DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and Slco4a1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_598292.2	Gene:	Slco4a1 / 171144	RGDID:	620228	Length:	723	Species:	Rattus norvegicus

Alignment Length:	685	Identity:	189/685 - (27%)
Similarity:	312/685 - (45%)	Gaps:	68/685 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PFIEKPFAISDKERESAPENETEG-EDGGKDTYCGFWIFKGPSMQRFATEHMYVILYGLAGCVMT 80
            |.:||        |.|....|.:. ..|.:.|.||:..|....:|.|.|...::.....|..:..
  Rat    60 PQVEK--------RSSQAAREVQYLSSGPQSTLCGWQSFTPKCLQVFNTPKGFLFFLCAASFLQG 116

  Fly    81 MTF-AYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVA 144
            ||. .:.|..||::|:|:.:.:..||:|:...||:..|....:.|:.|:.|:|||:|.|.|.:..
  Rat   117 MTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGI 181

  Fly   145 FCLLTSSLHFLYGAGEDALQLTREFGQVNET---LTNQERDKKLCQPTAGGCVQEEVGLWVPQVF 206
            ..|:.:..||.  ||...:::..| |...||   ||||.:.:         |.....||...::.
  Rat   182 GSLVFALPHFT--AGRYEVEIDDE-GLGTETGTCLTNQSQVE---------CKDRASGLSSYRLI 234

  Fly   207 LFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPT 271
            ....||:.|||....||||:.|:|:|...:.:|..:::.....:||||.||.:....|.:|.|..
  Rat   235 FMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVG 299

  Fly   272 LEPLIGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARK-------RRLQLKQDERKQ 329
            ....:..:.|.|:||||:|:|.......:.||.:..:|:|||.:::       ...|||...|..
  Rat   300 QRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRDN 364

  Fly   330 SLPLNERSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMAT 394
              |...:::.|:..:|..|.:|..::...:|.............|.||:.|.|:..||:.|....
  Rat   365 --PAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLF 427

  Fly   395 GTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCY--------------VAIG 445
            |.:.:.....|.|:.|::::|:|.....:..:..   |.|:..:|.:              |..|
  Rat   428 GYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCL---FCTLTSLLAFFVFLMHCPNVHMAGVTTG 489

  Fly   446 CEGSDRLNTLTTLSAGNSCSASCHCDYVHYAPVCSADNITFISACHAGCSE-RTKDALGRTIYTG 509
            ..||  |.....|....:|:|...|...||:|:|.:|...:.|.|:|||.| ......|:.:|.|
  Rat   490 YVGS--LLPKGQLDLKAACNALYCCQPRHYSPLCGSDGTMYYSPCYAGCPEGAVTGPGGQKVYRG 552

  Fly   510 CECL---GSSSLNSEPESQFAVDGTCPVDCFNEFLIFLGVMCFLKLVGASSKSTNLLLA-LRCMP 570
            |.|:   .||...:      |..|.|...|.::.|:.  |:.|:.::.....|...|.| |||:.
  Rat   553 CSCILEKASSGWGN------ATAGKCASTCQSKPLLL--VLVFVVIIFTFLSSIPALTATLRCVC 609

  Fly   571 PDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSMRYALNLSAA 635
            ..:::||||:..:....||.||.||.|||:||..||:|...|.::|:|::|..::|...|.::..
  Rat   610 DRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYKNEAMSRYLLIAGL 674

  Fly   636 FFIFLGGFLNIAVWYHAKNLKIFDE--EESSPKDS 668
            .|..||....:|.::..|:..:..:  |.|.|..|
  Rat   675 TFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQS 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	164/588 (28%)
		MFS	69..>425	CDD:119392	99/366 (27%)
		KAZAL_SLC21	462..514	CDD:238650	19/55 (35%)
Slco4a1	NP_598292.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..57
		OATP	103..665	CDD:281175	164/588 (28%)
		MFS	105..>340	CDD:119392	72/246 (29%)
		KAZAL_SLC21	502..556	CDD:238650	18/53 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910