DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and LUBEL

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	96/451 - (21%)
Similarity:	142/451 - (31%)	Gaps:	179/451 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWN---NVAVV----EKYRQDANALLVTARI 108
            ||..|.|..||...|.|:    ||...||.|....::   .::.|    |.|.|..::.:.|:|:
  Fly  2288 TVSKIPKPTNEPTNKSNS----TPLNKKVPLRSKSFSAPMGISSVKRIQEVYLQKQSSSIATSRV 2348

  Fly   109 KPPSVAVT----------------DTASTS--AAAASAQLLR----------------LGSSGYK 139
            ...|..||                |..|||  ||||:|.||:                .....|:
  Fly  2349 PLKSSPVTKKSINDAISRFNSNQADGPSTSGAAAAAAAALLKPRSQPRIPKKKYHETCFSDDDYE 2413

  Fly   140 TTAS---------ATPQYRSQM------------------------------------------- 152
            |:|:         |.||...|:
  Fly  2414 TSATEEEQEEPNLAEPQKAEQLKRKMSMPVFRAYPSVQEPVIEDPAILARKYVDQELVTNIAEAQ 2478

  Fly   153 -----------------------------------CPVCASSQLGDKFYS-LACGHSFCKDCWTI 181
                                               |.:|.:|...::..| |.|.|..||.|...
  Fly  2479 IAATLVSMKFSEDVALWAARECSDLDQAIAMLQQECELCMNSYPMNQMVSMLKCLHKCCKQCAKS 2543

  Fly   182 YFETQIF-QGISTQIGCMAQMCNVRVPE------------------DLVLTLVTRPVMRDKYQQF 227
            ||..||. :.|:   .|....|  ::||                  |:.|..:....:.:.:|:.
  Fly  2544 YFTVQITDRSIN---DCSCPFC--KLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRK 2603

  Fly   228 AFKDYVKSHPELRFCPGPNCQIIVQSSEISA----KRAICKACHTGFCFRCGMDY---HAPTDCQ 285
            .....:...|..::|       |..||...|    ||.||..|.:..|.:|...:   |..:.|:
  Fly  2604 LRDRSLLQDPNFKWC-------IQCSSGFFARPKQKRLICPDCGSVTCAQCRKPWERQHEGSSCE 2661

  Fly   286 VIKKWLTKCADDSE-----TANYISAHTKDCPKCHICIE-KNGGCNHMQCFNCKHDFCWMC 340
            ...:|  |..:|.|     ...:::.:..|||||..... ..|||.|..|..||.:||:.|
  Fly  2662 AYLEW--KRENDPELQAQGVQEHLAQNGIDCPKCKFRYSLARGGCMHFTCTQCKFEFCYGC 2720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	18/132 (14%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	15/68 (22%)
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384	8/22 (36%)
		RING-HC_RNF169	2513..2563	CDD:319465	17/54 (31%)
		IBR	2598..2660	CDD:214763	15/68 (22%)
		IBR	<2690..2724	CDD:396187	14/31 (45%)
		E3_UbLigase_RBR	2760..2858	CDD:407926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810