.. ..||    :|:|:||||::.:.::|:||...
Human    91 RNFHPQCLQRCNTPGGFLLHY----CLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSY 151

  Fly   112 DISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQLTREFGQVNETL 176
            |||..|.:..:.::....|:|||:......|....|:.|...|.  :||..|      |.:.|..
Human   152 DISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFF--SGEYKL------GSLFEDT 208

  Fly   177 TNQERDKKLCQPTAGGCVQEEVGLWVPQVFLF-AAQLISGVGQALFYTLGIAYMDDNTSKAKTPA 240
            ....|:...|..:......        .:::| ..||:.|.|....||||.|::||:....|:..
Human   209 CVTTRNSTSCTSSTSSLSN--------YLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSL 265

  Fly   241 MLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTL--EPLIGQEDPRWLGAWWLGWLVLAAITLVSAI 303
            .:.....:.:|||||||.|....|.:||:..:  ...:.::|||||||||:|:| |:.|...|.|
Human   266 YIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFL-LSWIFAWSLI 329

  Fly   304 LLF-MFPKQLPSARK----RRLQLKQDERKQSLPLNERSLADMMKTVKKLSKNKVY---VYNTMA 360
            :.| .|||.||...:    :..|..|......:... :|:.|....:|.|.||.|:   |.:|.:
Human   330 IPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKFG-KSIKDFPAALKNLMKNAVFMCLVLSTSS 393

  Fly   361 SILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAA 425
            ..|...|:..   |.||:||.|:..:::.|....|.|.:..:|.|.::.|:::||::.:.:....
Human   394 EALITTGFAT---FLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMK 455

  Fly   426 WNAIVDFVTVAGILCYVAIGCEG------SDRLNTLTTLSAGN---SCSASCHCDYVHYAPVCSA 481
            :......|.:.....::...||.      |:..|  .|...||   .|:|:|:|...:|.||| .
Human   456 FALFTSGVALTLSFVFMYAKCENEPFAGVSESYN--GTGELGNLIAPCNANCNCSRSYYYPVC-G 517

  Fly   482 DNITFISACHAGCSERTKDALGRTIYTGCECLGSSSLNSEPESQFAVD---GTCPVDCFNEFLIF 543
            |.:.:.|.|.||||........: :|..|.|:...:..:.....|..:   |.|...| .:..||
Human   518 DGVQYFSPCFAGCSNPVAHRKPK-VYYNCSCIERKTEITSTAETFGFEAKAGKCETHC-AKLPIF 580

  Fly   544 LGVMCFLKLVGASSKSTNLLLA-LRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLV 607
            |.:. |:.::......|.:.:: |||:...:::.|||:..|...|||.||.||.||:.||:.|::
Human   581 LCIF-FIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCIL 644

  Fly   608 WG-KTCSNKGNCWLYDTKSMRY---ALNLSA-AFFIFLGGF 643
            |. ..|..||.||:||...|.:   |::::. ...:|..||
Human   645 WDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGF 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	167/588 (28%)
		MFS	69..>425	CDD:119392	105/371 (28%)
		KAZAL_SLC21	462..514	CDD:238650	19/54 (35%)
SLCO4C1	NP_851322.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..71		10/40 (25%)
		OATP	106..664	CDD:281175	167/588 (28%)
		MFS	124..>485	CDD:119392	104/381 (27%)
		KAZAL_SLC21	499..549	CDD:238650	18/51 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810