DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-2 and RNF19A

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001267468.1	Gene:	RNF19A / 25897	HGNCID:	13432	Length:	838	Species:	Homo sapiens

Alignment Length:	215	Identity:	56/215 - (26%)
Similarity:	93/215 - (43%)	Gaps:	39/215 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 CPVCASSQLGDKFYS-LACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRV-PEDLVLTLV 215
            ||:|......|:|.. :.|.|..|.||...|...:|.:   :::......|..|. |.|:.| ::
Human   132 CPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISE---SRVNISCPECTERFNPHDIRL-IL 192

  Fly   216 TRPVMRDKYQQFAFKDYVKSHPELRFCPGPNC-QIIVQSSEISAKRAIC--KACHTGFCFRCGMD 277
            :..|:.:||::|..:.::.:.|:.|:||.|:| ..::.....|..:..|  :.|.|.||:.|...
Human   193 SDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTCGREGCGTEFCYHCKQI 257

  Fly   278 YHAPTDCQVIKKWLTKCADDSETANYISAHT-------------------KDCPKCHICIEK--N 321
            :|....|...::         |.|..:...|                   |.||:|...|.|  :
Human   258 WHPNQTCDAARQ---------ERAQSLRLRTIRSSSISYSQESGAAADDIKPCPRCAAYIIKMND 313

  Fly   322 GGCNHMQCFNCKHDFCWMCL 341
            |.||||.|..|..:|||:|:
Human   314 GSCNHMTCAVCGCEFCWLCM 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	13/51 (25%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	17/64 (27%)
RNF19A	NP_001267468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..61
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	128..351		56/215 (26%)
		RING-HC_RBR_RNF19A	131..185	CDD:319689	14/55 (25%)
		RING-HC finger (C3HC4-type)	132..179	CDD:319689	12/49 (24%)
		IBR	199..264	CDD:214763	17/64 (27%)
		IBR	<297..335	CDD:307574	17/37 (46%)
		AzlC	<361..450	CDD:321048
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..685
		Interaction with CASR. /evidence=ECO:0000269\|PubMed:16513638	660..838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910