Protein Alignment Oatp58Da and SLCO4A1

DIOPT Version :9

• Sequence 1: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: XP_011527094.1
• Gene: SLCO4A1 / 28231
• HGNCID: 10953
• Length: 768
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 178/627 - (28%)
• Similarity: 282/627 - (44%)
• Gaps: 63/627 - (10%)

  Fly    36 NETEGEDGGKDTYCGFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTF-AYFNGTITTLEKRYKI 99
            :|......|:...||:|.|..|.:|...|....:.....|..:..||. .:.|..||:||:||.:
Human    73 HEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDL 137

  Fly   100 PTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQ 164
            .:..||:|:...||:..|....:.|:.|..|:|||:|.|:|.:....|:.:..||..|..|..|
Human   138 HSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVEL- 201

  Fly   165 LTREFGQVNETLTNQERDKKLCQPTAGG-CVQEEVGLWVPQVFLFAAQLISGVGQALFYTLGIAY 228
                           :...:.|....|. |.....||...|:.....|.:.|||....||||:.|
Human   202 ---------------DAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTY 251

  Fly   229 MDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPLIGQEDPRWLGAWWLGWLV 293
            :|:|...:.:|..:::.....:||||.||.:....|.:|.|......:..|.|.|:||||:|:|.
Human   252 LDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLG 316

  Fly   294 LAAITLVSAILLFMFPKQLPSARKRRL-------QLKQDERKQSLPLNERSLADMMKTVKKLS-- 349
            ..|....:|:.:..:|:|||.:::..:       |||...|      .|.|..|..||::.|.
Human   317 SGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSR------GEASNPDFGKTIRDLPLS 375

  Fly   350 -----KNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILIS 409
                 ||..::...:|.............|:||::|:|:..||:.|....|.:.:.....|..:.
Human   376 IWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLG 440

  Fly   410 GYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGSDRLNTLTTLSAGNS----------- 463
            |:.::|.:....|:..:......|::.|||.: ::.|.......  .|.|.|.|
Human   441 GFFVNKLRLRGSAVIKFCLFCTVVSLLGILVF-SLHCPSVPMAG--VTASYGGSLLPEGHLNLTA 502

  Fly   464 -CSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDAL-GRTIYTGCECLGSSSLNSEPESQF 526
             |:|:|.|...||:|||.:|.:.:.|.|||||...|:..: |:.:|..|.|:..   |.......
Human   503 PCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQ---NLSSGFGH 564

  Fly   527 AVDGTCPVDCFNE--FLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLG 589
            |..|.|...|..:  .|:|:.|:.|...:   |....|...|||:...:::||||:..:...:||
Human   565 ATAGKCTSTCQRKPLLLVFIFVVIFFTFL---SSIPALTATLRCVRDPQRSFALGIQWIVVRILG 626

  Fly   590 FIPSPIFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSM-RYAL 630
            .||.||.|||:||..||:|...|..:|:|.:|...:| ||.|
Human   627 GIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYIL 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	165/589 (28%)
		MFS	69..>425	CDD:119392	99/371 (27%)
		KAZAL_SLC21	462..514	CDD:238650	22/64 (34%)
SLCO4A1	XP_011527094.1	OATP	106..663	CDD:281175	165/587 (28%)
		MFS	106..>489	CDD:119392	106/407 (26%)
		KAZAL_SLC21	500..555	CDD:238650	21/54 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4629
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760