DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and ARI10

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_180735.1	Gene:	ARI10 / 817733	AraportID:	AT2G31760	Length:	514	Species:	Arabidopsis thaliana

Alignment Length:	516	Identity:	157/516 - (30%)
Similarity:	247/516 - (47%)	Gaps:	66/516 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DIEMDMESDNDGEYDDDYDYYNTGEDCDVERLDPKRADPEYFEYECLTVEDIEKLLNERVEKLNT 68
            |.|...|:::||..::.|: ||...|..:  |..|       .|..:..|:|.||..:.:|:::|
plant    10 DNESGEENNSDGGGNESYN-YNAAVDTII--LSEK-------SYVIIKEEEILKLQRDDIERVST 64

  Fly    69 ILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARI-KPPSVAVTDTASTSAAAASAQLLR 132
            ||.::...|.||||.:.|....:.:::..|...:..|..| |.|.|.|..|..
plant    65 ILFLSQVEAIVLLLHYHWCVSKLEDEWFTDEERIRKTVGILKEPVVDVNGTEV------------ 117

  Fly   133 LGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQGIS-TQIG 196
                             ...|.:|..|....:..|::|||.:||.|||.|..|:|..|.. .::.
plant   118 -----------------DIQCGICFESYTRKEIASVSCGHPYCKTCWTGYITTKIEDGPGCLRVK 165

  Fly   197 CMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRA 261
            |....|...|.:|:: ..||....:|||.::..:.||:...::::||.|.|:..|:..|.|....
plant   166 CPEPSCYAVVGQDMI-DEVTEKKDKDKYYRYFLRSYVEDGKKMKWCPSPGCECAVEFGESSGYDV 229

  Fly   262 ICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNH 326
            .| .|...||:.|..|.|:|.||:.:.||:.|..|:||..|:|.|::|.||||...|||:.||||
plant   230 AC-LCSYRFCWNCSEDAHSPVDCETVSKWIFKNQDESENKNWILANSKPCPKCKRPIEKSHGCNH 293

  Fly   327 MQC-FNCKHDFCWMCLGDWKTHGSEYYECSRYKDNPNIANESVHVQAREALKKYLHYYERW-ENH 389
            |.| .:|.|.|||:|   .|:: |::|.|:.|.::   |:.......:..:|:|.|||.|| ||.
plant   294 MTCSASCGHRFCWIC---GKSY-SDHYACNNYVED---ADHDKRTLLQSEIKRYTHYYVRWVENQ 351

  Fly   390 SKSLK----LEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEA 450
            |..||    ||:....:|:|..:    |.....||.|::.:|...:.:||..|::||.|.||::.
plant   352 SSRLKAMSDLEKFQSVQLKQLSD----NQCKPKIDLQFIVDAWLQIIECRRVLKWTYAYGYYLDN 412

  Fly   451 GSRKNLFEYQQAQLEAEIENLSWKIER------AETTDLGDLENQMDIAEKRRTTLLKDFF 505
            .:::.||||.|.:.|..:|.|....|.      .::.|..|..|...:.....|.:.|.:|
plant   413 LAKRPLFEYLQGEAETGLERLHHCAENELKQFFIKSEDPSDTFNAFRMKLTGLTKVTKTYF 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	18/53 (34%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	20/61 (33%)
ARI10	NP_180735.1	RING-HC_RBR_TRIAD1_like	121..171	CDD:319537	17/49 (35%)
		IBR	190..251	CDD:214763	20/61 (33%)
		IBR	<273..312	CDD:396187	22/41 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		mtm1045
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890