Protein Alignment ari-2 and arih1

DIOPT Version :10

• Sequence 1: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_956052.1
• Gene: arih1 / 327005
• ZFINID: ZDB-GENE-030131-5213
• Length: 527
• Species: Danio rerio
• Alignment Length: 540
• Identity: 179/540 - (33%)
• Similarity: 284/540 - (52%)
• Gaps: 67/540 - (12%)

  Fly     1 MDSD----IEMDME----SDNDGEYDDDYDYYNTGEDCDVERLDPKRA----------------- 40
            ||||    .|.|.|    |::.||.:...|....||   ||.:||..|
Zfish     1 MDSDEGYNYEFDDEEEECSEDSGEEETADDTLELGE---VELVDPVVAGGERDDCGETGGSGLGP 62

  Fly    41 --DPEYFEYECLTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALL 103
              |.|.:.:|.||.|.|.:.:.|.:.::|.::|...::.::||....|:...::|:| .|.|...
Zfish    63 GQDEEDYRFEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERY-FDGNLDK 126

  Fly   104 VTAR---IKPPSVAVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKF 165
            :.:.   |.|...:.|...:|.::|                       :...|.:|..:.....|
Zfish   127 LFSECHVINPSKKSRTRLMNTRSSA-----------------------QDMPCQICYLNYPNSYF 168

  Fly   166 YSLACGHSFCKDCWTIYFETQIF-QGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAF 229
            ..|.|||.||..||..|..|:|. :|:...|.|.|..|::.|.::.|:.|:|...::.|||....
Zfish   169 TGLECGHKFCMQCWGDYLTTKIIEEGMGQTISCPAHSCDILVDDNTVMRLITDSKVKLKYQHLIT 233

  Fly   230 KDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKC 294
            ..:|:.:..|::||.|:|..:|:.....||...|| |...|||.||.::|.|..|:.::||:.||
Zfish   234 NSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCK-CGRQFCFNCGENWHDPVKCKWLRKWIKKC 297

  Fly   295 ADDSETANYISAHTKDCPKCHICIEKNGGCNHMQC--FNCKHDFCWMCLGDWKTHGSEYYECSRY 357
            .|||||:|:|:|:||:|||||:.|||:||||||.|  .|||.:|||:|||.|:.|||.:|.|:||
Zfish   298 DDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRY 362

  Fly   358 KDNPNIANESVHVQAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQ 422
            .::...|......::|.||::||.|..|:.||.:||:.|.:...:::|:: .::...:.:||:.|
Zfish   363 NEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKM-EEMQQHNMSWIEVQ 426

  Fly   423 YLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERAETTD-LGDL 486
            :|..|..:|.:||.||.:||.:|:|::..::..:||..||.||...|.||..:||..:.| |.|:
Zfish   427 FLKKAVDVLCQCRSTLMFTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDI 491

  Fly   487 ENQMD----IAEKRRTTLLK 502
            :.::.    ..|.||..||:
Zfish   492 KQKVQDKYRYCESRRRVLLQ 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	152..204	CDD:438429	19/52 (37%)
		BRcat_RBR_TRIAD1	231..302	CDD:439005	29/70 (41%)
		Rcat_RBR_TRIAD1	306..361	CDD:439021	35/56 (63%)
		Ariadne	371..>477	CDD:466073	36/105 (34%)
arih1	NP_956052.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..66		18/67 (27%)
		UBA-like. /evidence=ECO:0000250|UniProtKB:Q9Y4X5	75..123		12/48 (25%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	152..363		91/211 (43%)
		RING-HC_RBR_HHARI	154..212	CDD:438288	20/57 (35%)
		BRcat_RBR_HHARI-like	221..302	CDD:439004	29/81 (36%)
		Rcat_RBR_HHARI-like	306..363	CDD:439017	35/56 (63%)
		Ariadne	364..>495	CDD:466073	42/131 (32%)
		Ariadne domain. /evidence=ECO:0000250|UniProtKB:Q9Y4X5	378..527		46/135 (34%)