DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-2 and Rnf31

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001102338.2	Gene:	Rnf31 / 364386	RGDID:	1305513	Length:	1062	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	93/432 - (21%)
Similarity:	145/432 - (33%)	Gaps:	123/432 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DPEYFEYECL---------------TVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNV- 89
            |||...:.|.               .||:..:....:|::|.: |...|....:..|.....:|
  Rat   533 DPELGAFSCQEARKAWLDRHGNLDEAVEECVRARRRKVQELQS-LGFEPKEGSLQALFQHGGDVA 596

  Fly    90 -AVVEKYRQDANALLVTARIKP-----------PS---------------VAVTDTASTSAAAAS 127
             |:.|..||         |::|           |:               :||....|...|..:
  Rat   597 RALTELQRQ---------RLEPFHQRLWGRDPEPTPCWDGLDRQSLVRRLLAVYTLPSWGRAELA 652

  Fly   128 AQLLRLGSSGYK----TTASATPQYR-------SQMCPVCASSQLGDKFYSL-ACGHSFCKDCWT 180
            ..||:.....|:    ..|....|.|       :|.|.||..:...::..:| :|..:.|.:|:.
  Rat   653 LALLQETPRNYELLDVVEAVRHSQDRAFLRRLLAQECAVCGWALPRNRMQALISCECTICPECFR 717

  Fly   181 IYFETQIFQGISTQIGCM----------AQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFK---DY 232
            .:|...:.:...|.:.|.          ||:.:.....|:.|.....|   |.|..|..|   ..
  Rat   718 QHFTIALKEKHITDMVCPACGRPDLTDDAQLLSYFSTLDIQLRESLEP---DAYALFHKKLTEAV 779

  Fly   233 VKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDY---HAPTDCQVIKKWLTKC 294
            :...|:..:|...:...|.:..::   .|.|..||..||.||...:   |....|:..:.|  |.
  Rat   780 LMRDPKFLWCAQCSFGFIYEREQL---EATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNW--KR 839

  Fly   295 ADDSE-----TANYISAHTKDCPKCHICIE-KNGGCNHMQCFNCKHDFCWMCLGDWKTHGSEYYE 353
            .:|.|     .|.|:..:..|||||..... ..|||.|..|..|:|.||..|.       :.:|.
  Rat   840 TNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCY-------NAFYA 897

  Fly   354 CSRYKDNPNIANESVHVQAREALKKYLH---------YYERW 386
            .::..| ||.           .:||.||         |...|
  Rat   898 KNKCPD-PNC-----------KVKKSLHGHHPRDCLFYLRDW 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	13/63 (21%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	16/67 (24%)
Rnf31	NP_001102338.2	PUB	51..152	CDD:301591
		RanBP2-type Zn finger	300..319	CDD:275376
		RanBP2-type Zn finger	348..367	CDD:275376
		RanBP2-type Zn finger	407..426	CDD:275376
		HOIP-UBA	473..617	CDD:293283	18/93 (19%)
		PdxA	<523..>594	CDD:294567	11/61 (18%)
		UBA_RNF31	561..615	CDD:270510	12/63 (19%)
		NMD3	689..>739	CDD:282790	10/49 (20%)
		IBR	769..831	CDD:214763	14/64 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810