DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and ARI7

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_180709.3	Gene:	ARI7 / 817709	AraportID:	AT2G31510	Length:	562	Species:	Arabidopsis thaliana

Alignment Length:	559	Identity:	152/559 - (27%)
Similarity:	252/559 - (45%)	Gaps:	108/559 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDIEM----DMESDNDGEYDDDYDYYNTG-EDCDVERLDPKRADPEYFEYE------------ 48
            |||:.:|    ||||..|       |:|:.| :||:    |....:|:|...|
plant     1 MDSEEDMLDAHDMESGED-------DFYSGGTDDCN----DSDDGEPDYGFVEEDADDSAMIASH 54

  Fly    49 ------C-LTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANAL---- 102
                  | |..|||.:...:.:|:::.:|.||...|.:||....|:...|.:::..|...:
plant    55 RSQKNFCVLREEDIRRHQMDNIERVSVVLSITEVEASILLRHFHWSVGRVHDEWFADEERVRKTV 119

  Fly   103 -LVTARIKPPSVAVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFY 166
             ::.:.:.|||   .|:..|                               |.:|..|...:|..
plant   120 GILESHVVPPS---DDSELT-------------------------------CGICFDSYPPEKIA 150

  Fly   167 SLACGHSFCKDCWTIYFETQIFQGIS-TQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFK 230
            |::|||.||..|||.|..|.|..|.. ..:.|....|...|..|:|..|.:.. .::||.::..:
plant   151 SVSCGHPFCTTCWTGYISTTINDGPGCLMLRCPDPSCLAAVGHDMVDKLASED-EKEKYNRYFLR 214

  Fly   231 DYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCA 295
            .|::.:.::::||.|.|...:.....|....:...|...||:.|..:.|.|.||..:.||:.|.:
plant   215 SYIEDNRKMKWCPAPGCDFAIDFVAGSGNYDVSCLCSFSFCWNCTEEAHRPVDCSTVSKWILKNS 279

  Fly   296 DDSETANYISAHTKDCPKCHICIEKNGGCNHMQCF-NCKHDFCWMCLGDWKTHGSE---YYECSR 356
            .:||..|:|.|::|.||:|...||||.||.||.|. .||::|||:|||.|..||..   :|.|:|
plant   280 AESENMNWILANSKPCPRCKRPIEKNQGCMHMTCTPPCKYEFCWLCLGAWMDHGERTGGFYACNR 344

  Fly   357 Y----KDNPNIANESVHVQAREALKKYLHYYERWENHSKSLK-----LEQQTIDRLRQRINSKVM 412
            |    ::......|.....|:.:|::|.||||||.::..|.:     |:|..:..| ::::.|..
plant   345 YEVAKQEGQYDETERRREMAKNSLERYTHYYERWASNQTSRQKAMADLQQAQMQNL-EKLSDKQC 408

  Fly   413 NGSGTWIDWQYLFNAAALLAKCRYTLQYTYPYAYYM--EAGSRKNLFEYQQAQLEAEIENLSWKI 475
            ....   ..:::..|...:.:||..|::||.|.||:  ...:::..|||.|.:.|:.:|.|...:
plant   409 TPES---QLKFILEAWLQIIECRRVLKWTYAYGYYLPEHEHAKRQFFEYLQGEAESGLERLHQCV 470

  Fly   476 ER-------AE--TTDLGDLENQMDIAEKRRTTLLKDFF 505
            |:       ||  :.|..|...::    ...|::.|::|
plant   471 EKDLVQFLIAEGPSKDFNDFRTKL----AGLTSVTKNYF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	19/53 (36%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	14/61 (23%)
ARI7	NP_180709.3	RING-HC_RBR_TRIAD1_like	137..187	CDD:319537	18/49 (37%)
		IBR	206..268	CDD:214763	14/61 (23%)
		IBR	<290..329	CDD:396187	22/38 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		mtm1045
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890