DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-2 and CUL9

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_011512724.1	Gene:	CUL9 / 23113	HGNCID:	15982	Length:	2566	Species:	Homo sapiens

Alignment Length:	441	Identity:	115/441 - (26%)
Similarity:	181/441 - (41%)	Gaps:	67/441 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKPPSVA 114
            ::.:::|.|:.:.|.::...|.:.|.:|:.||....|....:::.|.:|...||:.|
Human  2046 MSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAA-------- 2102

  Fly   115 VTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLG--DKFYSLACGHSFCKD 177
                               |...::  |.|.| .|...||||. |.||  |...||.|.|..||.
Human  2103 -------------------GLCVHQ--AQAVP-VRPDHCPVCV-SPLGCDDDLPSLCCMHYCCKS 2144

  Fly   178 CWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFC 242
            ||..|..|:|.|.:.....|....|..:.....:..:|:.|.:..||::...:.||:|...|.:|
Human  2145 CWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWC 2209

  Fly   243 PGP-NCQIIVQSSEISAKRAICKACHTGFCFRCGM-DYHAPTDCQVIKKWLTKCADD-------- 297
            ..| .|..|:....:.. ...|..|....||.|.. :.|.|..|..:.:|:    ||
Human  2210 TNPQGCDRILCRQGLGC-GTTCSKCGWASCFNCSFPEAHYPASCGHMSQWV----DDGGYYDGMS 2269

  Fly   298 --SETANYISAHTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWMCLGDWKTHGSEYYECSRYKDN 360
              :::.:.....:|.||.|...||||.||.||.|..|.|.|||.||..||.:..:||.||
Human  2270 VEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCS----- 2329

  Fly   361 PNIANESVHVQAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLF 425
                 ..|...||:. |::..|.||...|.::    ::....||.|:::  ::.......:.:|.
Human  2330 -----AMVSKAARQE-KRFQDYNERCTFHHQA----REFAVNLRNRVSA--IHEVPPPRSFTFLN 2382

  Fly   426 NAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIE 476
            :|...|.:.|..|.|...|::|.:.....::.|.|...||.....|...:|
Human  2383 DACQGLEQARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLE 2433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	22/54 (41%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	17/63 (27%)
CUL9	XP_011512724.1	Cul7	366..440	CDD:288381
		UBA2_C	<593..638	CDD:292812
		APC10-like	1167..1297	CDD:295192
		CULLIN	1642..1813	CDD:214545
		Cullin_Nedd8	1913..1993	CDD:299553
		zf-RING_2	2117..2166	CDD:290367	21/49 (43%)
		IBR	2190..2252	CDD:214763	17/62 (27%)
		IBR	<2283..2321	CDD:279784	22/37 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920