Protein Alignment ari-2 and ari-1.1

DIOPT Version :10

• Sequence 1: NP_477374.1
• Gene: ari-2 / 37542
• FlyBaseID: FBgn0025186
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_491749.2
• Gene: ari-1.1 / 172284
• WormBaseID: WBGene00016158
• Length: 494
• Species: Caenorhabditis elegans
• Alignment Length: 531
• Identity: 165/531 - (31%)
• Similarity: 266/531 - (50%)
• Gaps: 87/531 - (16%)

  Fly     2 DSDIEMDMESDNDGEYDD-----------------DYDYYNTGEDCDVERLDPKRADPEYFEYEC 49
            |.:|.||....:.||.||                 ..||.:.||.                :.|.
 Worm     4 DDEINMDDSDSSQGEIDDGCMSDDDGIVLESREQNSSDYKDNGEP----------------DNEV 52

  Fly    50 LTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQ--DANALLVTARIKPPS 112
            |..:.:|..:.:.:..:..:||:...:.::||.:::||..:::|::.:  |....|:.|.:.|
 Worm    53 LNHDSLEAEMKKTITDVQAVLQVKTGVCRILLHKYKWNKESLLERFYEHPDTTTFLIDAHVIP-- 115

  Fly   113 VAVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKD 177
                 .......|..|:                       |.:|.|  ||: ...|:|.|..|..
 Worm   116 -----RRQERLPAGDAE-----------------------CDICCS--LGE-LSGLSCNHRACTQ 149

  Fly   178 CWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFC 242
            ||..|...:|.....::|.|||..|.:.:.::.|:..:|.|.:...|::.....||:::..|::|
 Worm   150 CWKAYLTNKIANNAQSEIECMAPNCKLLIEDEKVMFYITDPTVIATYRKLIVASYVETNRLLKWC 214

  Fly   243 PGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAH 307
            ||.:|...|:.|....:..:| :|.:.|||.||.|:|.|.:|:::|.||.||.|||||:|:|:|:
 Worm   215 PGIDCGKAVRVSHWEPRLVVC-SCGSRFCFSCGHDWHEPVNCRLLKLWLKKCNDDSETSNWINAN 278

  Fly   308 TKDCPKCHICIEKNGGCNHMQCFN--CKHDFCWMCLGDWKTHGSEYYECSRYKDNPNIANESVHV 370
            ||:||||.|.|||:||||||.|.|  |:.:|||||||.|:.|||.:|.|:|:.|:..........
 Worm   279 TKECPKCMITIEKDGGCNHMTCKNTACRFEFCWMCLGPWEPHGSSWYSCNRFDDSAAKNARDAQE 343

  Fly   371 QAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCR 435
            .:|..|::||.||.|:..|.:||:||.:....::.:: .::...|.:||:.|:|..|..:|::||
 Worm   344 VSRANLQRYLFYYNRYMGHQQSLRLEGKLYATVKSKM-EQMQTLSMSWIEVQFLRKAVDVLSECR 407

  Fly   436 YTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERAETTDLGDLENQMDIAEK----- 495
            .||.:||.:|:|::..:...:||..|..||.|.|.||..:||    || |.||.:.:.:|
 Worm   408 RTLMFTYAFAFYLKRDNNAIIFESNQKDLEMETEQLSGFLER----DL-DNENLVTLKQKVQDKY 467

  Fly   496 -----RRTTLL 501
                 ||..||
 Worm   468 RYVEHRRKVLL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	152..204	CDD:438429	18/51 (35%)
		BRcat_RBR_TRIAD1	231..302	CDD:439005	30/70 (43%)
		Rcat_RBR_TRIAD1	306..361	CDD:439021	35/56 (63%)
		Ariadne	371..>477	CDD:466073	36/105 (34%)
ari-1.1	NP_491749.2	RING-HC_RBR_TRIAD1	127..176	CDD:438429	18/74 (24%)
		BRcat_RBR_HHARI-like	189..270	CDD:439004	29/81 (36%)
		Rcat_RBR_HHARI-like	274..331	CDD:439017	35/56 (63%)
		Ariadne	341..>453	CDD:466073	40/117 (34%)