DRSC/TRiP Functional Genomics Resources

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Protein Alignment ari-2 and RNF31

DIOPT Version :9

Sequence 1:NP_477374.1 Gene:ari-2 / 37542 FlyBaseID:FBgn0025186 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_060469.4 Gene:RNF31 / 55072 HGNCID:16031 Length:1072 Species:Homo sapiens


Alignment Length:551 Identity:111/551 - (20%)
Similarity:175/551 - (31%) Gaps:163/551 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DNDGEYDDDYDYYNTGEDC------DVERLDPKRADPEYFEYECLTVE--DIEKLLNE----RVE 64
            |..|..|:      ..|:|      .|:.|......||....:.|...  |:.:.|.|    |:|
Human   560 DRHGNLDE------AVEECVRTRRRKVQELQSLGFGPEEGSLQALFQHGGDVSRALTELQRQRLE 618

  Fly    65 KLNTIL-----QITP--------SLAKVLLLEH---QWNNVAVVEKYRQDANALLVTARIKPPSV 113
            .....|     :.||        ||.:.||..:   .|....:.....|:.          |.:.
Human   619 PFRQRLWDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAELALSLLQET----------PRNY 673

  Fly   114 AVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSL-ACGHSFCKD 177
            .:.|.......:.....||              :..:|.|.||..:...::..:| :|..:.|.|
Human   674 ELGDVVEAVRHSQDRAFLR--------------RLLAQECAVCGWALPHNRMQALTSCECTICPD 724

  Fly   178 CWTIYFETQIFQGISTQIGCMA----------QMCNVRVPEDLVLTLVTRPVMRDKYQQFAFK-- 230
            |:..:|...:.:...|.:.|.|          |:.:.....|:.|.....|   |.|..|..|  
Human   725 CFRQHFTIALKEKHITDMVCPACGRPDLTDDTQLLSYFSTLDIQLRESLEP---DAYALFHKKLT 786

  Fly   231 -DYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDY---HAPTDCQVIKKWL 291
             ..:...|:..:|...:...|.:..::   .|.|..||..||.||...:   |....|:..:.| 
Human   787 EGVLMRDPKFLWCAQCSFGFIYEREQL---EATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNW- 847

  Fly   292 TKCADDSE-----TANYISAHTKDCPKCHICIE-KNGGCNHMQCFNCKHDFCWMCLGDWKTHGSE 350
             |..:|.|     .|.|:..:..|||||..... ..|||.|..|..|:|.||..|.       :.
Human   848 -KRMNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCY-------NA 904

  Fly   351 YYECSRYKDNPNIANESVHVQAREALKKYLH---------YYERWENHSKSLKLEQQTID----- 401
            :|..::..: ||.           .:||.||         |...|    .:|:|::...|     
Human   905 FYAKNKCPE-PNC-----------RVKKSLHGHHPRDCLFYLRDW----TALRLQKLLQDNNVMF 953

  Fly   402 RLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRK-----------N 455
            .......::.:.|.|                 ||...|...|.....||..::           :
Human   954 NTEPPAGARAVPGGG-----------------CRVIEQKEVPNGLRDEACGKETPAGYAGLCQAH 1001

  Fly   456 LFEYQQAQLEA---------EIENLSWKIER 477
            ..||..:.:.|         |:|.|....||
Human  1002 YKEYLVSLINAHSLDPATLYEVEELETATER 1032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ari-2NP_477374.1 RING-HC_RBR_TRIAD1 151..204 CDD:319687 14/63 (22%)
IBR 222..284 CDD:214763 16/67 (24%)
RNF31NP_060469.4 Polyubiquitin-binding 1..485
PUB_RNF31 52..153 CDD:198422
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 263..290
RanBP2-type Zn finger 304..323 CDD:275376
RanBP2-type Zn finger 354..373 CDD:275376
RanBP2-type Zn finger 413..432 CDD:275376
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..484
HOIP-UBA 483..627 CDD:293283 16/72 (22%)
Interaction with RBCK1 563..616 12/58 (21%)
UBA_RNF31 571..625 CDD:270510 11/53 (21%)
TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221 695..929 62/260 (24%)
NMD3 699..>749 CDD:282790 12/49 (24%)
IBR 779..841 CDD:214763 14/64 (22%)
LDD domain 910..1072 27/156 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1812
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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