DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and Cul9

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_011245024.1	Gene:	Cul9 / 78309	MGIID:	1925559	Length:	2580	Species:	Mus musculus

Alignment Length:	448	Identity:	112/448 - (25%)
Similarity:	175/448 - (39%)	Gaps:	73/448 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKPPSVA 114
            ::.:::|.|:.:.|.::...|.:.|.:|:.||....|....:::.|..|...||:.|.::.|...
Mouse  2043 MSPQEVEGLMEQTVRQVQETLNLEPDVAQHLLAHSHWGTEQLLQSYSDDPEPLLLAAGLRVPQAQ 2107

  Fly   115 VTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLG--DKFYSLACGHSFCKD 177
            |..|                              |...||||. :.||  |...||.|.|..||.
Mouse  2108 VVPT------------------------------RPDQCPVCV-TPLGPHDDSPSLCCLHCCCKS 2141

  Fly   178 CWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFC 242
            ||..|..|:|.|.......|....|..:.....:..:|:.|.:..||::...:.||:|...|.:|
Mouse  2142 CWNEYLTTRIEQNFVLNCTCPIADCPAQPTGAFIRNIVSSPEVISKYEKALLRGYVESCSNLTWC 2206

  Fly   243 PGP-NCQIIVQSSEISAKRAICKACHTGFCFRCGM-DYHAPTDCQVIKKWLTKCADD-------- 297
            ..| .|..|:....:.: ...|..|....||.|.. :.|.|..|..:.:|:    ||
Mouse  2207 TNPQGCDRILCRQGLGS-GTTCSKCGWASCFSCSFPEAHYPASCGHMSQWV----DDGGYYDGMS 2266

  Fly   298 --SETANYISAHTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWMCLGDWKTHGSEYYECSRYKDN 360
              :::.:.....:|.||.|...||||.||.||.|..|.|.|||.||..||....:||.||..:|.
Mouse  2267 VEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCARCNHGFCWRCLKSWKPSHKDYYNCSAMEDC 2331

  Fly   361 PNIANESVHVQAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINS-------KVMNGSGTW 418
            ..:..|......|....:.:|.:       .|:.|.|:....||.:.::       |
Mouse  2332 MKVLGEVERGLLRSPAYQNVHSH-------LSMCLHQEFAVNLRNQASAIQEVPPPK-------- 2381

  Fly   419 IDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIE 476
             .:.:|.:|...|.:.|..|.|...|::|.:.....::.|.|...||.....|...:|
Mouse  2382 -SFTFLQDACRALEQARKVLAYACVYSFYSQDTEYMDVVEQQTENLELHTNALQILLE 2438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	21/54 (39%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	17/63 (27%)
Cul9	XP_011245024.1	Cul7	382..456	CDD:371573
		APC10-like	1184..1314	CDD:382862
		COG5647	<1736..1989	CDD:227934
		Cullin	<1740..1856	CDD:366357
		RING_Ubox	2115..2166	CDD:388418	20/51 (39%)
		RING-HC finger (C3HC4-type)	2116..2166	CDD:319361	20/50 (40%)
		IBR	2187..2249	CDD:214763	17/62 (27%)
		IBR	<2280..2315	CDD:366672	20/34 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920