DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Da and F47E1.4

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_509532.1	Gene:	F47E1.4 / 181146	WormBaseID:	WBGene00018568	Length:	728	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	180/752 - (23%)
Similarity:	308/752 - (40%)	Gaps:	163/752 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 MQRFATEHMYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILG 123
            |||.   :::::|:.:...:.::..:|....:.::|:::::.:.:||::....:...:....|:.
Worm     1 MQRI---YIFIVLFVVVFFLESIGASYIYTALQSIERQFQMSSGISGLLVSATECGYIPCVVIMS 62

  Fly   124 YYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFL--------------------------------- 155
            |:....:|.||:|.|:|.:....|:..:.:||
Worm    63 YFGSKGNRSRWIGGGVLLMSITYLMLGTPNFLFPTRQQKTNGLNISESLRPTPSQLLPNSTLKDL 127

  Fly   156 --YGAGED---------ALQLTRE---------------------FG------------------ 170
              |...||         .|.||.:                     ||
Worm   128 LSYPLMEDQLPSSTYQFLLNLTDDKTPIEQTQTEPTEQGSNPNVTFGIDGYLMKGILIEADNLVK 192

  Fly   171 ------------------QVNETLTN-QERDKKLCQP-TAGG--------------CVQEEVGLW 201
                              :||.::.: |:...|...| |..|              |......:|
Worm   193 NNYSQNSIKQLLSMFIHRRVNRSIDDIQKMKTKAVVPFTVCGKLTNFLRASIENSKCRAGSSNIW 257

  Fly   202 VPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRL 266
             |.:..|.:....|||:.:.:.|||..:|||..|...|........:|:|||..||.:.:...:.
Worm   258 -PFLVFFVSLFFLGVGRTIPWNLGIPLLDDNIKKKHLPMYFGAIASIRVLGPICGYLIGSFSNQF 321

  Fly   267 YIEPTLEPLIG--QEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARKRRLQL------K 323
            |.  ||:...|  ..:..|:||||||:|::.|:::..::|||.||:    .:...|||      |
Worm   322 YY--TLQAPSGLTPVNQGWIGAWWLGFLLIGALSMFPSLLLFFFPQ----GKNSTLQLREIRENK 380

  Fly   324 QDERKQSLPLNERSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQY--RQS 386
            .....:|.|: :..:.:.:.:.|.:...|::....:..:...|.:..|.:|.|||:|||:  .|.
Worm   381 NGRASESKPI-KMKIKEFVISCKSVLGTKIFTGCLLGRVCDIFAFKGYVVFLPKYLETQFGIPQY 444

  Fly   387 AAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCE---- 447
            .....|:...| .|| ..||.:.|::..|::.:.|..|....||..:.:......:.|||.
Worm   445 LVHRYMSMFGV-FGF-GLGIALGGFITKKFRLTGRQTALLMMIVSVLNITVYSSKIFIGCNLIVN 507

  Fly   448 ----GSDRLNTLTTLSAGNSCSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDALGRTI-Y 507
                .|..||...|    |.|::.|.|:..|..||||||...:.|.|||||.|.|:......| :
Worm   508 SIGLNSRELNYNFT----NECNSQCSCENAHLYPVCSADGTAYFSPCHAGCREATQFGSDPVIGF 568

  Fly   508 TGCECLGSSSLNSEPESQFAVDGTCPVDCFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPD 572
            ..|||:         ||.......|...|....::||..:.....|...:...::|:.||.:...
Worm   569 ASCECV---------ESGVVSKSFCQNKCQFSSILFLATVLLGSFVAGVAVVPDMLILLRSVDVG 624

  Fly   573 EKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKTCSN-KGNCWLYDTKSMRYALNLSAAF 636
            .::.::||..||.||.|.:||.|.:|.:||..|.||.|||:. .|:|.:||:..:|..::|....
Worm   625 SRSLSMGLQGMAISLFGTLPSSIIWGLVIDTACRVWDKTCNGANGSCSIYDSDHLRIWMHLLYVG 689

  Fly   637 FIFLGGFLNIAVWYHAKNLKIFDEEESSPKDSLKNKE 673
            ..|:....:|.||.:|.||||.|:..:...::|.|.:
Worm   690 VRFISLLSDIYVWKNAGNLKIMDDPVADNIEALSNPD 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	163/695 (23%)
		MFS	69..>425	CDD:119392	97/482 (20%)
		KAZAL_SLC21	462..514	CDD:238650	23/52 (44%)
F47E1.4	NP_509532.1	oat	95..707	CDD:273279	154/634 (24%)
F47E1.4	NP_509532.1	KAZAL_SLC21	520..575	CDD:238650	24/67 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28658
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.620