DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ari-2 and cul9

DIOPT Version :9

Sequence 1:	NP_477374.1	Gene:	ari-2 / 37542	FlyBaseID:	FBgn0025186	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001120525.1	Gene:	cul9 / 100145662	XenbaseID:	XB-GENE-877136	Length:	2492	Species:	Xenopus tropicalis

Alignment Length:	450	Identity:	120/450 - (26%)
Similarity:	184/450 - (40%)	Gaps:	67/450 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKPPSVA 114
            |:.||:..|:.:.|.:::..|.|.|..|:.||:..:||...:::||.::...||:
Frog  1964 LSQEDVRALMGQMVAQVSQTLSIDPDTAQHLLIHCKWNVDLLLQKYTEEPELLLI---------- 2018

  Fly   115 VTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASS-QLGDKFYSLACGHSFCKDC 178
                                |||.:......|:.....||||.|. ...:...:|.|.|..||.|
Frog  2019 --------------------SSGLQVRDPQHPESPQPACPVCVSPLSPAEHHPTLCCQHLCCKSC 2063

  Fly   179 WTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCP 243
            |..|..|:|.|.::....|....|..:...|.:..::|...:.:||::...:.:|::...|.:|.
Frog  2064 WKEYLTTRIEQNLALNCTCPTTDCLAQPTSDFISKIITSKEVIEKYEKSLLRGFVENCSNLTWCT 2128

  Fly   244 GPNCQIIVQSSEISAKRAICKACHTGFCFRCGM-DYHAPTDCQVIKKW---------LTKCADDS 298
            .|.....|...|.....|.|..|....||.|.. :.|.|..|..:.:|         :|..|...
Frog  2129 NPQGCDRVLCKEGLGSGAACTKCSWLSCFNCSFPEAHYPASCSHMSQWMDDGGFYEGMTVEAQSK 2193

  Fly   299 ETANYISAHTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWMCLGDWKTHGSEYYECSRYKDNPNI 363
            .....||.|   ||.|...||||.||.||.|..|.|.|||.||..||....:||.||
Frog  2194 HLTKLISKH---CPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKPWKPTHKDYYNCS-------- 2247

  Fly   364 ANESVHVQAREALKKYLHYYER--WENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFN 426
              ..|...||:. |::..|.||  :::.:|...:.      ||:|::  |:..........:|..
Frog  2248 --AMVSKAARQE-KRFQDYNERCTFQHRAKDFAVS------LRKRLS--VLREEPPLRSLTFLIT 2301

  Fly   427 AAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERA--ETTDLG 484
            |..:|.:.|..|.|...|:||.:...|.::.|.|...||..:..|...:|.:  :..|||
Frog  2302 ACRVLEQSRKVLGYACVYSYYNQDSERLDVLESQTENLELHVSALQILLEDSLLQCEDLG 2361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ari-2	NP_477374.1	RING-HC_RBR_TRIAD1	151..204	CDD:319687	18/53 (34%)
ari-2	NP_477374.1	IBR	222..284	CDD:214763	16/62 (26%)
cul9	NP_001120525.1	Cul7	362..436	CDD:288381
		APC10-CUL7	1145..1275	CDD:176486
		Cullin_Nedd8	1827..1904	CDD:214883
		zf-RING_2	2037..2084	CDD:290367	17/46 (37%)
		IBR	2107..2170	CDD:214763	16/62 (26%)
		IBR	<2201..2236	CDD:279784	20/37 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010