DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and Slco2b1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_006229783.1	Gene:	Slco2b1 / 140860	RGDID:	621391	Length:	693	Species:	Rattus norvegicus

Alignment Length:	733	Identity:	169/733 - (23%)
Similarity:	316/733 - (43%)	Gaps:	134/733 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ERESAPENETEGEDGGKDTYCGFWIFKGPSMQ------------RFATEHMYVILYGLAGCVMTM 81
            |....|:..|:...|.:|.:     .:..||:            .|.....:|:.:.:......|
  Rat     7 EGPQMPDRSTKATMGAEDIH-----ERKVSMEPRDSHQDAQPRGMFQNIKFFVLCHSILQLAQLM 66

  Fly    82 TFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFC 146
            ...|...:|:|:|||:.:.::.||:::..|::..:.....:.|:....||||.:|.|.:.:....
  Rat    67 ISGYLKSSISTVEKRFGLSSQTSGLLAAFNEVGNISLILFVSYFGSRVHRPRMIGCGAILVAVAG 131

  Fly   147 LLTSSLHFL-------YGAGEDALQLTREFGQVNETLTNQERDKKLCQPTA---------GGCVQ 195
            ||.:..||:       :.:.||               .:|:.:..||.||.         ..|..
  Rat   132 LLMALPHFISEPYRYDHSSPED---------------RSQDFEASLCLPTTMAPASALSNDSCSS 181

  Fly   196 EE-------VGLWVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGP 253
            ..       ||:      :|.||.:.|:|.......||:|:||....:.:|..|.:...:.|:||
  Rat   182 RTETKHLTMVGI------MFTAQTLLGIGGVPIQPFGISYIDDFAHHSNSPLYLGILFAITMMGP 240

  Fly   254 AIGYSLAAVCLRLYIEPTLEPLIG----QEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPS 314
            .:.|.|.::.||||::....|..|    .:||||:||||||:|:.|.:.:::|...|.||:::|.
  Rat   241 GLAYGLGSLMLRLYVDIDRMPEGGINLTTKDPRWVGAWWLGFLISAGLVVLAASPYFFFPREMPK 305

  Fly   315 ARKRRLQLKQ--------------DERKQSLPLNERS----LADMMKTVK----------KLSKN 351
             .|..|..:|              :...|..||.:::    :|..:..|:          :..::
  Rat   306 -EKYELHFRQKVLAGGASIGSKGEELSSQHEPLKKQAGLPQIAPDLTVVQFIKVFPRVLLRTLRH 369

  Fly   352 KVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKY 416
            .:::...::.:...........|.||::|.|:..:|:.|.:..|.:.:..:..||::.|.::.:.
  Rat   370 PIFLLVVLSQVCTSSMVAGTATFLPKFLERQFSITASFANLLLGCLTIPLAIVGIVVGGVLVKRL 434

  Fly   417 KPSARAMAAWNAIVDFVTVAGILCYVA------IGCEGSDRLNTLTTLSA--GNS----CSASCH 469
            ..|....:|      ...:..:||.:.      |||...........|.|  |.|    ||..|.
  Rat   435 HLSPMQCSA------LCLLGSLLCLLLSLPLFFIGCSTHHIAGITQDLGAQPGPSLFPGCSEPCS 493

  Fly   470 CDYVHYAPVC-SADNITFISACHAGCSER-TKDALGRT--IYTGCECL-GSSSLNSEPESQFAVD 529
            |....:.||| ::..:.:.:.|||||:.| .::||.::  .||.|.|: |:.::::
  Rat   494 CQSDDFNPVCDTSAYVEYTTPCHAGCTGRVVQEALDKSQVFYTNCSCVAGNGTISA--------- 549

  Fly   530 GTCPVDCFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSP 594
            |:|...|....|.|:.::.....|.:.:.:.:.:|.||.:..::||.|:|:..|...:|.::|||
  Rat   550 GSCESACSRLVLPFILLISLGAAVASITHTPSFMLILRGVKKEDKTLAVGMQFMLLRVLAWMPSP 614

  Fly   595 IFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSMRYALNLSAAFFIFLGGFLNIAVWYHAKNLKIFD 659
            :..|..||..|:.|..||..:..|..||...:|... :...||...|..:..|:     .|.|..
  Rat   615 VIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRNRF-IGLQFFFKSGSLVCFAL-----VLAILR 673

  Fly   660 EE--ESSPKDSLKNKEVE 675
            ::  |:|.|.::|:.:::
  Rat   674 QQSREASTKATVKSSDLQ 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	150/630 (24%)
		MFS	69..>425	CDD:119392	92/410 (22%)
		KAZAL_SLC21	462..514	CDD:238650	20/60 (33%)
Slco2b1	XP_006229783.1	OATP	52..646	CDD:281175	150/630 (24%)
		MFS	58..>301	CDD:119392	69/263 (26%)
		KAZAL_SLC21	484..541	CDD:238650	18/56 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750