DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and Slco6b1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_596903.1	Gene:	Slco6b1 / 170925	RGDID:	620278	Length:	748	Species:	Rattus norvegicus

Alignment Length:	724	Identity:	173/724 - (23%)
Similarity:	293/724 - (40%)	Gaps:	104/724 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EERGKVDLEKSETLPF-IEKPFAISDKERESAPENETEGEDGGK-----DTYCGFWIFKGPSMQR 61
            ||....|.|.....|: |....|:||........:||..:...|     |...|......||:||
  Rat    74 EEWTDDDQEHIRVFPYQIRLSAAMSDVTGLQNANSETSSQLSDKIPTDLDGPFGLGSLVVPSLQR 138

  Fly    62 FATEHMYVILYGLAGCVMTM----TFAYFNGTITTLEKRYKI--PTKVSGIISVGNDISTMLTAA 120
            |...:.::|.:    |::|:    .|...:.:|...|:.:.:  |.|:  :::...|:|::|...
  Rat   139 FNNINFFLISF----CILTLAQGIVFGLTDLSIGNFERDFYLSHPEKI--LLTTAYDLSSLLVVI 197

  Fly   121 ILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGE--DALQLTREFGQVNETLTNQERDK 183
            |:.:|.|...|.||:              ::..||.|.|.  .||...:     .|.:...|...
  Rat   198 IVAHYGGRGRRSRWV--------------ATAAFLVGLGSIIGALPYLK-----YEVIHPVEETG 243

  Fly   184 KLC----QPTAGGCVQEEVGLWVPQVFLFAAQLI--SGVGQAL-------FYTLGIAYMDDNTSK 235
            :||    |.|...|         .::..|.:::|  |.:||..       .|.||:.|:.||.|.
  Rat   244 ELCKDEEQRTMPNC---------EKIIPFKSEIIYLSVIGQCFQGFASMPMYVLGMTYIYDNISS 299

  Fly   236 AKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPLIGQEDPRWLGAWWLGWLVLAAITLV 300
            ......|.::....:||..:||::.:..||..:..:.|..:......|...|:||:.....:...
  Rat   300 YLAGIYLGIADASFVLGYGLGYAVGSPNLRPSLNHSSEEKVNDNFLWWQFNWFLGFFSATLLAWF 364

  Fly   301 SAILLFMFPKQLPSARKRRLQLKQDE----RKQSLPLNERSLADMMKTVKKLSKNKVYVYNTMAS 361
            :...|..||.:||.:.|.|: .|::|    :|........|..|:::.:..|.||.:.:..:|..
  Rat   365 TVFPLLCFPHRLPGSNKLRV-WKENEPFFYKKYKDLKYGYSFQDLLRALWYLVKNPLLMCYSMCK 428

  Fly   362 ILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAW 426
            .......:....|.|||:|.|:..|.:.|.:.||.:.:...|.|..:.|:::||.|.|.:..
  Rat   429 ATESLALIGATEFLPKYLENQFLLSPSSAALLTGIILIPGGAIGNFLGGFIVSKMKMSCKTQ--- 490

  Fly   427 NAIVDFVTVAGILCYVA------IGC------------EGSDRLNTLTTLSAGNSCSASCHCDYV 473
               :.|:||..::..:.      :.|            |||..|..||.     .|:|.|.|...
  Rat   491 ---MRFITVTSVISLLLFVLNAFVKCERVKFAGINSDYEGSGTLGNLTA-----PCNAHCGCTSH 547

  Fly   474 HYAPVCSADNITFISACHAGCSERTKDALGRTIYTGCECL--GSSSLNSEPESQFAVDGTCPVDC 536
            .|..:|..|.|.:.|.|.|||....:....:|:| .|.|:  |.::.:||.:...|..|.|...|
  Rat   548 TYYAICGRDEIEYFSPCFAGCLNSKELNYEKTLY-NCSCIKHGLANADSENDPIDAFLGKCNTKC 611

  Fly   537 FNEFLIFLGVMCFLKLVGASSKSTNL-LLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWL 600
            :...|.|  ...|..:|.:||.|..: |:.||.:|....:..|.:......:.|.||.|:.|...
  Rat   612 YALPLFF--AFFFSSIVFSSSASIPITLIILRTLPTSLHSLGLAVTYTILRIFGSIPGPLLFRIA 674

  Fly   601 IDNYCLVWG-KTCSNKGNCWLYDT-KSMRYALNLSAAFFIFLGGFLNIAVWYHAKNLKIFDEEES 663
            ..:.|..|. ..|..:|:||:|:. |.|...:.|..:..: :...|::........|::..|...
  Rat   675 SSSSCSYWDINKCGLRGHCWIYNKFKMMSILMGLCISCKL-ISTLLSLLALLKYNVLRVGSEGVK 738

  Fly   664 SPKDSLKNK 672
            ..|:|...|
  Rat   739 KTKESKTRK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	146/606 (24%)
		MFS	69..>425	CDD:119392	87/380 (23%)
		KAZAL_SLC21	462..514	CDD:238650	17/53 (32%)
Slco6b1	NP_596903.1	OATP	144..701	CDD:281175	145/605 (24%)
		MFS	146..>510	CDD:119392	90/404 (22%)
		KAZAL_SLC21	534..587	CDD:238650	19/58 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810