DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and ARI3

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_189408.1	Gene:	ARI3 / 822393	AraportID:	AT3G27710	Length:	537	Species:	Arabidopsis thaliana

Alignment Length:	523	Identity:	164/523 - (31%)
Similarity:	242/523 - (46%)	Gaps:	81/523 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDIEM---DMESDNDGEYDDDYDYYNTGEDCDVERLDPKRADPEYFEYECLTVEDIEKLLNER 62
            ||.|..|   |...:.|..|.:| |.|:..| .|::.:...::..:..:.|.|.....|.|:  |
plant     1 MDDDYMMLDDDYGEEEDENYSED-DNYSEAE-VDLQPVTSTKSTSQVIKKESLVAAQKEILV--R 61

  Fly    63 VEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKPPSVAVTDTASTSAAAAS 127
            |.:|   |.:..:.|:.||:.:|||    |||..               ||..........:.|.
plant    62 VMEL---LSVKENQARTLLIYYQWN----VEKLF---------------SVFADQGKDRMFSCAG 104

  Fly   128 AQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYS-LACGHSFCKDCWTIYFETQIFQGI 191
            ..:.         ..|.....::..|.||....|.....: :.|||.||.|||..:|..:|.:|.
plant   105 LTVF---------VPSLVTSKKTMKCDVCMEDDLPSNVMTRMECGHRFCNDCWIGHFTVKINEGE 160

  Fly   192 STQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPG-PNCQIIVQSSE 255
            |.:|.|||..|.....||:|..||: |.:.|:|.:|..:.||:.:..:::||. |:|...::..|
plant   161 SKRILCMAHECKAICDEDVVRKLVS-PELADRYDRFLIESYVEDNNMVKWCPSKPHCGSAIRKIE 224

  Fly   256 ISAKRAICKACHTG--FCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICI 318
             .....:...|..|  |||.|..:.|:|..|.:.|.|..||.|:|||.|:|:.:||.||||...|
plant   225 -DGHDVVEVGCSCGLQFCFSCLSESHSPCSCLMWKLWKKKCEDESETVNWITVNTKLCPKCSKPI 288

  Fly   319 EKNGGCNHMQCFNCKHDFCWMC---LGDWKTHGS-EYYECSRYKDNPNIANESVH--VQAREALK 377
            :|..|||.|.| .|...|||:|   .|...|:.| ..:.|.||||      |.|.  .:|:..|.
plant   289 QKRDGCNLMTC-KCGQHFCWLCGQATGRDHTYTSIAGHSCGRYKD------EKVRQLERAQRDLD 346

  Fly   378 KYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGT-----WIDWQYLFNAAALLAKCRYT 437
            :|.||:.|::.|..|||||    |:||:.|..|.::.|.|     :.::.::.:|...|...|..
plant   347 RYTHYHYRYKAHIDSLKLE----DKLRKSILEKAVSNSETKDQKVFKEYSWVTDAVNRLFISRRI 407

  Fly   438 LQYTYPYAYYM-------------EAGSRKNLFEYQQAQLEAEIENLSWKIERAETTDLGDLENQ 489
            |..:||:|:||             |...:|||||.||.|||..:|.||..:|  |..|..|.|..
plant   408 LSQSYPFAFYMFGEELFKDEMSEKEREIKKNLFEDQQQQLEGNVEKLSKILE--EPFDEYDHEKV 470

  Fly   490 MDI 492
            :::
plant   471 VEM 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	21/53 (40%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	18/64 (28%)
ARI3	NP_189408.1	RING-HC_RBR_TRIAD1_like	121..171	CDD:319537	20/49 (41%)
		RING-HC finger (C3HC4-type)	121..171	CDD:319537	20/49 (41%)
		IBR	190..254	CDD:214763	18/64 (28%)
		IBR	<277..311	CDD:366672	18/34 (53%)
		COG4026	<431..519	CDD:226513	19/45 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	79	1.000	Domainoid score	I3020
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I974
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		mtm1176
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11685
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	10.030