DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ari-2 and cul9

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_021326622.1	Gene:	cul9 / 100332758	-ID:	-	Length:	2587	Species:	Danio rerio

Alignment Length:	455	Identity:	114/455 - (25%)
Similarity:	182/455 - (40%)	Gaps:	79/455 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTA--RIKPPS 112
            :|.|::::|:...|:::...|.:....|:.||:..:||...::::|..|.:||::.|  :|:.|.
Zfish  2052 MTQEEVKQLMQRTVQQVAGTLSLDLDRAEHLLIHCKWNVDLLIQRYTDDPDALVLAAGLKIRNPQ 2116

  Fly   113 VAVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCAS-SQLGDKFYSLACGHSFCK 176
            .|....:.                                ||||.| |:..|....|.|.|..|:
Zfish  2117 PAPGPVSH--------------------------------CPVCLSQSKESDPPPMLCCMHYCCR 2149

  Fly   177 DCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRF 241
            .||..:...:|.|.:.....|....|..:........::|......||.....:.:|:....|.:
Zfish  2150 SCWQEFLTARIEQNLVMNCDCPITDCRAQPTSKFFHNILTDKDTIAKYDSALLRGFVECCSNLTW 2214

  Fly   242 CPGP-NCQIIVQSSEISAKRAICKACHTGFCFRCGM-DYHAPTDCQVIKKWLTKCADD------- 297
            |..| .|..|:....|.: ...|..|....||.|.. :.|.|..|..:.:|:    ||
Zfish  2215 CTNPQGCDQILCKENIGS-MGTCSKCCWSSCFSCNFPEAHYPASCSHMSQWM----DDGGYYEGM 2274

  Fly   298 ---SETANYISAHTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWMCLGDWKTHGSEYYECSRYKD 359
               :::.:.....:|.||.|...||||.||.||.|..|.|.|||.||..||....:||.||
Zfish  2275 SMEAQSKHLAKLISKRCPSCQAQIEKNEGCLHMTCAKCNHGFCWRCLKPWKPTHKDYYNCS---- 2335

  Fly   360 NPNIANESVHVQAREALKKYLHYYERWENHSK----SLKLEQQTIDRLRQRINSKVMNGSGTWID 420
                  ..|...||:. ||:..|.||...|.:    ::.||.:...     ||..:...|.|
Zfish  2336 ------AMVSKAARQE-KKFQDYNERCTFHIQAKDFAINLENKVFS-----INEALQMKSLT--- 2385

  Fly   421 WQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERA--ETTDL 483
              ::.:|..:||:.|..|.|:..|:||.:...:.::.|.|...|:.....|...:|..  :.|||
Zfish  2386 --FVIDACKILAQARKVLAYSCVYSYYNQDTEKMDVMEQQTEALDLHTNALQILLEETLLQCTDL 2448

Fly 484 483
Zfish 2449 2448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	17/53 (32%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	16/63 (25%)
cul9	XP_021326622.1	Cul7	416..490	CDD:314424
		APC10-CUL7	1200..1330	CDD:176486
		Cullin	<1548..1850	CDD:331336
		Cullin_Nedd8	1902..1979	CDD:214883
		RING-HC_RBR_CUL9	2124..2175	CDD:319538	16/82 (20%)
		RING-HC finger (C3HC4-type)	2125..2175	CDD:319538	16/49 (33%)
		IBR	2195..2258	CDD:214763	16/63 (25%)
		IBR	<2289..2324	CDD:307574	20/34 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010