DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and Slco1b2

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_065241.1	Gene:	Slco1b2 / 28253	MGIID:	1351899	Length:	689	Species:	Mus musculus

Alignment Length:	692	Identity:	180/692 - (26%)
Similarity:	304/692 - (43%)	Gaps:	93/692 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KDTYC-GFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIIS 108
            |..:| ||.||       .|......|...|.|.:|       ..:||.:|:|:.||:.:||:|.
Mouse    18 KTRHCDGFRIF-------LAALSFSYICKALGGVIM-------KSSITQIERRFDIPSSISGLID 68

  Fly   109 VGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYG----AGEDALQLTREF 169
            .|.:|..:|....:.|:....|||:.:|.|...:....:||:..||..|    |.|:.:....
Mouse    69 GGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALPHFFMGYYRYATENDISSLH-- 131

  Fly   170 GQVNETLT---NQERDKKLCQP--TAGGCVQEEVG----LWVPQVFLFAAQLISGVGQALFYTLG 225
               |.|||   ||........|  ...||   |.|    .|   :::....::.|:|:.....||
Mouse   132 ---NSTLTCLVNQTTSLTGTSPEIMEKGC---EKGSNSYTW---IYVLMGNMLRGIGETPIVPLG 187

  Fly   226 IAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPL----IGQEDPRWLGA 286
            ::|:||...:..:...|.....:.|:||.:|:.:::|..:||::.....|    |..:|.||:||
Mouse   188 VSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGA 252

  Fly   287 WWLGWLVLAAITLVSAILLFMFPKQLPSARKRRLQ------LKQDERKQSL--PLNER-----SL 338
            ||||::|...:.::.:|..|..||....::|.|..      ||.||.|..:  |..:.     :|
Mouse   253 WWLGFIVNGLLCIICSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEKQAPANL 317

  Fly   339 ADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSA 403
            ...:.:::.:..|:.||...:.::|....::..:.:..|:||.|:.|:|:.|....|.:.:...|
Mouse   318 TGFLWSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMA 382

  Fly   404 AGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGSDRLNTLTTLSAGNS----- 463
            :|:.:.||:|.:.|.:...:..:......:.....|.|..:.||.........|....|.
Mouse   383 SGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVDSHI 447

  Fly   464 ------CSASCHCDYVHYAPVCSADNITFISACHAGC-SERTKDALGRTIYTGCECLGSSSLNSE 521
                  |::.|.||...:.|||..:.:|:||.|.||| |.|....|....:..|.|:..|.....
Mouse   448 DVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNIEFYDCSCVSGSGFQKG 512

  Fly   522 PESQFAVDGTCPVD-CFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAA 585
            ..|  |..|.||.| |..::..::.....:....|...::.:|:.:|.:.|:.|:..:|..|:..
Mouse   513 NHS--ARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVV 575

  Fly   586 SLLGFIPSPIFFGWLIDNYCLVWGKT-CSNKGNCWLYDTK--SMRY-ALNLSAAFFIFLGGFLNI 646
            ..||.|.:|:::|.|||..|:.|..| |..:|.|.||:::  .|.| .|:::....|.|   |.:
Mouse   576 RTLGGILAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTPILL---LYV 637

  Fly   647 AVWYHAK-NLKIFDEEESSPKDSLKNKEVE---MKTIDSNPE 684
            |:.|..| .:|..|           ||.:|   ..|.:.|||
Mouse   638 ALIYVMKRKMKRND-----------NKILENGRKFTDEGNPE 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	155/604 (26%)
		MFS	69..>425	CDD:119392	99/385 (26%)
		KAZAL_SLC21	462..514	CDD:238650	20/63 (32%)
Slco1b2	NP_065241.1	MFS	26..557	CDD:421695	137/557 (25%)
Slco1b2	NP_065241.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..689		4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820