DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-2 and Arih2

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001012275.1	Gene:	Arih2 / 316005	RGDID:	1305839	Length:	492	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	274/506 - (54%)
Similarity:	345/506 - (68%)	Gaps:	33/506 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSDIEMDMESDNDGEYD--DDYDYYNTGEDCDVERLDPKRADPEYFEYECLTVEDIEKLLNERVE 64
            :.|.:.:.|.:.:.|.|  |..||| .|...|||:......|||.:::.|||.::.|..|:|.:.
  Rat    14 EEDYDPNCEEEEEEEEDPGDIEDYY-VGVASDVEQQGADAFDPEEYQFTCLTYKESEGALHEHMT 77

  Fly    65 KLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKP-PSVAVTDTASTSAAAASA 128
            .|.:.|:::.|:||::|:...|....::::||.::..|||.||::| ||
  Rat    78 SLASALKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPS---------------- 126

  Fly   129 QLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQGIST 193
                      |...:|.|.:.   |.||......:...||.|.|.||:.||..:....:..|:..
  Rat   127 ----------KHVPTAHPPHH---CAVCMQFVRKENLLSLTCQHQFCRSCWEQHCSVLVKDGVGV 178

  Fly   194 QIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISA 258
            .|.||||.|.:|.|||.|..|:....:||||:::.|:|||:||.:|:.|||.:|.::::..|..|
  Rat   179 GISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRA 243

  Fly   259 KRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGG 323
            :|..|..|:..|||:|...|||||||..|:||||||||||||||||||||||||||:||||||||
  Rat   244 RRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGG 308

  Fly   324 CNHMQCFNCKHDFCWMCLGDWKTHGSEYYECSRYKDNPNIANESVHVQAREALKKYLHYYERWEN 388
            ||||||..|||||||||||||||||||||||||||:||:|.|:|...||||||||||.|:|||||
  Rat   309 CNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWEN 373

  Fly   389 HSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSR 453
            |:|||:||.||..|:.::|..:|||..|||||||||.|||.||||||||||||||||||||:|.|
  Rat   374 HNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPR 438

  Fly   454 KNLFEYQQAQLEAEIENLSWKIERAETTDLGDLENQMDIAEKRRTTLLKDF 504
            |.|||||||||||||||||||:|||::.|.|||||||.|||:||.||||||
  Rat   439 KKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDF 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	18/52 (35%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	28/61 (46%)
Arih2	NP_001012275.1	RING-HC_RBR_TRIAD1	136..189	CDD:319687	18/55 (33%)
		IBR	207..269	CDD:214763	28/61 (46%)
		IBR	<297..329	CDD:396187	28/31 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344980
Domainoid	1	1.000	259	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48424
Inparanoid	1	1.050	574	1.000	Inparanoid score	I1011
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		oto97200
orthoMCL	1	0.900	-	-		OOG6_107754
Panther	1	1.100	-	-	LDO	PTHR11685
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X447
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770