DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ari-2 and Rnf19b

DIOPT Version :9

Sequence 1:NP_477374.1 Gene:ari-2 / 37542 FlyBaseID:FBgn0025186 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_001355692.1 Gene:Rnf19b / 75234 MGIID:1922484 Length:732 Species:Mus musculus


Alignment Length:266 Identity:71/266 - (26%)
Similarity:113/266 - (42%) Gaps:50/266 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 PPSVAVTDT------ASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVC-------ASSQL 161
            ||:.|..:.      |..|..||.|:...:.:...:..|:.........||:|       .:.:|
Mouse    67 PPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRL 131

  Fly   162 GDKFYSLACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRV-PEDLVLTLVTRPVMRDKYQ 225
                  |:|.|..|:||...|...:|.:. ...|.|  ..|:.|: |.|:.|.|...|:|. ||:
Mouse   132 ------LSCPHRSCRDCLRHYLRLEISES-RVPISC--PECSERLNPHDIRLLLADPPLMH-KYE 186

  Fly   226 QFAFKDYVKSHPELRFCPGPNC-QIIVQSSEISAKRAIC--KACHTGFCFRCGMDYHAPTDCQVI 287
            :|..:.|:.|.|:.|:||.|:| ..::.....|..:..|  :.|.|.||:.|...:|....|.:.
Mouse   187 EFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMA 251

  Fly   288 KKWLTKCADDSETANYISAHT---------------KDCPKCHICIEK--NGGCNHMQCFNCKHD 335
            ::      ..::|....:.||               |.||:|...|.|  :|.||||.|..|..:
Mouse   252 RQ------QRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCE 310

  Fly   336 FCWMCL 341
            |||:|:
Mouse   311 FCWLCM 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ari-2NP_477374.1 RING-HC_RBR_TRIAD1 151..204 CDD:319687 15/59 (25%)
IBR 222..284 CDD:214763 19/64 (30%)
Rnf19bNP_001355692.1 Required for ubiquitin ligase activity and for protection against staurosporin-induced cell death. /evidence=ECO:0000250|UniProtKB:Q6ZMZ0 1..315 70/263 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..109 9/41 (22%)
TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221 112..334 62/221 (28%)
RING-HC_RBR_RNF19B 116..169 CDD:319690 16/61 (26%)
RING-HC finger (C3HC4-type) 116..163 CDD:319690 14/55 (25%)
IBR 184..248 CDD:214763 19/63 (30%)
IBR <280..318 CDD:307574 17/37 (46%)
AzlC <344..433 CDD:351157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..644
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..732
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.