Protein Alignment Oatp58Da and SLCO1B3

DIOPT Version :10

• Sequence 1: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_062818.1
• Gene: SLCO1B3 / 28234
• HGNCID: 10961
• Length: 702
• Species: Homo sapiens
• Alignment Length: 708
• Identity: 190/708 - (26%)
• Similarity: 326/708 - (46%)
• Gaps: 102/708 - (14%)

  Fly    27 DKERESAPENETEGEDGGKDTYC-GFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTFAYFNGTI 90
            :|..|||...:.      |...| ||.:|       .|......|...|.|.:|.:       :|
Human     8 NKTAESASSEKK------KTRRCNGFKMF-------LAALSFSYIAKALGGIIMKI-------SI 52

  Fly    91 TTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFL 155
            |.:|:|:.|.:.::|:|....:|..:|....:.|:....|||:.:|||.|.:....:|||..||.
Human    53 TQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFF 117

  Fly   156 YG----AGEDALQLTREFGQ------VNETL----TNQERDKKLCQPTAGGCVQEEVGLWVPQVF 206
            .|    :.|..:..:.....      :|:||    |:.|..:|.|...:|.      .:|   ::
Human   118 MGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGS------HMW---IY 173

  Fly   207 LFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPT 271
            :|...::.|:|:.....|||:|:||...:..:...|.....:.|:||.||::|.::..::|::..
Human   174 VFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIG 238

  Fly   272 LEPL----IGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARK-RRLQLK------QD 325
            ...|    |..:|.||:||||||:||....:::|:|..|..||.....:| |::.|.      .|
Human   239 YVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTND 303

  Fly   326 ERKQSLPLNE------RSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYR 384
            :|.|:..|..      :::....:::|.:..|.:||...:.::|....::..:.:..||:|.||.
Human   304 DRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYG 368

  Fly   385 QSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGS 449
            |||:.|....|.:.:...|.|:.:.|::|.|:|.|...:|.::.:...::....|.|..:.||..
Human   369 QSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESK 433

  Fly   450 DRLNTLTTLSAGNS-----------CSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDALG 503
            .......|....||           |::.|:||...:.|||..:.||::|.|.|||    |.:.|
Human   434 SVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGC----KSSSG 494

  Fly   504 ---RTIYTGCECLGSSSLNSEPESQFAVDGTCPVD--CFNEFLIFLGVMCFLKLVGASSKSTNLL 563
               .|::..|.|:..:.|.:...|  |..|.||.|  |..:|.|::.:.....|..|:..:|.:|
Human   495 IKKHTVFYNCSCVEVTGLQNRNYS--AHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFIL 557

  Fly   564 LALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWG-KTCSNKGNCWLYDTKSMR 627
            |.::.:.|:.|..|:|..||....||.|.:||:||.|||..|:.|. .:|..:|.|.:|
Human   558 LTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIY------ 616

  Fly   628 YALNLSAAFF--IFLGGFLNIAVWYHAKNLK---IFDEEESSPKDSLKNKEVEMKTID 680
                 ::.||  ::||  |:||:.:.|..|.   ||..::.......|..:.|.|.:|
Human   617 -----NSVFFGRVYLG--LSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMD 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	165/606 (27%)
SLCO1B3	NP_062818.1	MFS	28..561	CDD:475125	145/561 (26%)