Protein Alignment ari-2 and RNF216

DIOPT Version :9

• Sequence 1: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_996994.1
• Gene: RNF216 / 54476
• HGNCID: 21698
• Length: 923
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 85/435 - (19%)
• Similarity: 156/435 - (35%)
• Gaps: 108/435 - (24%)

  Fly    19 DDYDYYN---TGEDCDVERLDPKRADPEYFEYECLTVEDIE--------------KLLNERVEKL 66
            |.:||..   ..:.|.::..|...||     ::.|:.:||:              |.|::.::|.
Human   413 DFFDYSKLTPLDQRCFIQAADLLMAD-----FKVLSSQDIKWALHELKGHYAITRKALSDAIKKW 472

  Fly    67 NTILQITPSLAKVLLLEHQWNNVAVVE-KYRQ----------------------DANALLVTARI 108
            .   :::|..:.......|.|..:.:: |:.|                      |..|||
Human   473 Q---ELSPETSGKRKKRKQMNQYSYIDFKFEQGDIKIEKRMFFLENKRRHCRSYDRRALL----- 529

  Fly   109 KPPSVAVTDTASTSAAAASAQ------LLRLGSSGYKTTASATPQYRSQM--CPVCASSQLGDKF 165
              |:|..............|:      .|::....|        |...|:  |..|......::.
Human   530 --PAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQY--------QKDGQLIECRCCYGEFPFEEL 584

  Fly   166 YSLACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFK 230
            ...|..|.|||:|...|.:..:|.....::.||...|....|...:..::.:.::...|::.|.:
Human   585 TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEE 649

  Fly   231 DYVKSH-PELRFCPGPNCQIIVQSSEISAKRAIC--KACHTGFCFRC-GM-DYHAPTDCQVIKKW 290
            :...:: .||..||..:...::.|   ..||..|  ..|....|.:| |: ..|....|:.:.:
Human   650 EVAAAYADELVRCPSCSFPALLDS---DVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAE- 710

  Fly   291 LTKCADDSETANYI-----SAHTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWMC---LGDW--- 344
                .||.:....|     :|..:.|.||...:.|:.|||.|.| .|....|::|   :..:
Human   711 ----KDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSC-RCGAQMCYLCRVSINGYDHF 770

  Fly   345 ----KTHGSEYYECSR-------YKDNPNIANESVHVQAREALKK 378
                ::.|:...||||       .:|:..:. |.:..:|.|..|:
Human   771 CQHPRSPGAPCQECSRCSLWTDPTEDDEKLI-EEIQKEAEEEQKR 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	14/54 (26%)
		IBR	222..284	CDD:214763	15/66 (23%)
RNF216	NP_996994.1	RING-HC_RBR_RNF216	570..626	CDD:319544	13/55 (24%)
		RING-HC finger (C3HC4-type)	572..621	CDD:319544	12/48 (25%)
		IBR	712..762	CDD:307574	16/50 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810