DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Da and F47E1.2

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_509531.1	Gene:	F47E1.2 / 181145	WormBaseID:	WBGene00018566	Length:	744	Species:	Caenorhabditis elegans

Alignment Length:	767	Identity:	192/767 - (25%)
Similarity:	315/767 - (41%)	Gaps:	180/767 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EHMYVILYGLAGCVMTMTF---AYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYA 126
            |.:|:.| ||...|..:..   :|.|..:..:|:::::.::.||.:...:|...:.....:.::.
Worm     2 ERIYIFL-GLFSFVFFLEAIGGSYINSAVQNIERQFQMSSRTSGFMISASDFGYIPCVVFIAHFG 65

  Fly   127 GHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAG-------EDALQLTREFGQV--NET------- 175
            ...:|.||:|.|.:.:....|:.:|.:||:..|       |.:.:|....||:  |.|
Worm    66 SKGNRARWIGAGAILVSITYLMLASPNFLFPQGHHDINTTEVSAKLKPTAGQLASNSTLKQLLSY 130

  Fly   176 --------------LTNQE-------------RDKKLCQPTAG---------------------- 191
                          |.|.|             |..|:.|..:|
Worm   131 QLIRDRMPHDTYMSLINLEDDTTPIEEYQPIGRPPKIGQGQSGNSTYTIDGWLFNEALVAAENLI 195

  Fly   192 ------GCVQEEVGLWV------------------------------------------------ 202
                  ..::..:.|::
Worm   196 ANNTSQNTLRSSLSLFIHRRTNTSTKDIQKIRISAAAPFTFCGKLTNSLRAVIKDSKCKEQTSNS 260

  Fly   203 -PQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRL 266
             |.:..|.:.|:.|:|:.:.::||:..:|||..|...||.....:.:|:|||..||.:.:.|.:.
Worm   261 YPFLVFFFSLLLLGIGRTVPWSLGVPLLDDNIKKKSLPAYFGAISSIRVLGPICGYMIGSFCNKF 325

  Fly   267 YIEPTLEPLIG--QEDPRWLGAWWLGWLVLAAITLVSAILLFMFPK---------QLPSARKRRL 320
            |.  ||.|..|  ..||.|:||||:|:|.:.:|.|..:.:||.||:         ||....|.:|
Worm   326 YY--TLNPPNGLTPADPTWIGAWWMGFLFIGSIALFPSTMLFFFPQGKEGDGSAVQLRDVHKEKL 388

  Fly   321 QLKQDERKQSLPLNERSLADMMKTVKKLSKNKVY---VYNTMASILYFFGYMVYWIFTPKYIET- 381
            :...||.:..    ...|.|..|:.||:...|:|   |...:..:|.|.||:|   |.|||:|.
Worm   389 KKSVDEDRTI----TMKLKDFAKSCKKVLSTKIYMGSVLGRVCDVLAFKGYIV---FLPKYLENH 446

  Fly   382 ----QYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYV 442
                ||.....||...    ..|| ..|:...|||..|.|.:.|..|.:..::..:.|......:
Worm   447 FGIPQYLVHRYMAMFG----VFGF-GLGVATGGYVTKKLKLNGRRAAMFVMLMSTLNVCLYSGKI 506

  Fly   443 AIGCE------GSDRLNTLTTLSAGNSCSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDA 501
            .||||      ||:  |..|..:....|::.|.|:.....|||......:.|.|||||.|..:..
Worm   507 FIGCESIVNSIGSN--NRQTNYNFTRECNSQCSCENARLYPVCDQTGFAYFSPCHAGCREAMQYG 569

  Fly   502 LGRTI-YTGCECLGSSSLNSEPESQFAVDGTCPVDCFNEFLIFLGVM--CFLKLVGASSKSTNLL 563
            ....: :|.|:|.....:     |:...:.||..   :..:.||.|:  .|:..:|....   :|
Worm   570 SDPVLDFTSCQCAPGGVV-----SKKFCENTCKT---SSVIFFLTVLPGSFVAGLGVVPA---ML 623

  Fly   564 LALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKTCSN-KGNCWLYDTKSMR 627
            :.||.:||:.::.:|||..||.||.|.:||||.:|.:||..||||.|.|:. :|:|.:|....:|
Worm   624 ILLRSVPPETRSLSLGLQGMAVSLFGTLPSPILWGLVIDAACLVWDKACNGARGSCSIYHPDRLR 688

  Fly   628 YALNLSAAFFIFLGGFLNIAVWYHAKNLKIFDEEESSPKDSLKNKEVEMKTI 679
            ..::|.......:....::.||.|||||.|.||..|..||:::...::|:.:
Worm   689 VWMHLLYVVIRTVALITDVYVWKHAKNLNIMDEPVSEEKDNIRRNSIKMQAV 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	175/710 (25%)
		MFS	69..>425	CDD:119392	111/497 (22%)
		KAZAL_SLC21	462..514	CDD:238650	16/52 (31%)
F47E1.2	NP_509531.1	MFS	8..>92	CDD:119392	17/84 (20%)
		oat	95..715	CDD:273279	161/646 (25%)
		MFS	<274..>503	CDD:304372	76/242 (31%)
		KAZAL_SLC21	528..583	CDD:238650	16/54 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650