Protein Alignment Oatp58Da and SLCO6A1

DIOPT Version :10

• Sequence 1: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_775759.3
• Gene: SLCO6A1 / 133482
• HGNCID: 23613
• Length: 719
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 159/688 - (23%)
• Similarity: 286/688 - (41%)
• Gaps: 76/688 - (11%)

  Fly    28 KERESAPENETE--GE-DGGKDTYCGFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTFAYFNGT 89
            ::|:.|..:.::  || |...:..||.........:.......::|.|.:......:.|...:.:
Human    65 RKRKKAKSSVSKKPGEVDDSLEQPCGLGCLVSTCCECCNNIRCFMIFYCILLICQGVVFGLIDVS 129

  Fly    90 ITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHF 154
            |...:|.|::.|.....:....|||:.|.|..:.:| |.|.:..|            .:.||  |
Human   130 IGDFQKEYQLKTIEKLALEKSYDISSGLVAIFIAFY-GDRKKVIW------------FVASS--F 179

  Fly   155 LYGAGEDALQLTREFGQVNETLTNQERDKK-----LCQ--PTAGGCVQEEVGLWVPQV-FLFAAQ 211
            |.|.|    .|...|..:||    :.:..|     :|:  ....||....:......: |....|
Human   180 LIGLG----SLLCAFPSINE----ENKQSKVGIEDICEEIKVVSGCQSSGISFQSKYLSFFILGQ 236

  Fly   212 LISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPT--LEP 274
            .:.|:.....|.|||.::|:|.:.......|.::....|:|.|:||.|.|..:::....|  ...
Human   237 TVQGIAGMPLYILGITFIDENVATHSAGIYLGIAECTSMIGYALGYVLGAPLVKVPENTTSATNT 301

  Fly   275 LIGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLP-----SARKRRLQLKQDERKQSLPLN 334
            .:....|.||..||:.:|..|.:...:.|.|..||..:|     .||||:.....|.|.:.|.|.
Human   302 TVNNGSPEWLWTWWINFLFAAVVAWCTLIPLSCFPNNMPGSTRIKARKRKQLHFFDSRLKDLKLG 366

  Fly   335 ERSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVAL 399
             .::.|:...:..|.||.|.:...::....:...:....|.|.|:|.|:..:..:||...|.|.:
Human   367 -TNIKDLCAALWILMKNPVLICLALSKATEYLVIIGASEFLPIYLENQFILTPTVATTLAGLVLI 430

  Fly   400 GFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGC------------EGSDRL 452
            ...|.|.|:.|.::|..:.|.:|:..:..:...:::..::..:.:.|            :|:.:|
Human   431 PGGALGQLLGGVIVSTLEMSCKALMRFIMVTSVISLILLVFIIFVRCNPVQFAGINEDYDGTGKL 495

  Fly   453 NTLTTLSAGNSCSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDALGRTIYTGCECLGSSS 517
            ..||.     .|:..|.|....|:.:|..|:|.:.|.|.|||: .:|....:.:|..|.|:....
Human   496 GNLTA-----PCNEKCRCSSSIYSSICGRDDIEYFSPCFAGCT-YSKAQNQKKMYYNCSCIKEGL 554

  Fly   518 LNSEPESQF--AVDGTCPVDCFN--EFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDE-KTFA 577
            :.::.|..|  |..|.|...|:.  .|:.|:    |..|:.:......::||:..:.||: ::.|
Human   555 ITADAEGDFIDARPGKCDAKCYKLPLFIAFI----FSTLIFSGFSGVPIVLAMTRVVPDKLRSLA 615

  Fly   578 LGLGSMAASLLGFIPSPIFFGWLIDNYCLVWG-KTCSNKGNCWLYDTKSMRYALNLSAAFFIFLG 641
            ||:..:...:.|.||.|..|....:..|::.. ..|.:.|.||:|:...|.:.| :...|...|.
Human   616 LGVSYVILRIFGTIPGPSIFKMSGETSCILRDVNKCGHTGRCWIYNKTKMAFLL-VGICFLCKLC 679

  Fly   642 G--FLNIAVWYHAKNLKIFDEEESSPKDSLKNKEVEMK 677
            .  |..||.:.:.:.|   :|....|..::||.:|:.|
Human   680 TIIFTTIAFFIYKRRL---NENTDFPDVTVKNPKVKKK 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	138/591 (23%)
SLCO6A1	NP_775759.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		MFS_SLCO6_OATP6	105..605	CDD:340963	122/533 (23%)