Protein Alignment ari-2 and RNF216

DIOPT Version :10

• Sequence 1: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_996994.1
• Gene: RNF216 / 54476
• HGNCID: 21698
• Length: 923
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 85/435 - (19%)
• Similarity: 156/435 - (35%)
• Gaps: 108/435 - (24%)

  Fly    19 DDYDYYN---TGEDCDVERLDPKRADPEYFEYECLTVEDIE--------------KLLNERVEKL 66
            |.:||..   ..:.|.::..|...||     ::.|:.:||:              |.|::.::|.
Human   413 DFFDYSKLTPLDQRCFIQAADLLMAD-----FKVLSSQDIKWALHELKGHYAITRKALSDAIKKW 472

  Fly    67 NTILQITPSLAKVLLLEHQWNNVAVVE-KYRQ----------------------DANALLVTARI 108
            .   :::|..:.......|.|..:.:: |:.|                      |..|||
Human   473 Q---ELSPETSGKRKKRKQMNQYSYIDFKFEQGDIKIEKRMFFLENKRRHCRSYDRRALL----- 529

  Fly   109 KPPSVAVTDTASTSAAAASAQ------LLRLGSSGYKTTASATPQYRSQM--CPVCASSQLGDKF 165
              |:|..............|:      .|::....|        |...|:  |..|......::.
Human   530 --PAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQY--------QKDGQLIECRCCYGEFPFEEL 584

  Fly   166 YSLACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFK 230
            ...|..|.|||:|...|.:..:|.....::.||...|....|...:..::.:.::...|::.|.:
Human   585 TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEE 649

  Fly   231 DYVKSH-PELRFCPGPNCQIIVQSSEISAKRAIC--KACHTGFCFRC-GM-DYHAPTDCQVIKKW 290
            :...:: .||..||..:...::.|   ..||..|  ..|....|.:| |: ..|....|:.:.:
Human   650 EVAAAYADELVRCPSCSFPALLDS---DVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAE- 710

  Fly   291 LTKCADDSETANYI-----SAHTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWMC---LGDW--- 344
                .||.:....|     :|..:.|.||...:.|:.|||.|.| .|....|::|   :..:
Human   711 ----KDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSC-RCGAQMCYLCRVSINGYDHF 770

  Fly   345 ----KTHGSEYYECSR-------YKDNPNIANESVHVQAREALKK 378
                ::.|:...||||       .:|:..:. |.:..:|.|..|:
Human   771 CQHPRSPGAPCQECSRCSLWTDPTEDDEKLI-EEIQKEAEEEQKR 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	152..204	CDD:438429	13/53 (25%)
		BRcat_RBR_TRIAD1	231..302	CDD:439005	16/75 (21%)
		Rcat_RBR_TRIAD1	306..361	CDD:439021	19/71 (27%)
		Ariadne	371..>477	CDD:466073	3/8 (38%)
RNF216	NP_996994.1	RING-HC_RBR_RNF216	570..626	CDD:438292	13/55 (24%)
		BRcat_RBR_RNF216	659..710	CDD:439000	13/53 (25%)
		Rcat_RBR_RNF216	721..777	CDD:439014	13/56 (23%)