DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Da and slco1f2

DIOPT Version :9

Sequence 1:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001121745.2	Gene:	slco1f2 / 100190901	ZFINID:	ZDB-GENE-080305-3	Length:	662	Species:	Danio rerio

Alignment Length:	657	Identity:	190/657 - (28%)
Similarity:	319/657 - (48%)	Gaps:	56/657 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SMQRFATEHMYVILYGLAGCVM--TMTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAA 120
            |..:.....:.:.:..||.|..  :||.:|...|||.:|:|::||:...|||..|.::..||...
Zfish    18 SQTKCCPPRLKIFIAALAFCYFSKSMTASYTKSTITQIERRFEIPSSTVGIIDGGFEMGNMLVIT 82

  Fly   121 ILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGE--DALQLTREFGQVNETLTNQERDK 183
            ::.|.....|||:.:|.|:|.:....||.:|.||:.|..:  .|...|.:.|......|.....:
Zfish    83 LVSYVGAKFHRPKIIGAGVLLMGIGTLLMASPHFIMGRYKYGTAATHTNDAGNFTVISTCSSDSQ 147

  Fly   184 KLCQPTAGGCVQEEV---GLWVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMS 245
            |..|....||.:||.   .||   |.:.....:.|:|:|....||::::||......:...:...
Zfish   148 KTLQQPFSGCRKEEAESSPLW---VIVVLGNTMLGIGEASIIPLGMSFVDDYARPENSAFYIGCL 209

  Fly   246 TFLRMLGPAIGYSLAAVCLRLYIE--------PTLEPLIGQEDPRWLGAWWLGWLVLAAITLVSA 302
            ..::.:||..|:.|.::|..||::        .|:.|    :|.||:||||||::|...:|:::|
Zfish   210 NTIKGIGPIFGFVLGSLCANLYVDIGLVNKESVTITP----QDSRWVGAWWLGYVVSGLLTVLAA 270

  Fly   303 ILLFMFPKQLPSARKRRLQLKQDERKQSLPLNERSLADMMKTVKKLSKNKVYVYNTMASILYFFG 367
            ...:..||.||...:..|.....::.::.|.....:.|...|.|:|..||:|:.....||:.|..
Zfish   271 FPFWFLPKALPENSQISLLDNTPQQHKTTPSLTEIVKDFAPTFKRLLTNKIYILYLAYSIVAFND 335

  Fly   368 YMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDF 432
            :.:...:||||:|.|:.|||:.|....|...:...|.|:.:||.::.::|....|.|..|.:...
Zfish   336 FAILVTYTPKYLEQQFGQSASKANFLIGVTCVPAVALGVFLSGLMMKRFKWGLLASARVNLLTIV 400

  Fly   433 VTVAGILCYVAIGCE------------GSDRLNTLTTLSAGNSCSASCHCDYVHYAPVCSADNIT 485
            .||...:.:.|:.||            ||..:..:|: ....||:|.|.|..:|:.|||..:.:|
Zfish   401 ATVFLTVPFFALSCENLDIAGVTVPYQGSTEVQGVTS-DVLPSCNADCGCPDLHWDPVCGENGVT 464

  Fly   486 FISACHAGCSERTKDALGRTIYTGCECLGSSSLNSEPESQFAVDGTCP--VDCFNEFLIFLGVM- 547
            :||.||||||. |:.|.....:..|.|:.|..|:....|  ||.|.|.  .:|.....::||:.
Zfish   465 YISPCHAGCSS-TQGAGRNKTFHDCGCIQSWGLSVGNSS--AVLGQCSQNPNCNRMMYLYLGLQS 526

  Fly   548 --CFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWG- 609
              .|:..:||....|   ::||.:.|:.|:.::|:..::..:||.||:||:||.|:|:.||.||
Zfish   527 LALFVYSLGAVPLFT---MSLRIVDPELKSLSVGVLLLSIRVLGGIPAPIYFGALVDSSCLKWGQ 588

  Fly   610 -KTCSNKGNCWLYDTKSMRYAL-NLSAAFFIFLGGFLNIA-VWYHAK--NLKIFDEE---ESSPK 666
             |:| .:|.|.:||.::.|:.. .|:....:.....|.|| :|...|  |.|...|:   :..|.
Zfish   589 RKSC-GRGACRIYDIETFRFLFQGLTNCLRVLACSLLWIATIWIKRKIQNDKQISEDMELQRGPS 652

  Fly   667 DSLKNKE 673
            |..::::
Zfish   653 DDPEHED 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	177/592 (30%)
		MFS	69..>425	CDD:119392	106/370 (29%)
		KAZAL_SLC21	462..514	CDD:238650	22/51 (43%)
slco1f2	NP_001121745.2	OATP	29..605	CDD:281175	177/590 (30%)
		MFS	31..>413	CDD:119392	111/388 (29%)
		KAZAL_SLC21	440..492	CDD:238650	22/52 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D434101at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920