DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Da and Slco4a1

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001342147.1	Gene:	Slco4a1 / 108115	MGIID:	1351866	Length:	723	Species:	Mus musculus

Alignment Length:	688	Identity:	191/688 - (27%)
Similarity:	324/688 - (47%)	Gaps:	62/688 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SETLPFIEKPFAISDKERESAPENETE-GEDGGKDTYCGFWIFKGPSMQRFATEHMYVILYGLAG 76
            |.:.|..| |.|   ::|.|....|.: ...|.:::.||:..|....:|.|.|...::.....|.
Mouse    52 SSSQPLFE-PQA---EKRSSQTAREVQYVSSGPQNSLCGWQAFTPKCLQVFNTPKGFLFFLCAAS 112

  Fly    77 CVMTMTF-AYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLL 140
            .:..||. .:.|..||::|:|:.:.:..||:|:...||:..|....:.|:.|:.|:|||:|.|:|
Mouse   113 FLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVL 177

  Fly   141 TIVAFCLLTSSLHFLYGAGEDALQLTREFGQVNETLTNQERDKKLCQPTAGGCVQEEVGLWVPQV 205
            .:....|:.:..||.  ||...:::....| ....||||...:  |:.:|.|.....:      :
Mouse   178 VLGIGSLVFALPHFT--AGRYEVEMDEGLG-TGTCLTNQSHVE--CKDSASGLSNYRL------I 231

  Fly   206 FLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEP 270
            |:. .||:.|||....||||:.|:|:|...:.:|..:::.....:||||.||.:....|.:|.|.
Mouse   232 FML-GQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEV 295

  Fly   271 TLEPLIGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARK-------RRLQLKQDER- 327
            .....:..:.|.|:||||:|:|.......:.||.:..:|:|||.:::       ...|||...|
Mouse   296 GQRTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRG 360

  Fly   328 KQSLPLNERSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATM 392
            ..|.|...:::.|:..::..|.:|..::...:|.............|.||:.|.|:..||:.|..
Mouse   361 AVSNPAFGKTVRDLPLSIWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAAT 425

  Fly   393 ATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCY--------------VA 443
            ..|.:.:.....|.|:.|::::|:|.....:..:..   |.|:..:|.:              |.
Mouse   426 LFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCL---FCTLTSLLAFFVFLMHCPNVHMAGVT 487

  Fly   444 IGCEGSDRLNTLTTLSAGNSCSASCHCDYVHYAPVCSADNITFISACHAGC-SERTKDALGRTIY 507
            .|..||  |.....|....:|:|...|...||:|:|.:|...:.|.|:||| ::...|..|:.:|
Mouse   488 TGYVGS--LLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPADAETDLGGQKVY 550

  Fly   508 TGCECL---GSSSLNSEPESQFAVDGTCPVDCFNEFLIFLGVMCFLKLVGASSKSTNLLLA-LRC 568
            .||.|:   .||...:      |..|.|...|.::  .||.|:.|:.::.....|...|.| |||
Mouse   551 RGCSCILEKASSGWGN------ATAGKCASTCQSK--PFLLVLVFVVIIFTFLSSIPALTATLRC 607

  Fly   569 MPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSM-RYALNL 632
            :...:::||||:..:....||.||.||.|||:||..||:|...|.::|:|::|:.::| ||.| :
Mouse   608 VSDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAMSRYML-I 671

  Fly   633 SAAFFIFLGGFLNIAVWYHAKNLKIFDE--EESSPKDS 668
            :...|..||....:|.::..|:..:..:  |.|.|..|
Mouse   672 AGLTFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQS 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	163/586 (28%)
		MFS	69..>425	CDD:119392	97/364 (27%)
		KAZAL_SLC21	462..514	CDD:238650	19/55 (35%)
Slco4a1	NP_001342147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..64		5/15 (33%)
		OATP	103..665	CDD:308646	163/586 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4629
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.760