Protein Alignment ari-2 and ARIH1

DIOPT Version :10

• Sequence 1: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_005735.2
• Gene: ARIH1 / 25820
• HGNCID: 689
• Length: 557
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 179/567 - (31%)
• Similarity: 284/567 - (50%)
• Gaps: 91/567 - (16%)

  Fly     1 MDSD----IEMD-----MESDNDGEYDDDYDYYNTGEDC----DVERLD---------------- 36
            ||||    .|.|     .|.|:..|.::|.|.....:|.    :||.::
Human     1 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDGLLCGE 65

  Fly    37 -------------------------PKRADPEYFEYECLTVEDIEKLLNERVEKLNTILQITPSL 76
                                     |.....|.:.||.||.|.|.:.:.|.:.::|.::|...::
Human    66 TGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATI 130

  Fly    77 AKVLLLEHQWNNVAVVEKYRQDANALLVTAR---IKPPSVAVTDTASTSAAAASAQLLRLGSSGY 138
            .::||....|:...::|:| .|.|...:.|.   |.|...:.|...:|.::|
Human   131 TRILLSHFNWDKEKLMERY-FDGNLEKLFAECHVINPSKKSRTRQMNTRSSA------------- 181

  Fly   139 KTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIF-QGISTQIGCMAQMC 202
                      :...|.:|..:.....|..|.|||.||..||:.|..|:|. :|:...|.|.|..|
Human   182 ----------QDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGC 236

  Fly   203 NVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACH 267
            ::.|.::.|:.|:|...::.|||......:|:.:..|::||.|:|..:|:.....||...|| |.
Human   237 DILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCK-CG 300

  Fly   268 TGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNHMQC--F 330
            ..|||.||.::|.|..|:.:|||:.||.|||||:|:|:|:||:|||||:.|||:||||||.|  .
Human   301 RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQ 365

  Fly   331 NCKHDFCWMCLGDWKTHGSEYYECSRYKDNPNIANESVHVQAREALKKYLHYYERWENHSKSLKL 395
            |||.:|||:|||.|:.|||.:|.|:||.::...|......::|.||::||.|..|:.||.:||:.
Human   366 NCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRF 430

  Fly   396 EQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQ 460
            |.:...:::|:: .::...:.:||:.|:|..|..:|.:||.||.|||.:|:|::..::..:||..
Human   431 EHKLYAQVKQKM-EEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENN 494

  Fly   461 QAQLEAEIENLSWKIERAETTD-LGDLENQMD----IAEKRRTTLLK 502
            ||.||...|.||..:||..:.| |.|::.::.    ..|.||..||:
Human   495 QADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQ 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	152..204	CDD:438429	19/52 (37%)
		BRcat_RBR_TRIAD1	231..302	CDD:439005	30/70 (43%)
		Rcat_RBR_TRIAD1	306..361	CDD:439021	35/56 (63%)
		Ariadne	371..>477	CDD:466073	37/105 (35%)
ARIH1	NP_005735.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..95		15/93 (16%)
		UBA-like. /evidence=ECO:0000305|PubMed:23707686	105..153		12/48 (25%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	182..393		92/211 (44%)
		RING-HC_RBR_HHARI	184..242	CDD:438288	20/57 (35%)
		BRcat_RBR_HHARI-like	251..332	CDD:439004	30/81 (37%)
		Rcat_RBR_HHARI-like	336..393	CDD:439017	35/56 (63%)
		Ariadne	394..>525	CDD:466073	43/131 (33%)
		Ariadne domain. /evidence=ECO:0000305|PubMed:23707686	408..557		47/135 (35%)