DRSC/TRiP Functional Genomics Resources

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Protein Alignment ari-2 and ARIH1

DIOPT Version :9

Sequence 1:NP_477374.1 Gene:ari-2 / 37542 FlyBaseID:FBgn0025186 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_005735.2 Gene:ARIH1 / 25820 HGNCID:689 Length:557 Species:Homo sapiens


Alignment Length:567 Identity:179/567 - (31%)
Similarity:284/567 - (50%) Gaps:91/567 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDSD----IEMD-----MESDNDGEYDDDYDYYNTGEDC----DVERLD---------------- 36
            ||||    .|.|     .|.|:..|.::|.|.....:|.    :||.::                
Human     1 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDGLLCGE 65

  Fly    37 -------------------------PKRADPEYFEYECLTVEDIEKLLNERVEKLNTILQITPSL 76
                                     |.....|.:.||.||.|.|.:.:.|.:.::|.::|...::
Human    66 TGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATI 130

  Fly    77 AKVLLLEHQWNNVAVVEKYRQDANALLVTAR---IKPPSVAVTDTASTSAAAASAQLLRLGSSGY 138
            .::||....|:...::|:| .|.|...:.|.   |.|...:.|...:|.::|             
Human   131 TRILLSHFNWDKEKLMERY-FDGNLEKLFAECHVINPSKKSRTRQMNTRSSA------------- 181

  Fly   139 KTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIF-QGISTQIGCMAQMC 202
                      :...|.:|..:.....|..|.|||.||..||:.|..|:|. :|:...|.|.|..|
Human   182 ----------QDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGC 236

  Fly   203 NVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACH 267
            ::.|.::.|:.|:|...::.|||......:|:.:..|::||.|:|..:|:.....||...|| |.
Human   237 DILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCK-CG 300

  Fly   268 TGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNHMQC--F 330
            ..|||.||.::|.|..|:.:|||:.||.|||||:|:|:|:||:|||||:.|||:||||||.|  .
Human   301 RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQ 365

  Fly   331 NCKHDFCWMCLGDWKTHGSEYYECSRYKDNPNIANESVHVQAREALKKYLHYYERWENHSKSLKL 395
            |||.:|||:|||.|:.|||.:|.|:||.::...|......::|.||::||.|..|:.||.:||:.
Human   366 NCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRF 430

  Fly   396 EQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQ 460
            |.:...:::|:: .::...:.:||:.|:|..|..:|.:||.||.|||.:|:|::..::..:||..
Human   431 EHKLYAQVKQKM-EEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENN 494

  Fly   461 QAQLEAEIENLSWKIERAETTD-LGDLENQMD----IAEKRRTTLLK 502
            ||.||...|.||..:||..:.| |.|::.::.    ..|.||..||:
Human   495 QADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQ 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ari-2NP_477374.1 RING-HC_RBR_TRIAD1 151..204 CDD:319687 19/53 (36%)
IBR 222..284 CDD:214763 22/61 (36%)
ARIH1NP_005735.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..95 15/93 (16%)
UBA-like. /evidence=ECO:0000305|PubMed:23707686 105..153 12/48 (25%)
TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221 182..393 92/211 (44%)
RING-HC_RBR_HHARI 185..242 CDD:319540 20/56 (36%)
IBR 257..317 CDD:214763 22/60 (37%)
IBR <339..379 CDD:396187 27/39 (69%)
Ariadne domain. /evidence=ECO:0000305|PubMed:23707686 408..557 47/135 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54219
OrthoDB 1 1.010 - - D429758at33208
OrthoFinder 1 1.000 - - FOG0000379
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X447
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.930

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