Protein Alignment Oatp58Da and Slco1a4

DIOPT Version :10

• Sequence 1: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_571981.1
• Gene: Slco1a4 / 170698
• RGDID: 621389
• Length: 661
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 191/671 - (28%)
• Similarity: 305/671 - (45%)
• Gaps: 79/671 - (11%)

  Fly    56 GPSMQRFATE--------HMYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIISVGND 112
            |.|.:|.||.        .|:::....|....:::..|.|..:|.:|:::.|||.:.|:|:...:
  Rat     2 GKSEKRVATHGVRCFAKIKMFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSIVGLINGSFE 66

  Fly   113 ISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQLTREFGQVNETLT 177
            |..:|....:.|:....|||..:|:|...:...|.|.|..|||.|..|....|.......|....
  Rat    67 IGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISLPHFLMGQYEYETILPTSNVSSNSFFC 131

  Fly   178 NQERDKKLCQPT--AGGCVQEEVGL-WVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTP 239
            .:.|.:.| .||  ...||:|...| |   :::....:|.|:|:.....|||:|::|......:|
  Rat   132 VENRSQTL-NPTQDPSECVKEMKSLMW---IYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSP 192

  Fly   240 AMLSMSTFLRMLGPAIGYSLAAVCLRLYIE----PTLEPLIGQEDPRWLGAWWLGWLVLAAITLV 300
            ..:.:......:||.||..||:.|..:|::    .|.:..|...|.||:||||:|:||.|.:.::
  Rat   193 LYIGILETGMTIGPLIGLLLASSCANIYVDIESVNTDDLTITPTDTRWVGAWWIGFLVCAGVNIL 257

  Fly   301 SAILLFMFPKQLP------------SARKRRLQLKQDERKQSLPLNERSLADMMKTVKKLSKNKV 353
            ::...|.|||.||            :|::::.:.|..|.|:.:      ..|....:|.||.|.:
  Rat   258 TSFPFFFFPKTLPKEGLQENVDGTENAKEKKHRKKAKEEKRGI------TKDFFVFMKSLSCNPI 316

  Fly   354 YVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYK- 417
            |:...:.|:|.|..::..:.|.|||:|.||.:|.|......|...|.....|.||.|.::.|:|
  Rat   317 YMLFILISVLQFNAFINSFTFMPKYLEQQYGKSTAEVVFLMGLYMLPPICLGYLIGGLIMKKFKV 381

  Fly   418 --PSARAMAAWNAIVDFVTVAGILCYVAIGCEGSDRLNTLTTLSAG------------NSCSASC 468
              ..|..:|.|..:.::  :...|.|| :.|:... :..|||...|            ..|:..|
  Rat   382 TVKKAAHLAFWLCLSEY--LLSFLSYV-MTCDNFP-VAGLTTSYEGVQHQLYVENKVLADCNTRC 442

  Fly   469 HCDYVHYAPVCSADNITFISACHAGCSERTKDALGRTIYTGCECLGSSSLNSEPESQFAVDGTC- 532
            :|....:.|||..:.:.::|||.||| |::.......::..|.|:.||..:|      ||.|.|
  Rat   443 NCSTNTWDPVCGDNGLAYMSACLAGC-EKSVGTGTNMVFQNCSCIQSSGNSS------AVLGLCN 500

  Fly   533 --PVDCFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSPI 595
              | ||.|:...||.:..|...:.:.:.....::.|||:..:||:..:||.:....:|..||:||
  Rat   501 KGP-DCANKLQYFLIIAIFGCFIYSLAGIPGYMVLLRCIKSEEKSLGVGLHAFCIRILAGIPAPI 564

  Fly   596 FFGWLIDNYCLVWGK-TCSNKGNCWLYDTKSM-RYALNLSAAFFIFLGGFLNIAVWYHAKNLKIF 658
            :||.|||..||.||. .|...|.|.:||..|. |..|.|.||    |.|...:..::..:..:.|
  Rat   565 YFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRLYLGLPAA----LRGASFVPAFFILRLTRTF 625

  Fly   659 DEEESSPKD--SLKNKEVEMK 677
                ..|.|  |.|....|||
  Rat   626 ----QFPGDIESSKTDHAEMK 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	170/596 (29%)
Slco1a4	NP_571981.1	oat	1..623	CDD:273279	183/646 (28%)